Protein Alignment PhKgamma and PHKG2

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_000285.1
• Gene: PHKG2 / 5261
• HGNCID: 8931
• Length: 406
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 213/540 - (39%)
• Similarity: 274/540 - (50%)
• Gaps: 169/540 - (31%)

  Fly     7 DDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHML 71
            :|.|||..|||.||.||:||:::|||:||.||||:.:.||.|||.||:::.|...|.| ....:.
Human     8 EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPE-QLEEVR 71

  Fly    72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQ 136
            ||||:|..|||||.|||:||.|.|.:||.:|:||||:|..|||||||||..|.||||:||:|||.
Human    72 EATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136

  Fly   137 IFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKC 201
            :.|.|.::||.:||||||||||||||:|..::::||||:..|:.||||..|||||||||||.|||
Human   137 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKC 201

  Fly   202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKD 266
            :|.|..|||.:|||:||||||:||||.|.||||||:|::|||.||||:|.|:||||.|.|...||
Human   202 SMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKD 266

  Fly   267 LIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLN 331
            ||.:.|.|||..|:|.::.|:||||.:
Human   267 LISRLLQVDPEARLTAEQALQHPFFER-------------------------------------- 293

  Fly   332 SSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSAL 396
              |.|:
Human   294 --CEGS----------------------------------------------------------- 297

  Fly   397 ASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPT 461
                             ||.
Human   298 -----------------QPW--------------------------------------------- 300

  Fly   462 VQLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCAFRVY 526
                   ....|::|:.|:..:.|..|:........||.....:||||.::.:|.:||.||||:|
Human   301 -------NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLY 358

  Fly   527 GHWVKKGEGQNRAALFENTP 546
            ||||||||.|||||||::.|
Human   359 GHWVKKGEQQNRAALFQHRP 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	165/271 (61%)
PHKG2	NP_000285.1	STKc_PhKG2	13..291	CDD:271083	169/278 (61%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		4/23 (17%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		17/23 (74%)