Protein Alignment PhKgamma and Phkg2

DIOPT Version :10

• Sequence 1: NP_511129.3
• Gene: PhKgamma / 32120
• FlyBaseID: FBgn0011754
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_542151.1
• Gene: Phkg2 / 140671
• RGDID: 620024
• Length: 406
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 214/540 - (39%)
• Similarity: 276/540 - (51%)
• Gaps: 169/540 - (31%)

  Fly     7 DDLLPDKDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHML 71
            :|.|||..|||.||.||:||:|:|||:||.||||:.:.||.|||.||:::.|...|.| ....:.
  Rat     8 EDELPDWAAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLE-QLEEVR 71

  Fly    72 EATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQ 136
            :|||:|:.|||||.|||:||.|.|.:||.:|:||||:|..|||||||||..|.||||:||:|||.
  Rat    72 DATRREMHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136

  Fly   137 IFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGEKLTNLCGTPGYLAPETLKC 201
            :.|.|.::|..:||||||||||||||:|..::::||||:..|:.||||..|||||||||||.|||
  Rat   137 LLEAVNFLHVNNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKC 201

  Fly   202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADISEDPKD 266
            :|.|..|||.:|||:||||||:||||.|.||||||:|::|||.||||:|.|:||||.|.|...||
  Rat   202 SMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKD 266

  Fly   267 LIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPEASSYRFGQLN 331
            ||.|.|.|||:.|:|.::.|:||||.:
  Rat   267 LIAKLLQVDPNARLTAEQALQHPFFER-------------------------------------- 293

  Fly   332 SSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATCHVMSPSNASNSYATNTTANTSNSAL 396
              |.|:
  Rat   294 --CKGS----------------------------------------------------------- 297

  Fly   397 ASASSHKTLTAMVYYQQQPQQHQTQQQQQQYQQQQTTQLPVQLQLQHPLLQTGGDGKQSVYAPPT 461
                             ||.
  Rat   298 -----------------QPW--------------------------------------------- 300

  Fly   462 VQLRKQSRFNARKKFQFAILVIRAIIRIRRLRFTAEPLHVEEAIRDPYRVKVLRKVIDGCAFRVY 526
                   ....|::|:.|:..|.|..|:........||.....:||||.::.:|::||.||||:|
  Rat   301 -------NLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKNALLRDPYALRPVRRLIDNCAFRLY 358

  Fly   527 GHWVKKGEGQNRAALFENTP 546
            ||||||||.|||||||::.|
  Rat   359 GHWVKKGEQQNRAALFQHQP 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	165/271 (61%)
Phkg2	NP_542151.1	STKc_PhKG2	13..291	CDD:271083	169/278 (61%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		5/23 (22%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		17/23 (74%)