Protein Alignment: Sk1 and Cerk

• Sequence 1: NP_572717.1
• Gene: Sk1
• FlyBaseID: FBgn0030300
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_663450.3
• Gene: Cerk
• MGIID: 2386052
• Length: 531
• Species: Mus musculus
• Alignment Length: 581
• Identity: 139/582 (24%)
• Similarity: 216/582 (37%)
• Gaps: 205/582 (35%)

  Fly   110 PNVPGQEADS---------EPDSDNSAYLYIYAYLKKEKP----LRRVQTLRILRFRSS--NDYG 159
            |:.||.:|.|         |...|...:.....:.|.|.|    :.||:.:|..|::.:  ..:.
Mouse    42 PSAPGADARSVLVSEIIAVEEKDDCEKHASSGRWHKMENPFAFTVHRVKRVRHHRWKWARVTFWS 106

  Fly   160 VNLQTAEMWHHTIRKHKRGNG-----SSSPADCGKQLLILLNPKSGSGKGRELFQKQVAPLLTEA 219
            .:.|...:|..|:|      |     :|.|    |.||:.:||..|.|:|:.:::|.||||.|.|
Mouse   107 ADEQLCHLWLQTLR------GLLESLTSRP----KHLLVFINPFGGKGQGKRIYEKTVAPLFTLA 161

  Fly   220 EVQYDLQITTHPQYAKEFVRTRRDLLT-RYSGIVVASGDGLFYEVLNGLMERM--------DWRR 275
            .:..::.||.|...|||   |..::.| .|.|||...|||:|.|||:|::.|.        :..|
Mouse   162 SITTEIIITEHANQAKE---TLYEINTDSYDGIVCVGGDGMFSEVLHGVIGRTQQSAGIDPNHPR 223

  Fly   276 AC---RELPLGIIPCGS---------GNGLAKSVAHHCNEPYEPKPILHATLTCMAGKSTPMDVV 328
            |.   ..|.:||||.||         |...|::.|.|                .:.|.|..:||.
Mouse   224 AVLVPSTLRIGIIPAGSTDCVCYSTVGTNDAETSALH----------------IIIGDSLAIDVS 272

  Fly   329 RVELATRDKHF----VMYSFLSVGWGLIADIDIESERLRSIGAQRFTLWAIKRLIGLRSYKGRVS 389
            .|       |:    :.||...:|:|...|:..:||:.|.:|..|:....:|..:..:.|:|.:|
Mouse   273 SV-------HYHNTLLRYSVSLLGYGFYGDLIKDSEKKRWMGLVRYDFSGLKTFLSHQYYEGTLS 330

  Fly   390 YLLGKGKKEPPVEAARELPAESTAAGIRSSLPLNAGEF------HDLPEEEEGEAVLDGEQFADA 448
            :                |||:.|....|.:.|..||.|      ..|.|||
Mouse   331 F----------------LPAQHTVGSPRDNKPCRAGCFVCRQSKQQLEEEE-------------- 365

  Fly   449 ISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSMRSNRSRMSISQRIEAANAEFAERVPTGTIPPL 513
                                 :.|.|.|                    .|||..|.
Mouse   366 ---------------------KKALYGL--------------------ENAEEMEE--------- 380

  Fly   514 QMPLLSSDGWICEDGDFVMVHAAYTTHLS-----SDVFFAPESRLDDGLIYLVIIRRGVSRHQLL 573
                     |....|.|:.::|   |::|     |....:|.:.|.||...|::||: .||...|
Mouse   381 ---------WQVTCGKFLAINA---TNMSCACPRSPGGLSPFAHLGDGSSDLILIRK-CSRFNFL 432

  Fly   574 NFML-NLNAGTHLPIGED----PFIKVVPCRAF-----RIEPSSSDGILVVDGERVEYGPI 624
            .|:: :.|.       ||    .|::|...:.|     .:|...:|.   .:.|:.::|.|
Mouse   433 RFLIRHTNQ-------EDQFDFTFVEVYRVKKFHFTSKHVEDEDNDS---KEQEKQKFGKI 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	116/479 (24%)
		DAGK_cat	191..330	CDD:279163	52/160 (33%)
Cerk	NP_663450.3	Required for binding to sulfatide and phosphoinositides. {ECO:0000250}	1..125		19/89 (21%)
		PLN02204	84..528	CDD:215126	129/540 (24%)
		Substrate binding. {ECO:0000250}	195..198		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C108699986
eggNOG	1	0.900				E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D681139at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R653
TreeFam	0	0.000	Not matched by this tool.
	4	3.870