Protein Alignment dsh and Dvl3

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_063126544.1
• Gene: Dvl3 / 303811
• RGDID: 1308834
• Length: 718
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 303/671 - (45%)
• Similarity: 392/671 - (58%)
• Gaps: 135/671 - (20%)

  Fly    10 ETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDST 74
            |||:|||:|.:.||||||:|:|:.:|||.|||.||  |..:||:||||||.|||||||||:||:.
  Rat     3 ETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVL--QRPSYKFFFKSMDDDFGVVKEEISDDNA 65

  Fly    75 ILPCFNGRVVSWLVSADGTNQ------SDNCSELPTSECELG--------------MGLTNRKLQ 119
            .|||||||||||||||:|::.      :||.||||.|....|              .|.:...|.
  Rat    66 KLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLD 130

  Fly   120 QQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASV 184
            ...:.......|:::..::...:...::......:::::                 |..|.|:|.
  Rat   131 NDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRRE-----------------PGGYDSSST 178

  Fly   185 L-SSDLDSTSLFGTESELTLDR--DMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTM 246
            | ||:|::||.|.::.:.:..|  ..|:.||..||..|.|.:|||::...:.|:||:||||||||
  Rat   179 LMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTM 243

  Fly   247 SLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFE 311
            |||||||::|||..||||||||||||..||||||:||||||||||.|||||||||:||||::|||
  Rat   244 SLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFE 308

  Fly   312 NMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALT---- 372
            ||:||:|||||||:|.|||||.|.|||||||:|:|.||:||:||:|||||.|||:||.|:|
  Rat   309 NMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFP 373

  Fly   373 -------------SHDSIIADIAEPIKERLD------QNNLEEIVKAMTKPDSGLEIRDRMWLKI 418
                         :..||.:.|  |..||||      .:::..|||||..|:||||:||||||||
  Rat   374 AYGMSPSLSTITSTSSSITSSI--PDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKI 436

  Fly   419 TIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNE--ERN 481
            ||||||||:|.|:|:..|||...||||||:..|.:|::.:|:|||||:||||||||:..:  ...
  Rat   437 TIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNM 501

  Fly   482 PNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNP-----PIYMPYS-----ATYNPSH 536
            .||    .||.|.     |....|..||      :.|||:|     |:..||.     ..|||..
  Rat   502 ANL----SLHDHD-----GSSGASDQDT------LAPLPHPGAAPWPMAFPYQYPPPPHPYNPHP 551

  Fly   537 GYQPIQY----GIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSN 597
            |:..:.|    |.|....|.||.||                              |||: |||..
  Rat   552 GFPELGYSYAGGSASSQHSEGSRSS------------------------------GSNR-SGSDR 585

  Fly   598 R------GGGGGGGGGGNNTN 612
            |      .|....||.|:.::
  Rat   586 RKEKDPKAGDSKSGGSGSESD 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	57/80 (71%)
		Dishevelled	<174..248	CDD:460544	33/76 (43%)
		PDZ_Dishevelled-like	252..338	CDD:467201	68/85 (80%)
		DEP_dishevelled	395..478	CDD:239885	54/82 (66%)
Dvl3	XP_063126544.1	None