Protein Alignment Polr2A and polr3a

DIOPT Version :10

• Sequence 1: NP_511124.1
• Gene: Polr2A / 32100
• FlyBaseID: FBgn0003277
• Length: 1887
• Species: Drosophila melanogaster
• Sequence 2: NP_001096178.1
• Gene: polr3a / 100124725
• XenbaseID: XB-GENE-1012749
• Length: 1390
• Species: Xenopus tropicalis
• Alignment Length: 1557
• Identity: 512/1557 - (32%)
• Similarity: 778/1557 - (49%)
• Gaps: 298/1557 - (19%)

  Fly    12 RQVKRVQFGILSPDEIRRMSVTEGGVQFAETMEGGRPKLG-GLMDPRQGVIDRTSRCQTCAGNMT 75
            :::..:.||:.|.:::|:.:..:...:...:.:.....|. |::|.|.|..::...||||..|:.
 Frog    12 KKISHICFGVKSAEQMRQQAHIQIVSKSLYSQDNNHTPLAFGVLDHRMGTSEKDRHCQTCGKNLA 76

  Fly    76 ECPGHFGHIDLAKPVFHIGFITKTIKILRCVCFYCSKMLVSPHNPK-----IKE---IVMKSRGQ 132
            ||.||:|::||..|.||:|:....|.||:.:|..||::|::....|     :|.   ..::.||.
 Frog    77 ECLGHYGYLDLELPCFHVGYFKAVIGILQMICKTCSRILLNAEERKQFLDFLKRPGLTYLQKRGL 141

  Fly   133 PRKRLAYVYDLCKGKTICEGGEDMDLTKENQQPDPNKKPGHGGCGHYQPSIRRTGLDLTAEWKHQ 197
            .:|    :.|.|:.||:|.                       .||.|..|:::.||......|::
 Frog   142 KKK----ISDKCRKKTVCL-----------------------YCGAYNGSVKKCGLLKIIHEKYK 179

  Fly   198 N--------------------EDSQEKKIVVSAER-------VWEILKHITDEECFILGMDPKYA 235
            .                    |.::|.:.::...:       |..:|:.|..|:..:|.|:|:..
 Frog   180 TTKKVVDPMVSHFLQSFDTAIEHNKEVESLLGRAQENLNPLIVLNLLRQIPAEDIPLLLMNPEAG 244

  Fly   236 RPDWMIVTVLPVPPLAVRPAVVM-FGAAKNQDDLTHKLSDIIKANNELRKNEASGAAAHVIQENI 299
            :|..:|:|.|.||||.:||:||. ..:..|:||||.||::||..|:.::|:..:||...:|.|:.
 Frog   245 KPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRITGAKTQMIMEDW 309

  Fly   300 KMLQFHVATLVDNDMPGMPRAMQKSGKPLKAIKARLKGKEGRIRGNLMGKRVDFSARTVITPDPN 364
            ..||...|..:::::.|:|..|... |..:....|||||:||.||||.|||||||.||||:||||
 Frog   310 DFLQLQCALYINSELSGIPMNMAPK-KWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPN 373

  Fly   365 LRIDQVGVPRSIAQNLTFPELVTPFNIDRMQELVRRGNSQYPGAKYIVR-----------DNGER 418
            ||||:|.||..:|:.|||||.|...|:..|::||:.|...:|||.:|.:           .|.|:
 Frog   374 LRIDEVAVPVHVAKILTFPEKVNQANMQLMRKLVQNGPDVHPGANFIQQRHTQMKRFLKYGNREK 438

  Fly   419 I--DLRFHPKSSDLHLQCGYKVERHLRDDDLVIFNRQPTLHKMSMMGHRVKVLPWSTFRMNLSCT 481
            |  :|||           |..|||||.|.|:|:|||||:|||:|:|.|..:|.|..|||.|....
 Frog   439 IAQELRF-----------GDIVERHLIDGDIVLFNRQPSLHKLSIMAHIARVKPHRTFRFNECVC 492

  Fly   482 SPYNADFDGDEMNLHVPQSMETRAEVENIHITPRQIITPQANKPVMGIVQDTLTAVRKMTKRDVF 546
            :||||||||||||||:||:.|.:||...:..|...::||:..:|::..:||.|||...:|.:|.|
 Frog   493 TPYNADFDGDEMNLHLPQTEEAKAEAYVLMGTKANLVTPRNGEPLIAAIQDFLTAAYLLTLKDTF 557

  Fly   547 ITREQVMNLL-MFLPTWDAK----MPQPCILKPRPLWTGKQIFSLII-PGNVNMIRTHSTHPDEE 605
            ..|.:...:: ..|...|.|    :|.|.||||..||||||:||||: |.:.|.:|.:.....::
 Frog   558 FDRAKACQIIASILVGKDEKIKVRLPPPAILKPVTLWTGKQVFSLILQPSHDNPVRANLRTKGKQ 622

  Fly   606 DEGPYKWISPGDTKVMVEHGELIMGILCKKSLGT-SAGSLLHICFLELGHDIAGRFYGNIQTVIN 669
            ..|..:.:...|:.|.:::.||:.|.|.|.:||: |..::.:|...:.|...|......:..:..
 Frog   623 YCGKGEDLCHNDSYVTIQNSELMCGSLDKGTLGSGSKNNIFYILLRDWGQVEAADAMSRLARLAP 687

