Protein Alignment PhKgamma and PHKG1

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_016867813.1
• Gene: PHKG1 / 5260
• HGNCID: 8930
• Length: 432
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 218/599 - (36%)
• Similarity: 279/599 - (46%)
• Gaps: 227/599 - (37%)

  Fly     7 DDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNP---Y 68
            |:.|||..:|:.||..||||||||||:||.|||||.|.|.:|:|.|:||:   |..|..:|   .
Human     4 DEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDV---TGGGSFSPEEVR 65

  Fly    69 HMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTI 133
            .:.|||.:|:.|||:|.|||.||.|:|.:|::.|.||||:|..:||||||||..||||||:||.|
Human    66 ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKI 130

  Fly   134 MRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKL-------------- 184
            ||.:.|.:..:|..:||||||||||||||:|.|:|:|||||:.||:.||:|
Human   131 MRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLRVETGFHHVGQAGL 195

  Fly   185 -------------------------------TNLCGTPGYLAPETLKCNMFEGSPGYSQEVDIWA 218
                                           :.:||||.|||||.::|:|.|..|||.:|||:|:
Human   196 ELLTLRSARLGLPKCCDYRREPPCPAGLGISSEVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWS 260

  Fly   219 CGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVK 283
            .||||:|||.|.|||||||||:|||.||.|.|.|.||||.|.|:..|||:.:.|||.|..|.|.:
Human   261 TGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAE 325

  Fly   284 EVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLNSSCAGAPNYLYCAPQSS 348
            |.|.|||| |..|:.:.||
Human   326 EALAHPFF-QQYLVEEVRH---------------------------------------------- 343

  Fly   349 YSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSALASASSHKTLTAMVYYQQ 413
                                                                             
Human   344 ----------------------------------------------------------------- 343

  Fly   414 QPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPTVQLRKQSRFNARKKFQF 478
                                                                    |:.|.||:.
Human   344 --------------------------------------------------------FSPRGKFKV 352

  Fly   479 AILVIRAIIRI----RRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCAFRVYGHWVKKGEGQNRA 539
            ..|.:.|.:||    ||::    |:..|..|||||.::.||::||..|||:||||||||:.||||
Human   353 IALTVLASVRIYYQYRRVK----PVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRA 413

  Fly   540 ALFENTPRTELHAL 553
            |||||||:..|.:|
Human   414 ALFENTPKAVLLSL 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	162/319 (51%)
PHKG1	XP_016867813.1	Protein Kinases, catalytic domain	16..336	CDD:473864	165/323 (51%)