Protein Alignment Polr2A and rpc1

DIOPT Version :10

• Sequence 1: NP_511124.1
• Gene: Polr2A / 32100
• FlyBaseID: FBgn0003277
• Length: 1887
• Species: Drosophila melanogaster
• Sequence 2: NP_595506.1
• Gene: rpc1 / 2541094
• PomBaseID: SPBC651.08C
• Length: 1405
• Species: Schizosaccharomyces pombe
• Alignment Length: 1547
• Identity: 515/1547 - (33%)
• Similarity: 781/1547 - (50%)
• Gaps: 241/1547 - (15%)

  Fly     1 MSTPTDSKAPLRQVKRVQFGILSPDEIRRMSVTEGGVQFAE----TMEGGRPKLGGLMDPRQGVI 61
            |..|.|.:.| :::|.:||||..|:|.    |.:|.|:.:.    ||....|...|.:|...|..
pombe     1 MKDPIDDQIP-KRIKHLQFGINGPEEF----VKDGTVEVSRRDLYTMTDRSPAEHGALDLHMGTS 60

  Fly    62 DRTSRCQTCAGNMTECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPK--IKE 124
            ::...|.||..:|.:|.||||::.||.||||||:...|:.||:.:|..||.:|:|....:  :|:
pombe    61 NKQINCATCGESMADCMGHFGYVKLALPVFHIGYFKATLTILQNICKDCSSVLLSDQEKRQFLKD 125

  Fly   125 IVMKS-----RGQPRKRLAYVYDLCKGKTICEGGEDMDLTKENQQPDPNKKPGHGGCGHYQPSIR 184
            :....     |.|..||   :.|.||....|        :|.:......||.|.....|.:....
pombe   126 LRRPGIDNLRRSQICKR---INDHCKKMRRC--------SKCDAMQGVVKKAGPLKIIHERFRYV 179

  Fly   185 RTGLDLTAEWKHQNEDS----QEKKIVVSAE-------RVWEILKHITDEECFILGMDPKYARPD 238
            |...|....::|..:::    .|.|:.:|..       :|..:.|.||..:|.:|||||::.||:
pombe   180 RKSQDDEENFRHSFDEALKTIPELKMHLSKAHDDLNPLKVLNLFKQITPVDCELLGMDPEHGRPE 244

  Fly   239 WMIVTVLPVPPLAVRPAVVMFGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENIKMLQ 303
            .::...:|.||:.:||:|...||. .:||||.|:::||..::.:|...:.|.....:.|..:.:|
pombe   245 NLLWRYVPAPPVCIRPSVAQEGAT-TEDDLTVKITEIIWTSSLIRAALSKGTPISNLMEQWEFMQ 308

  Fly   304 FHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPNLRID 368
            ..:|..::::|||: |......||::....|||||:||.||||.|||||||.||||:||||||||
pombe   309 LSIAMYINSEMPGL-RPSDMPSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRID 372

  Fly   369 QVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIV-RDNGERIDLRFHPKS--SDL 430
            ||.||..||:.|||||.||..|...:|:.:|.|...:|||.|:: |::|.:..|||..::  :|
pombe   373 QVAVPYRIAKILTFPERVTTQNKKHLQDCIRNGPDVHPGANYVIDRESGFKRFLRFGNRNRIAD- 436

  Fly   431 HLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSCTSPYNADFDGDEMNL 495
            .|:.|..|||||.|:|:|:|||||:|||:|:|.|.|||.||.|.|.|.....|||||||||||||
pombe   437 DLKIGDIVERHLHDNDVVLFNRQPSLHKLSIMAHLVKVRPWRTLRFNECVCGPYNADFDGDEMNL 501

  Fly   496 HVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVFITREQVMNLLMFLP 560
            ||||:.|.:.|...:......:::|:..:|::...||.:||...::.:|.|:.|:.:.|:..::
pombe   502 HVPQTEEAKTEALELMGIKNNLVSPRNGEPIIAATQDFITAAYLLSLKDTFLDRKSISNICCYM- 565

  Fly   561 TWDAK----MPQPCILKPRPLWTGKQIFSLIIPGN------VNM---IRTHSTHPDEEDEGPYKW 612
             .||.    :|.|.|:|||.||||||:|::::..|      ||:   .|:.|....:..|
pombe   566 -MDASTHIDLPPPAIIKPRCLWTGKQVFTVLMKPNRFSKVLVNLDAKTRSFSRIKSKTPE----- 624

  Fly   613 ISPGDTKVMVEHGELIMGILCKKSLGT-SAGSLLHICFLELG-----------HDIAGRFYGNIQ 665
            :.|.|..:|:.:.|:|.|::.|..:|. ...||.::...:.|           ..:..||.||
pombe   625 MCPKDGYLMIRNSEIIAGVVDKSVVGDGKKDSLFYVILRDYGALEAAEAITRLSKMCARFLGN-- 687

