Protein Alignment Sk1 and CERK

DIOPT Version :10

• Sequence 1: NP_572717.1
• Gene: Sk1 / 32089
• FlyBaseID: FBgn0030300
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_073603.2
• Gene: CERK / 64781
• HGNCID: 19256
• Length: 537
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 141/584 - (24%)
• Similarity: 218/584 - (37%)
• Gaps: 187/584 - (32%)

  Fly   100 ARGGLNSCRNP----NVPGQEADSEPDSDNSAYLYIYA---------------YLKKEKP----- 140
            ||..|...|:|    ..||.:|.|.|.|:      |.|               :.|.|||
Human    28 ARALLRWWRSPGPGAGAPGADACSVPVSE------IIAVEETDVHGKHQGSGKWQKMEKPYAFTV 86

  Fly   141 --LRRVQTLRILRFRSSNDYGVNLQTAEMWHHTIRKHKRGNGSSSPADCGKQLLILLNPKSGSGK 203
              ::|.:..| .::.....:....|...:|..|:|:... ..:|.|    |.||:.:||..|.|:
Human    87 HCVKRARRHR-WKWAQVTFWCPEEQLCHLWLQTLREMLE-KLTSRP----KHLLVFINPFGGKGQ 145

  Fly   204 GRELFQKQVAPLLTEAEVQYDLQITTHPQYAKEFVRTRRDL-LTRYSGIVVASGDGLFYEVLNGL 267
            |:.:::::||||.|.|.:..|:.:|.|...|||   |..:: :.:|.|||...|||:|.|||:||
Human   146 GKRIYERKVAPLFTLASITTDIIVTEHANQAKE---TLYEINIDKYDGIVCVGGDGMFSEVLHGL 207

  Fly   268 MER--------MDWRRAC---RELPLGIIPCGS---------GNGLAKSVAHHCNEPYEPKPILH 312
            :.|        .:..||.   ..|.:||||.||         |...|::.|.|
Human   208 IGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALH------------ 260

  Fly   313 ATLTCMAGKSTPMDVVRVELATRDKHFVMYSFLSVGWGLIADIDIESERLRSIGAQRFTLWAIKR 377
                .:.|.|..|||..|.   .:...:.||...:|:|...||..:||:.|.:|..|:....:|.
Human   261 ----IVVGDSLAMDVSSVH---HNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKT 318

  Fly   378 LIGLRSYKGRVSYLLGKGKKEPPVEAARELPAESTAAGIRSSLPLNAGEF------HDLPEEEEG 436
            .:....|:|.||:                |||:.|....|...|..||.|      ..|  |||.
Human   319 FLSHHCYEGTVSF----------------LPAQHTVGSPRDRKPCRAGCFVCRQSKQQL--EEEQ 365

  Fly   437 EAVLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSMRSNRSRMSISQRIEAANAEF 501
            :..|.|.:.|:.:           :.|....          |..:..|.:.||.:.|
Human   366 KKALYGLEAAEDV-----------EEWQVVC----------GKFLAINATNMSCACR-------- 401

  Fly   502 AERVPTGTIPPLQMPLLSSDGWICEDGDFVMVHAAYTTHLSSDVFFAPESRLDDGLIYLVIIRRG 566
              |.|.|                                      .:|.:.|.||...|::||:
Human   402 --RSPRG--------------------------------------LSPAAHLGDGSSDLILIRK- 425

  Fly   567 VSRHQLLNFML-NLNAGTHLPIGEDPFIKVVPCRAFR-----IEPSSSDGILVVDGERVEYGPI 624
            .||...|.|:: :.|.....   :..|::|...:.|:     :|...||   :.:|.:..:|.|
Human   426 CSRFNFLRFLIRHTNQQDQF---DFTFVEVYRVKKFQFTSKHMEDEDSD---LKEGGKKRFGHI 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	114/465 (25%)
CERK	NP_073603.2	Required for binding to sulfatide and phosphoinositides. /evidence=ECO:0000269|PubMed:19168031	1..125		23/104 (22%)
		Essential for enzyme activity. /evidence=ECO:0000269|PubMed:16269826	1..115		20/93 (22%)
		DAGK_cat	55..528	CDD:445337	131/557 (24%)