DRSC/TRiP Functional Genomics Resources

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Protein Alignment Polr2A and POLR1A

DIOPT Version :10

Sequence 1:NP_511124.1 Gene:Polr2A / 32100 FlyBaseID:FBgn0003277 Length:1887 Species:Drosophila melanogaster
Sequence 2:NP_056240.2 Gene:POLR1A / 25885 HGNCID:17264 Length:1720 Species:Homo sapiens


Alignment Length:1836 Identity:468/1836 - (25%)
Similarity:741/1836 - (40%) Gaps:508/1836 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PLRQVKRVQFGILSPDEIRRMSVTE-GGVQFAETMEGGRPKLGGLMDPRQGVIDRTSRCQTCAGN 73
            |.|:::.:.||:.|.:|::::||.. ...::.:::  |.|...||.|...|..|....|.||..:
Human     8 PWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSL--GNPSANGLYDLALGPADSKEVCSTCVQD 70

  Fly    74 MTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPH-------------------- 118
            .:.|.||.|||:|...|::.....|...:||..|..| .||..|.                    
Human    71 FSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNC-HMLTCPRAVIHLLLCQLRVLEVGALQA 134

  Fly   119 ----------------NPKIKEI---------------VMKSRGQPRKRLAYVYDLCKGKT---- 148
                            :|...||               ::.|:|      |:|.::|:.|:    
Human   135 VYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQG------AHVKNVCESKSKLIA 193

  Fly   149 -------------ICEGGEDM-------DLT------------KENQQPDPNKKPGHGGCGHYQP 181
                         .|:.|..:       .||            :::.:|...::...|..|:..|
Human   194 LFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDSEPLGIEEAQIGKRGYLTP 258

  Fly   182 SIRRTGLDLTAEWKHQNEDSQEKKIVVSAERVWEILKHI---TDEECFILGMDPKYARPDWMIVT 243
            :..|.  .|:|.||::.                ..|.::   .|::    ||:.:: .|....:.
Human   259 TSARE--HLSALWKNEG----------------FFLNYLFSGMDDD----GMESRF-NPSVFFLD 300

  Fly   244 VLPVPPLAVRPAVVMFGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENIK-------- 300
            .|.|||...|| |...|.....:..|..|..::|....:||..|..|....:.|.:.        
Human   301 FLVVPPSRYRP-VSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTTDEEK 364

  Fly   301 ----------------------------MLQFHVATLVDNDM--------PGMPRAMQKSGKPLK 329
                                        .||.||..:.|::|        ||:.:.::|      
Human   365 DSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEK------ 423

  Fly   330 AIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRIDQVGVPRSIAQNLTFPELVTPFNIDRM 394
                    |||..|.::||||||::||:||.||..:..:::|:|...|..||:|:.|||:|:..:
Human   424 --------KEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL 480

  Fly   395 QELVRRGNSQYPGAKYIVRDNGER-----IDLRFH--------------PKSSDLHLQCGYKVER 440
            ::.|..|.:.:|||..::.::|.|     :|:...              ||.....:.|     |
Human   481 RQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVC-----R 540

  Fly   441 HLRDDDLVIFNRQPTLHKMSMMGHRVKVLP-WSTFRMNLSCTSPYNADFDGDEMNLHVPQSMETR 504
            |:::.|:::.|||||||:.|:..||.::|| ....|::.:....|||||||||||.|.|||...|
Human   541 HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGR 605

  Fly   505 AEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLPTWD----AK 565
            ||...:..|.:|.:.|:..:|:.|::||.:.:...||.|..|.|||..|. |::....|    .|
Human   606 AEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYME-LVYRGLTDKVGRVK 669

  Fly   566 MPQPCILKPRPLWTGKQIFSLIIPGNVNMIRTHSTHPDEEDEGPYK-----------WIS----- 614
            :..|.||||.|||||||:.|.::   :|:|        .||..|..           |:.     
Human   670 LLSPSILKPFPLWTGKQVVSTLL---INII--------PEDHIPLNLSGKAKITGKAWVKETPRS 723

  Fly   615 -PG-------DTKVMVEHGELIMGILCKKSLGTSAGSLLHICFLELGHDIAGRFYGNIQTVINNW 671
             ||       :::|::..|||:.|:|.|...|:||..|:|.|:...|.:.:|:....:..:...:
Human   724 VPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFTAY 788

  Fly   672 L-LFEGHSIGIGDTIADPQTYNEIQQAIKKAK-------------------DDVINVIQKAHNME 716
            | |:.|.::|:.|.:..|:...:.|:.|:::.                   |:|....|.|| :.
Human   789 LQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAH-LG 852

  Fly   717 LEPTPGNTLRQTFENKVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVG 781
            .:....|.:...|:.:||...|:................|:|:.||.||:|||.:|..|:...:|
Human   853 KDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQISCLLG 917

  Fly   782 QQNVEGKRIPYGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKT 846
            |..:||:|.|.....::||.|...::.|.:.|||...:|.|:.|.||:||.|.|||||:||||||
Human   918 QIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKT 982

  Fly   847 AETGYIQRRLIKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEKR 911
            :.:||:||.:||.:|.::|.||.|||:|.|.::|..||||||        ::|..:...   .|:
Human   983 SRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGL--------DIPKTQFLQ---PKQ 1036