  Fly   666 TVINNWLLFEGHSIGIGDTIADPQTYNEIQQAIKKA---KDDVINVIQKAHNMELEPTPGNTLRQ 727
                     .|.||||.|........::.:..:.||   .||.|  :|.|..: ||..||.....
pombe   688 ---------RGFSIGIEDVQPGKSLSSQKEILVNKAYATSDDFI--MQYAKGI-LECQPGMDQEA 740

  Fly   728 TFENKVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIPY 792
            |.|.|::..|:..||..|......|...|:...|...|||||.||:||::||||||.:.|||:|.
pombe   741 TLEAKISSTLSKVRDDVGEICMDELGPANSPLIMATCGSKGSKINVSQMVACVGQQIISGKRVPD 805

  Fly   793 GFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRLI 857
            ||:.|:||||.|:...|.::|||.||:.:||||:||.|||:.|||||:|||||||||||:.|||:
pombe   806 GFQDRSLPHFHKNSKHPLAKGFVSNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMSRRLM 870

  Fly   858 KAMESVMVNYDGTVRNSVGQLIQLRYGEDGL-------CGELVEFQN--MPTVKLSNKSFEKRFK 913
            |::|.:...||||||:|...::|..||:|||       .|:.|||:.  :.:|.|:
pombe   871 KSLEDLSSAYDGTVRSSNSDVVQFVYGDDGLDPTYMEGDGQAVEFKRTWIHSVNLN--------- 926

  Fly   914 FDWSNERLMKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRDSLRQIFPNGESKVVLPCNLQRM 978
            :|..:..::.....|.|.:.:.|                              .|.:..||  |.
pombe   927 YDRHDSAMLPYEIIDYVNRALDD------------------------------PKFLTNCN--RD 959

  Fly   979 IWNVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTGNDRISKQANENATLLFQCLIRSTLCT 1043
            .....:.|.| :.:...|:.:|..:.:..:||...:   :|....:.:|.|.:..:
pombe   960 FIETIRTFVI-ENIAKYLASVRERRDLAPMLEEPDM---DDLDDMEGDEFAPVAKR--------- 1011

  Fly  1044 KYVSEEFRLSTEAFEWLVGEIETRFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHFAGVSSKN 1108
            |.|....|::.:.....|.....::.:|:..||..|||:.|||:|||.|||||.|||||||:::
pombe  1012 KSVENIIRVTEKQLRSFVDRCWEKYMRAKVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVAAQ- 1075

  Fly  1109 VTLGVPRLKEIINISKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANTAIYYDPDP 1173
            .||||||:|||||.:|....|.:|..|...  ||...|:.|..|:|.|.|:.||:.....|.|
pombe  1076 TTLGVPRIKEIINAAKTISTPIITGQLIND--RDERSARVVKGRIEKTYLKDVTSYIEEVYGP-- 1136

  Fly  1174 QRTVISEDQEFVNVYYEMP-DFDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINVGFGEDLNC 1237
                       |..|..:. :||.      :.:::||        :|:..||..|
pombe  1137 -----------VTTYLSIQVNFDT------ISKLQLD--------ITLADIAAAI---------- 1166

  Fly  1238 IFNDDNADKLVL------------RIRIMNNEENKFQDEDEAVDKMEDDMFLRC-IEANMLSDMT 1289
                .|..||.:            :|.:..:.:.|         ..|.:::.|. ....:|.|:.
pombe  1167 ----WNTPKLKIPSQQVTVNNTLQQIHVHTSSDGK---------SSETEVYYRLQTYKRVLPDVV 1218

  Fly  1290 LQGIEAIGKVYMHLPQTDSKKRIVITETGEFKAIGEWLLETDGTSMMKVLSERDVDPIRTSSNDI 1354
            :.||..|            .:.::..|:|:.:      |..:||.:..|::...:...:||:|.:
pombe  1219 VAGIPTI------------NRSVINQESGKIE------LFMEGTGLQAVMNTEGIVGTKTSTNHV 1265

  Fly  1355 CEIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRHGINRQDTGAL 1419
            .|:..||||||.|.|:..|:...:..:||.|:.||:.||.||||.||.::.|||.|:.:.....|
pombe  1266 MEMKDVLGIEAARYSIISEIGYTMAKHGLTVDPRHIMLLGDVMTCKGEVLGITRFGVAKMKDSVL 1330

  Fly  1420 MRCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDLLLDAEK 1471
            ...|||:|.|.|.:|||....|.:.|:||.|::|:|..:||..|.|:...|:
pombe  1331 ALASFEKTTDHLFNAAARFAKDSIEGISECIVLGKLAPIGTNVFQLIRRTEE 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2A	NP_511124.1	RNAP_II_RPB1_N	15..868	CDD:259848	340/905 (38%)
		RNA_pol_Rpb1_6	890..1071	CDD:461511	27/182 (15%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	132/431 (31%)
		Herpes_BLLF1	<1498..1862	CDD:282904
		PTZ00449	<1707..1880	CDD:185628
rpc1	NP_595506.1	RNAP_III_RPC1_N	22..885	CDD:259847	339/901 (38%)
		rpoC2	829..>1072	CDD:214368	94/296 (32%)
		RNAP_III_Rpc1_C	1035..1374	CDD:132723	128/409 (31%)