Protein Alignment Ptp10D and ptprb

DIOPT Version :10

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: NP_001131088.2
• Gene: ptprb / 100192375
• XenbaseID: XB-GENE-991728
• Length: 2326
• Species: Xenopus tropicalis
• Alignment Length: 1591
• Identity: 473/1591 - (29%)
• Similarity: 743/1591 - (46%)
• Gaps: 239/1591 - (15%)

  Fly    74 PNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVTIT---------------TAP 123
            |...:.|:| ..|..|:....|.||                 ..|:|               |.|
 Frog   833 PVNKVLSKE-AKEFTFNHLAQGRKY-----------------IATVTSISGDLSSRASVEGRTVP 879

  Fly   124 DPPSNLSVQVRSGKNAIIL-W--SPPTQGSYTAFKI--KVLGLSEASSSYNRTFQVNDNTFQHSV 183
            ...:||:|:.:...:::.. |  :|....||....|  |::..:|..|:     ::|..:| ||:
 Frog   880 AQVTNLNVENQGTTSSLHADWTKAPGDVDSYQVLLIHEKIVIKNETVSN-----EINKYSF-HSL 938

  Fly   184 KELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTH 248
            |   ||..|.|...|:..|..|....|...|...:.....|..|.....|.:.|||  .||....
 Frog   939 K---PGGLYSVVVTTVSGGISSRQTVSEGRTVPSSVNRVTINNFGRSDYLSISWQP--AAGDVDI 998

  Fly   249 YKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMS--------EDEISLPTT 305
            |.|::...:.....|.:.|...     :.:|..|..||.||::|.|.|        ..|.::|:.
 Frog   999 YFVTLSHQNNILPSLAISKSVN-----ECSFSSLTAGRLYNVTVTTKSGKYENHSYSQEWTVPSA 1058

  Fly   306 AQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFD 370
            .|...|     |.....|::.::..|       .:.:||.|||         |:..:|:   |..
 Frog  1059 VQGLAV-----NNAARSDYLKASWLR-------AVGDFDIYQV---------TIKNNND---FIQ 1099

  Fly   371 FRDIAE-----------PGKTFNVIVKTVSGKVTSWPATGDVTLRPLP--VRNLRSINDDKTNTM 422
            .:|:.:           ||:.:::.|.|.||   ::.|:...:.|..|  |:.| ::.:..:..:
 Frog  1100 IKDVTKTENECVFTNLVPGRLYSITVMTKSG---NYKASAMASGRTFPEAVKKL-TLAERSSEEL 1160

  Fly   423 IITW-EADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESN 486
            .:|| .||......|.::::::::.|...|...|.|..:||  ||.|||.|.:.|...|.:.
 Frog  1161 HVTWSRADGDVDHYEIQLLFNDMKVFPPITLNNTADEYKFT--SLTPGRLYKIVVLTFSGEA--- 1220

  Fly   487 ETSIFV--VTRPSSPIIEDLKSIRM-------GLNISWK---SDVNSKQEQYEV-LYSRNGTSDL 538
            :.::||  :|.||:     :|:|.:       .|.::|.   .||:|    |.| ::..|.....
 Frog  1221 QRAMFVEALTVPST-----VKNIHISPNGMTNSLKVNWTPGGGDVDS----YTVSIFHHNSPIGS 1276

  Fly   539 RTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVL-VH 602
            .|..........:||.||..|::.|...|..|.....::.:.: |....:::.:...|:.:| |.
 Frog  1277 HTTSKHIFEHTFQNLNPGELYKVDVQTNSGSLHKSLESFGRTI-PATVHSLSADNAYSSHLLIVS 1340

  Fly   603 WSPPESGEFTEYSIRYRTDSEQQWVRLPS----VRSTEADITDMTKGEKYTIQVNTVSFGVESPV 663
            |...: |....|.|...:|   ..:.:.:    :.:......|:..|:||.|||.|||.|:.|..
 Frog  1341 WQSAK-GVTDRYDILLLSD---HGIVITNKSVPIMAKSHKFEDLVPGKKYRIQVFTVSGGLFSAA 1401

  Fly   664 PQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSAD 727
            .:....|||. .||:: |....:.:::..|...||.::||.:..:..||       ::.:.||.:
 Frog  1402 VETEGQTVPA-AVSDVKITGNSTDSLSFTWNSSEGELDSYGIFLYNPDN-------SLHDRKSGN 1458

  Fly   728 -DLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITL 791
             ||.  ......|:||..||..|.|.| |.|:..:|::.||:|...|.:.|:|....:     :|
 Frog  1459 PDLR--HCSFQGLLPGRLYKMVIVTHS-GSLTNESSIHGRTVPAPVSSLQVSNRNTSE-----SL 1515

  Fly   792 SYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPI 856
            .:|..| :....|||...|.:....:|||:.:....:..|..|||||||.:.::|.||.:.: ..
 Frog  1516 WFTWAP-ALGDVDIYELILYNPNGTEKEKIQDKDLTESHFQNLVPGRLYTLVIFTHSGDLFN-KA 1578

  Fly   857 QRQDRLYPEPITQLHATNITDTEISLRWDLPKG--EYNDFDIAYLTADNLLAQNM----TTRNEI 915
            ....|..|:|...:...::....:|:.|..|..  :|:||::.:...|.|:..|.    .::..|
 Frog  1579 TAVGRTAPQPPNSVSFADVKINSLSIMWLGPPDWTDYDDFELQWSPKDLLVVVNPYSIGRSKGRI 1643

