DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and Kcnb2

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001091998.1	Gene:	Kcnb2 / 98741	MGIID:	99632	Length:	907	Species:	Mus musculus

Alignment Length:	181	Identity:	49/181 - (27%)
Similarity:	79/181 - (43%)	Gaps:	53/181 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KW---KSALNHIGLLVSLSIYCGV-------GGLIFRHLERPAEVERLSHLKDIVKTHRERFLHT 112
            ||   |..||.|.||..|..|..:       ..|.|:::.|..::.|:..:..|:|..|
Mouse   258 KWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLAR------ 316

  Fly   113 ILNNTEVHNLDELLSFELAK-YEAAVQQAAEGGLLIV---------------ADKDFPEPYERWS 161
              ::|.:.:    |.|.|.: |.       |.||||:               |:||  |...:::
Mouse   317 --HSTGLQS----LGFTLRRSYN-------ELGLLILFLAMGIMIFSSLVFFAEKD--EDATKFT 366

  Fly   162 ILQAVFFSSTV-LTTIGYGNIVPVTTGGRVF----CICFAL-IGIPFTLTV 206
            .:.|.|:.:|: :||:|||:|.|.|..|::.    ||...| |.:|..:.|
Mouse   367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	18/56 (32%)
		Ion_trans	<240..314	CDD:278921
		Ion_trans_2	<266..319	CDD:285168
Kcnb2	NP_001091998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		BTB	37..143	CDD:197585
		BTB_2	37..136	CDD:280393
		Ion_trans	230..428	CDD:278921	49/181 (27%)
		Ion_trans_2	341..422	CDD:285168	22/79 (28%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386		3/4 (75%)
		Kv2channel	471..755	CDD:281514
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..859
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000