Protein Alignment dsh and dsh-2

DIOPT Version :10

• Sequence 1: NP_511118.2
• Gene: dsh / 32078
• FlyBaseID: FBgn0000499
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: NP_494937.4
• Gene: dsh-2 / 266854
• WormBaseID: WBGene00001102
• Length: 759
• Species: Caenorhabditis elegans
• Alignment Length: 674
• Identity: 197/674 - (29%)
• Similarity: 306/674 - (45%)
• Gaps: 149/674 - (22%)

  Fly    11 TKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGV-VKEEIADDS- 73
            |||..|:||:..||:|::.:|...:||||.|..|  ...|:||:..::|.|.|: ||.|:.|||
 Worm   104 TKVYCHLDDQEHPYMVEVHVPPDCITLRDVKRKL--MRTNFKYYCIALDPDTGLEVKAEVRDDSR 166

  Fly    74 TILPCFNGRVVSWLVSADGTNQSD----------------------------------------- 97
            .:.|..|||...:|::.:|:..||
 Worm   167 RLYPLKNGRFELYLLTVEGSVHSDTSSGRHRRKQDGSSKGSSGSREYLRAAHHYDNPTPFSDDES 231

  Fly    98 NCSELPTSECELGMGLTNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLH 162
            ..|.|||..         :|.....::|..|..::...|.:...:.....|.            |
 Worm   232 QASSLPTYV---------KKAHAYNRKHAPQAYERHLPHMKHNNRHNHHRQN------------H 275

  Fly   163 HQKMMGNPLLQPPPLTYQSASVLSSDLDSTSLFGTESELTLDRDMTDYSSV---QRLQVRKKPQR 224
            :::...:...:.........:....|.|.:.        :::.|:|..|.|   |:.:.::|..|
 Worm   276 YEESTFDVTTESDDHYRDGVTYYDEDEDDSR--------SINTDLTSVSQVHLKQKWRQQQKEMR 332

  Fly   225 RK-KRAPSMS-RTSSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKG 287
            .| ||.||:| .:||:||||:|:|.|.:|||.:|:|.:. ||::..|.:|..||.|:|||.|...
 Worm   333 NKWKRMPSISTASSSFSSITESSMGLEVITVRLNLETIP-LGMTPSGHTNARGDAGLYVGDIQDR 396

  Fly   288 GAVALDGRIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPR 352
            |||||||||:.||||:.:|:::..|.:|.|||::|||.||:. .:.|.:||..||....:...||
 Worm   397 GAVALDGRIDIGDMIVGINEISLGNYSNKEAVQLLREAVQRQ-YLTLTIAKTGDPKQNAFPRNPR 460

  Fly   353 TEPVRPIDPGAWVAH-TQALTSHDSIIADIAE-PIKERLDQN---------------------NL 394
            .||:|||||..||.| |.|:.:..||..:.:. ||.:....|                     :.
 Worm   461 AEPIRPIDPNEWVKHATNAMKAMPSISEESSSTPIPDDWPTNSSASGTPFGGPPPANCLNVMTDK 525

  Fly   395 EEIVKAMTKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYI 459
            :.:|:.|..|.|||:|:||.|.||.||.:|:|.|.|.|::::|:.::.:::||.....||:..||
 Worm   526 KYVVEVMAAPGSGLDIKDRYWFKIPIPMSFLGTDLVEWLVKHVQGLETKKKAREFAEEMLKLGYI 590

  Fly   460 KHTVNKLTFSEQCYYVVNEERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNPP- 523
            :..|.|.:|:::||||:.:|.......||....::.|..|...|..|:....|.......|.||
 Worm   591 RPGVGKQSFTKECYYVMGDECADYTQLRGPDGGYKYPQSHASSASGHSSNNLIFPPSMYPPQPPT 655

  Fly   524 ---------IYMPYSATYNPSHGY-----QPIQYGIAERHISSGSSSSDVLTSKDISASQSDITS 574
                     :.:|.|.|    .||     .|..:|.|        |.:|...::|...||:
 Worm   656 AGAVHHRNSVILPSSMT----GGYASLPASPFPHGKA--------SVNDCRRTRDDQRSQA---- 704

  Fly   575 VIHQANQLTIAAHGSNKSSGSSNR 598
                          |..|.|||.|
 Worm   705 --------------SGSSRGSSRR 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dsh	NP_511118.2	DAX	8..91	CDD:197474	33/81 (41%)
		Dishevelled	<174..248	CDD:460544	23/78 (29%)
		PDZ_Dishevelled-like	252..338	CDD:467201	40/85 (47%)
		DEP_dishevelled	395..478	CDD:239885	33/82 (40%)
dsh-2	NP_494937.4	DAX	101..184	CDD:197474	33/81 (41%)
		PDZ_Dishevelled-like	362..446	CDD:467201	40/85 (47%)
		DEP_dishevelled	528..609	CDD:239885	33/80 (41%)