  Fly   916 TISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSL 980
             |:.|.|.|.|||.|...||.....|   ||  |.|.|....|.::...|......:.|:..|:.
 Frog  1644 -INGLYPGRQYTFGVQSVSGNTGKTL---SP--AIFGTVRTKPDKIHHLHCRPQTSTAISCSWTP 1702

  Fly   981 PSSEANGVIRQFSIAYTNINNLTDAGM-QDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPER 1044
            |.|:.:|    :|:.... |...|... :..|.:::...|..|.|.:.||..|:..:|.......
 Frog  1703 PDSDFDG----YSVECRR-NGSDDVEFSKRIEKDKSSITISTLVPHKRYVVSIKVHSADMTSQVI 1762

  Fly  1045 EYRQTMPILAPPRP--ATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAE----DDAK 1103
            |......|..||.|  ..:|...:.:.|.|:|..||..::|||.||.|:.:|:||:|    |:.:
 Frog  1763 EDSAITMIDRPPPPPLLIRVNKKDTFISKSSIHFRFNCSWFSDTNGAVKYFTVIVSEADGNDNQR 1827

  Fly  1104 NASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTI---------GTE----NCDNHKIG 1155
            ..:.|.:||:.|.::......||.  .|:|.......|:.|         |.|    .||.::..
 Frog  1828 PEASLPLPSYADYKTNKSTKIYQT--SYFPSRCAENPDYNIQSYKIKLGTGMELLGGKCDQNENK 1890

  Fly  1156 YCNGPLKSGTTYRVKVRAFT----------GADKFTDTAYSFPIQTDQDNT-SLIVAITVPLTII 1209
            ||:|||...|:||:.|||||          ....::||.:|.||.|:.:.. .:|..::..:.:|
 Frog  1891 YCDGPLSPRTSYRISVRAFTQLFTEEMRTFPEPLYSDTFFSLPITTEAEPLFGVIEGVSGGMFVI 1955

  Fly  1210 LVLLV--TLLFYKRRRNNCRK----TTKDSRAND----------NMSLPDSVIEQNRPILIKNFA 1258
            ::::|  .||.|::::....:    ||..|...:          ::.:.|.:  .:||||...|.
 Frog  1956 IMIIVLTVLLIYRQKKKRVYEQDPMTTHLSSQIERIPSVHLNVGHIQIGDRI--SSRPILTAQFE 2018

  Fly  1259 EHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEG 1323
            ||:..:..||::..|.|:|.||..||||....|.||.||.|||::||||||.:|.||..||||..
 Frog  2019 EHFSKLQTDSNYLLSREYENLKDFGRDQSSDTALLPENRGKNRYSNILPYDSTRVKLANVDDDPC 2083

  Fly  1324 SDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND 1388
            ||||||:|:||.|..||:|.|||||.:|:||||:|.||.|...|||:|:|.|:||.|||.|||.|
 Frog  2084 SDYINASYMPGINFRREYIATQGPLPATKDDFWKMVWEQNVHIIVMVTQCTERGRAKCDHYWPMD 2148

  Fly  1389 TVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSE---QRILRHFHFTTWPDFGVPNPPQTLVRFV 1450
            ....:|||:.||:|::|...:|.:.||.:|...:   .|::||||:|.|||.|||...|:|::||
 Frog  2149 QDSYYYGDLIVQMLSESVLPEWTIREFKICSEDQIDAPRLVRHFHYTVWPDHGVPETTQSLIQFV 2213

  Fly  1451 RAFRDRIGAE--QRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQT 1513
            |..||.|...  ..|.||||||||||:||||.|||:|||::|.|.|||||.|..:|..|::||||
 Frog  2214 RTVRDYINRTPGSGPTVVHCSAGVGRTGTFIVLDRMLQQVDTVDSVDIFGAVRDLRIHRMYMVQT 2278

  Fly  1514 EQQYICIHQCLLAVLEGKENIVGPAREMHDN 1544
            |.||:.::||:..||..::     .|...||
 Frog  2279 ECQYVYLYQCVRDVLRARK-----LRNEQDN 2304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996	22/85 (26%)
		fn3	220..304	CDD:394996	22/91 (24%)
		FN3	278..>734	CDD:442628	117/497 (24%)
		FN3	583..671	CDD:238020	21/92 (23%)
		fn3	787..850	CDD:394996	20/62 (32%)
		fn3	866..935	CDD:394996	19/74 (26%)
		fn3	959..1043	CDD:394996	17/84 (20%)
		PTP_tm	1083..1187	CDD:465889	40/130 (31%)
		R3-PTPc	1301..1522	CDD:350396	125/225 (56%)
ptprb	NP_001131088.2	beta-trefoil_Ricin_PTPRB-like	18..132	CDD:467787
		Herpes_BLLF1	<131..520	CDD:282904
		FN3	528..597	CDD:473895
		fn3	613..690	CDD:394996
		fn3	705..779	CDD:394996
		fn3	793..872	CDD:394996	10/56 (18%)
		fn3	881..954	CDD:394996	21/81 (26%)
		fn3	981..1045	CDD:394996	19/70 (27%)
		fn3	1057..1133	CDD:394996	20/102 (20%)
		fn3	1146..1219	CDD:394996	21/75 (28%)
		fn3	1233..1306	CDD:394996	18/81 (22%)
		FN3	1326..1399	CDD:473895	19/76 (25%)
		fn3	1412..1491	CDD:394996	24/88 (27%)
		fn3	1500..1573	CDD:394996	23/78 (29%)
		fn3	1588..1669	CDD:394996	22/84 (26%)
		fn3	1681..1760	CDD:394996	17/83 (20%)
		PTP_tm	1798..1935	CDD:465889	43/138 (31%)
		R-PTPc-B	2060..2287	CDD:350465	126/226 (56%)