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Protein Alignment PhKgamma and CHEK2

DIOPT Version :10

Sequence 1:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_011528141.1	Gene:	CHEK2 / 11200	HGNCID:	16627	Length:	596	Species:	Homo sapiens

Alignment Length:	379	Identity:	136/379 - (35%)
Similarity:	191/379 - (50%)	Gaps:	57/379 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLLPDKDAA--KGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIID-----LGATTESGET 65
            ||..|..:.  |....:|...:.||.|....|:...|::|.|:.|.|||.     :|:..|:
Human   256 DLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREA--- 317

  Fly    66 NPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKT 130
            :|...:|.   ||.||:: :.||.||.:::.|:::.: ::|.||...|||||.:.....|.|...
Human   318 DPALNVET---EIEILKK-LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATC 377

  Fly   131 RTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVKITDFGFAKQLQEGEKLTNLCGTPG 192
            :....|:...|:|:|...|:||||||||:||   :|:..:||||||.:|.|.|...:..|||||.
Human   378 KLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 442

  Fly   193 YLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPF-WHRKQMVMLRNIMEGKYSFTSPE 256
            |||||.|   :..|:.||::.||.|:.|||:|..|.|.||| .||.|:.:...|..|||:|....
Human   443 YLAPEVL---VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEV 504

  Fly   257 WADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQMVLMGDRRHPAPPIAPAQTNSRHLLQPE 321
            ||::||...||::|.|||||..|.|.:|.||||:                           ||.|
Human   505 WAEVSEKALDLVKKLLVVDPKARFTTEEALRHPW---------------------------LQDE 542

  Fly   322 ASSYRFGQL----NSSCAGAPNYLYCAPQSSYSSNRMRDGALDDAGASAASATC 371
            ....:|..|    |.|.| .|..|   .|.|.|..|.|:|..:.|..:...|.|
Human   543 DMKRKFQDLLSEENESTA-LPQVL---AQPSTSRKRPREGEAEGAETTKRPAVC 592

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.