Protein Alignment CG43155 and KCNK6

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_004814.1
• Gene: KCNK6 / 9424
• HGNCID: 6281
• Length: 313
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 88/334 - (26%)
• Similarity: 148/334 - (44%)
• Gaps: 72/334 - (21%)

  Fly    67 GLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLHTILNNTEVHNLDELLSFELA 131
            |.|.:.:.|..:|.|:...||.|.|    :.|:..::|.|.:.|.. ........||..:...||
Human     9 GALAAYAAYLVLGALLVARLEGPHE----ARLRAELETLRAQLLQR-SPCVAAPALDAFVERVLA 68

  Fly   132 KYEAAVQQAAEGGLLIVAD----KDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFC 192
                    |...|.:::|:    .:..:|  .|....|:||:||::||:|||...|:|..|:.|.
Human    69 --------AGRLGRVVLANASGSANASDP--AWDFASALFFASTLITTVGYGYTTPLTDAGKAFS 123

  Fly   193 ICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTKPKFTNFIGKTW-----------FYAILAV 246
            |.|||:|:|.|:.::.    ..|..:|:...|:|     .:::...|           ..|:|.|
Human   124 IAFALLGVPTTMLLLT----ASAQRLSLLLTHVP-----LSWLSMRWGWDPRRAACWHLVALLGV 179

  Fly   247 GFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVP-KKPN------YMLLCTLYIL 304
             .:.|.....|.:....|:.|:|.|.||||||:::|||.||.|| :.|.      |.:|.|:|:.
Human   180 -VVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLF 243

  Fly   305 IGLALTSTIIELVRRQYATSWAKLQEL---------------------SGPMAETLRRLGETAGT 348
            :||.....:::..|  :.:....|.||                     .||..|:.::|..::.|
Human   244 LGLVAMVLVLQTFR--HVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHT 306

  Fly   349 GLDYTALQK 357
              ||.::.:
Human   307 --DYASIPR 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	25/74 (34%)
		Ion_trans_2	<267..319	CDD:462301	23/58 (40%)
KCNK6	NP_004814.1	Ion_trans_2	75..146	CDD:462301	25/76 (33%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		3/4 (75%)
		Ion_trans_2	180..256	CDD:462301	26/75 (35%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..313		7/26 (27%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312		1/3 (33%)