  Fly   670 NWLLFEGHSIGIGDTIADPQTYNEIQQAIKKAKDDVINV--------IQKAHNMELEPTPGNTLR 726
            .:|...|.||||||....        |.:.|||.|:::.        |:..:..:|:|.||.:..
 Frog   688 VFLSNRGFSIGIGDVTPG--------QGLLKAKQDLLDAGYKKCDEYIEALNTGKLQPQPGCSAE 744

  Fly   727 QTFENKVNRILNDARDKTGGSAKKSLTEYNNLKAMVVSGSKGSNINISQVIACVGQQNVEGKRIP 791
            :|.|..:.|.|:..||..|.:..:.|.:.|:...|.:.|||||.|||||:|||||||.:.|.|:|
 Frog   745 ETLEALILRELSVIRDHAGSACLRELDKSNSPLIMALCGSKGSFINISQMIACVGQQAISGSRVP 809

  Fly   792 YGFRKRTLPHFIKDDYGPESRGFVENSYLAGLTPSEFYFHAMGGREGLIDTAVKTAETGYIQRRL 856
            .||..|:||||.|....|.::|||.||:.:||||:||:||.|.|||||:|||||||||||:||||
 Frog   810 DGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRL 874

  Fly   857 IKAMESVMVNYDGTVRNSVGQLIQLRYGEDGLCGELVEFQNMPTVKLSNKSFEKRFKFDWSNERL 921
            :|::|.:...||.|||:|.|.:||..||.|||....:|.::.|.          .||      |:
 Frog   875 VKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPL----------EFK------RV 923

  Fly   922 MKKVFTDDVIKEMTDSSEAIQELEAEWDRLVSDRDSLRQIFPNGESKVVLPCNLQ------RMIW 980
            ::.|                                          |.|.||:.:      .:|.
 Frog   924 LENV------------------------------------------KAVYPCSEEPALSKNELIL 946

  Fly   981 NVQKIFHINKRLPTDLSPIRVIKGVKTLLERCVIVTG-NDRISKQ-----ANENATLLFQCLIRS 1039
            ..:.|....:.|....|.::.||         ..||| ::||.|.     .|:|.|...:.|.:.
 Frog   947 TSESIMKKTEFLCCQDSYLQEIK---------KFVTGVSERIKKTRDKYGINDNGTTEPRVLYQL 1002

  Fly  1040 TLCTKYVSEEFRLSTEAFEWLVGEIET---RFQQAQANPGEMVGALAAQSLGEPATQMTLNTFHF 1101
            ...|....|:|             :||   ::.:||..||..||||.|||:|||.|||||.||||
 Frog  1003 DRITPTQLEKF-------------LETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHF 1054

  Fly  1102 AGVSSKNVTLGVPRLKEIINISKKPKAPSLTVFLTGGAARDAEKAKNVLCRLEHTTLRKVTANTA 1166
            |||:|.|:||||||:|||||.||....|.:|..|  ....||:.|:.|..|:|
 Frog  1055 AGVASMNITLGVPRIKEIINASKNISTPIITAHL--DIDDDADFARLVKGRIE------------ 1105

  Fly  1167 IYYDPDPQRTVISEDQEFVNVYYEMPD--FDPTRISPWLLRIELDRKRMTDKKLTMEQIAEKINV 1229
                    :|::.|..|::...: :||  |       .|:::.|:|.|:    |.:|..||.:..
 Frog  1106 --------KTLLGEISEYIEEVF-LPDDCF-------LLVKLSLERIRL----LRLEVNAETVRY 1150

  Fly  1230 GF---------------GEDLNCIFNDDNADKLVLRIRIMNNEENKFQDEDEAVDKMEDDMFLRC 1279
            ..               ||.:.|:...:|:...:..:                :..:::|
 Frog  1151 SICMSKLRVKPGDIAVHGEAVLCVTPRENSKSSMYYV----------------LQSLKED----- 1194

  Fly  1280 IEANMLSDMTLQGIEAIGKVYMHLPQTDSKKRIVITETGEFKAIGEWLLETDGTSMMKVLSERDV 1344
                 |..:.:|||..:.:..:|:.:...|::              :.|..:|.::..|::...|
 Frog  1195 -----LPKVVVQGIPEVARAVIHIDEQSGKEK--------------YKLLVEGDNLRSVMATHGV 1240

  Fly  1345 DPIRTSSNDICEIFQVLGIEAVRKSVEKEMNAVLQFYGLYVNYRHLALLCDVMTAKGHLMAITRH 1409
            ...||:||:..|:.:.|||||.|.::..|:...:..:|:.::.||:.||.|:||.||.::.|||.
 Frog  1241 KGSRTTSNNTYEVEKTLGIEAARSTIINEIQYTMVNHGMSIDRRHVMLLADLMTYKGEVLGITRF 1305

  Fly  1410 GINRQDTGALMRCSFEETVDVLMDAAAHAETDPMRGVSENIIMGQLPKMGTGCFDLLLDAEK 1471
            |:.:.....||..|||:|.|.|.|||...:.|.:.||||.||||....:|||.|.||..|:|
 Frog  1306 GLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADK 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2A	NP_511124.1	RNAP_II_RPB1_N	15..868	CDD:259848	334/917 (36%)
		RNA_pol_Rpb1_6	890..1071	CDD:461511	31/195 (16%)
		RNAP_II_Rpb1_C	1050..1468	CDD:132720	134/437 (31%)
		Herpes_BLLF1	<1498..1862	CDD:282904
		PTZ00449	<1707..1880	CDD:185628
polr3a	NP_001096178.1	RNAP_III_RPC1_N	23..890	CDD:259847	335/913 (37%)
		RNAP_III_Rpc1_C	1020..1359	CDD:132723	128/412 (31%)