DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXB2 and zen2

DIOPT Version :9

Sequence 1:	NP_002136.1	Gene:	HOXB2 / 3212	HGNCID:	5113	Length:	356	Species:	Homo sapiens
Sequence 2:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster

Alignment Length:	226	Identity:	77/226 - (34%)
Similarity:	104/226 - (46%)	Gaps:	41/226 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   143 ARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREP 207
            ::|.|||:::.||:|||:|||.||||.|.||:||:..|.|||||||:||||||||.|:.| :|:.
  Fly    43 SKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKST-NRKG 106

Human   208 PDGE-----PACPGALEDI--CDPAEEPAASPGGPSASRAAWEACCH----PPEVVPGALSAD-- 259
            ..|.     |....:.||:  .|...|........:...|......|    ..::.|...|.|
  Fly   107 AIGALTTSIPLSSQSSEDLQKDDQIVERLLRYANTNVETAPLRQVDHGVLEEGQITPPYQSYDYL 171

Human   260 ----PRPLAV------RLEGAGASSPGCALRGAGGLEPG-PLPEDVFS-GRQDSPFLPDLNFFAA 312
                |.|:|:      ..:...|||       ..||||. |:.|:|.. ..||.|.:.:   |..
  Fly   172 HEFSPEPMALPQLPFNEFDANWASS-------WLGLEPTIPIAENVIEHNTQDQPMIQN---FCW 226

Human   313 DSCLQLSGGLSPSLQGSLDSPVPFSEEELDF 343
            |     |...|.|....||....|.:..|:|
  Fly   227 D-----SNSSSASSSDILDVDYDFIQNLLNF 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXB2	NP_002136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..142
		Antp-type hexapeptide	94..99
		Homeobox	147..199	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..240		10/49 (20%)
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810