  Fly   912 FKFDWSN-ERLMKKVFTDDVIKEMTDSSEAIQELEA--EWDRLVSDRDSLRQIFPNGESKVVLPC 973
            |.|..|| |.:||.....:|:.. .|..:|:....|  :|.....:....|..|.:...|:    
Human  1037 FPFLASNYEVIMKSQHLHEVLSR-ADPKKALHHFRAIKKWQSKHPNTLLRRGAFLSYSQKI---- 1096

  Fly   974 NLQRMIWNVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQ---- 1034
              |..:    |...:........||     |.:.:|          |:..:.:|.:...:|    
Human  1097 --QEAV----KALKLESENRNGRSP-----GTQEML----------RMWYELDEESRRKYQKKAA 1140

  Fly  1035 -C------LIRSTLCTKYVSEEFRLSTEAF--EW-----------------LVGEIETRFQQAQA 1073
             |      :.|..:....|||.|....:.:  ||                 |...::.::|::..
Human  1141 ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKWQRSLC 1205

  Fly  1074 NPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEIINI-SKKPKAP--SLTVFL 1135
            .|||.||.|||||:|||:||||||||||||....|||||:|||:||:.: |...|.|  |:.|..
Human  1206 EPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLN 1270

  Fly  1136 TGGAARDAEKAKNVLCR----------------------------------LEH----------- 1155
            |..|.:..:..|..|.|                                  |.|           
Human  1271 TKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQFLPHAYYQQEKCLRP 1335

  Fly  1156 --------------------------TTLRKVTANTAIYYDPD----------PQRTVISEDQEF 1184
                                      :..|.|....|...|.|          .|.....|:...
Human  1336 EDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNAGELGRSRGEQEGDEEEEGHI 1400

  Fly  1185 VNVYYEMPDFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNCIFNDDNADKLVL 1249
            |:...|..|.|.:           |.||...::..::..:|:.....||:     |||..     
Human  1401 VDAEAEEGDADAS-----------DAKRKEKQEEEVDYESEEEEEREGEE-----NDDED----- 1444

  Fly  1250 RIRIMNNEEN-------KFQDEDEAVD-KMEDDMFLRCI---EANMLSDMTLQGIEAIGK----- 1298
                |..|.|       |.|::||.|. ..|:|..|..:   ..........||.||:.:     
Human  1445 ----MQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMERRVQAV 1505

  Fly  1299 ---------------------VYMHLP----------------------QTDSKKRIVITETGEF 1320
                                 |.:.||                      .|....|.::.||...
Human  1506 REIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGITRCLLNETTNN 1570

  Fly  1321 KAIGEWLLETDGTSMMKVLSERDV-DPIRTSSNDICEIFQVLGIEAVRKSVEKEMNAVLQFYGLY 1384
            |...|.:|.|:|.::.::....:| |..|..||||..|....||||..:.:|||:..|...||:.
Human  1571 KNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIA 1635

  Fly  1385 VNYRHLALLCDVMTAKGHLMAITRHGINRQDTGALMRCSFEETVDVLMDAAAHAETDPMRGVSEN 1449
            |:.|||:|:.|.|..:|....:.|.|| |.::..|.:.:||.:...|..|......|.:|..|..
Human  1636 VDPRHLSLVADYMCFEGVYKPLNRFGI-RSNSSPLQQMTFETSFQFLKQATMLGSHDELRSPSAC 1699

  Fly  1450 IIMGQLPKMGTGCFDL 1465
            :::|::.:.|||.|:|
Human  1700 LVVGKVVRGGTGLFEL 1715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Polr2ANP_511124.1 RNAP_II_RPB1_N 15..868 CDD:259848 278/1055 (26%)
RNA_pol_Rpb1_6 890..1071 CDD:461511 36/213 (17%)
RNAP_II_Rpb1_C 1050..1468 CDD:132720 143/579 (25%)
Herpes_BLLF1 <1498..1862 CDD:282904
PTZ00449 <1707..1880 CDD:185628
POLR1ANP_056240.2 RNAP_I_RPA1_N 16..1004 CDD:259844 278/1052 (26%)
Clamp. /evidence=ECO:0000269|PubMed:34671025 110..201 11/96 (11%)
Clamp. /evidence=ECO:0000269|PubMed:34671025 320..426 18/119 (15%)
Rudder. /evidence=ECO:0000269|PubMed:34671025 403..416 2/12 (17%)
Involved in RRN3 binding to Pol I complex. /evidence=ECO:0000269|PubMed:34887565 468..542 17/78 (22%)
Funnel. /evidence=ECO:0000269|PubMed:34671025 805..883 13/78 (17%)
RNA_pol_Rpb1_5 958..1670 CDD:398596 200/774 (26%)
Bridging helix. /evidence=ECO:0000250|UniProtKB:G3MZY8, ECO:0000269|PubMed:34671025 960..1001 24/40 (60%)
Mediates the interaction with TOP2A. /evidence=ECO:0000269|PubMed:36271492 1060..1155 18/119 (15%)
Trigger loop. /evidence=ECO:0000250|UniProtKB:G3MZY8 1207..1248 31/40 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1365..1498 34/157 (22%)
Blue background indicates that the domain is not in the aligned region.

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