DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXB1 and Antp

DIOPT Version :9

Sequence 1:	NP_002135.2	Gene:	HOXB1 / 3211	HGNCID:	5111	Length:	301	Species:	Homo sapiens
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	102/358 - (28%)
Similarity:	128/358 - (35%)	Gaps:	97/358 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDYNRMNSFLEYPLCN-RGPSAYSAHSAPTSFPPSSAQAVDSYASEGRYGGGLSSPAFQQ----- 59
            |.|.|...:...|..| :|......|.. .|.|.|.:..|.....:.:..|.|..|..||
  Fly    55 MPYPRFPPYDRMPYYNGQGMDQQQQHQV-YSRPDSPSSQVGGVMPQAQTNGQLGVPQQQQQQQQQ 118

Human    60 ----NSGYPAQQPPSTLGVPFP------------SSAPSGYAPAACSPSYGPSQYYPLGQS---- 104
                .....|||.|..|....|            ...|..||......:.|.....|.|.|
  Fly   119 PSQNQQQQQAQQAPQQLQQQLPQVTQQVTHPQQQQQQPVVYASCKLQAAVGGLGMVPEGGSPPLV 183

Human   105 -EGDGGYF-----------HPSSYGAQLG----GLSD-------GYGAG------GAGPGPYPPQ 140
             :..|.:.           ||.   ||||    |:.|       .:..|      |..|...|||
  Fly   184 DQMSGHHMNAQMTLPHHMGHPQ---AQLGYTDVGVPDVTEVHQNHHNMGMYQQQSGVPPVGAPPQ 245

Human   141 ---HPPYGNEQTASFAPAYADLLSEDKETPCPSEPNTPT----ARTFDWMKVKRNPPKTAKVSEP 198
               |...|..|.....|.        :.||....||:.:    :..:.||:     .:..|..|.
  Fly   246 GMMHQGQGPPQMHQGHPG--------QHTPPSQNPNSQSSGMPSPLYPWMR-----SQFGKCQER 297

Human   199 GLGSPSGLRTNFTTRQLTELEKEFHFNKYLSRARRVEIAATLELNETQVKIWFQNRRMKQKKRER 263
            ..|     |..:|..|..|||||||||:||:|.||:|||..|.|.|.|:||||||||||.||..:
  Fly   298 KRG-----RQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENK 357

Human   264 EEGRVPPAPPGCPKEAAGDASDQSTCTSPEASP 296
            .:|.     ||     :|...|:.|   |..||
  Fly   358 TKGE-----PG-----SGGEGDEIT---PPNSP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXB1	NP_002135.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..77		15/65 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..149		8/30 (27%)
		Antp-type hexapeptide	179..184		1/4 (25%)
		Homeobox	207..259	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..301		15/43 (35%)
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	33/165 (20%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	34/52 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810