Protein Alignment GCS1 and YMR196W

DIOPT Version :10

• Sequence 1: NP_572707.4
• Gene: GCS1 / 32073
• FlyBaseID: FBgn0030289
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_013923.1
• Gene: YMR196W / 855236
• SGDID: S000004809
• Length: 1088
• Species: Saccharomyces cerevisiae
• Alignment Length: 1022
• Identity: 201/1022 - (19%)
• Similarity: 321/1022 - (31%)
• Gaps: 387/1022 - (37%)

  Fly    47 FSLSSNLILDKWKTMIGCVCLAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPL 111
            |.:|.|..|         ||:.:|.:.|....|:.|:            .||..|....|.....
Yeast    75 FGVSDNKQL---------VCMNVALWNGKDERLKERL------------FGLTGPQGNHGEDVKE 118

  Fly   112 TYFGMKTRDPHSLVMGLMWYTPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDL-- 174
            .||.:.....||.:..|..|......|..:.::...|:|          ::.:.|.|.:|..|
Yeast   119 LYFYLDNTPTHSYMKALYKYPFKKAFPYKELVQKNGERG----------YEDKEFEVYDIDGLYR 173

  Fly   175 ----------------------PFELKTSFVKYPEGKQYGGDW--TARISVRNT-----TRAWDK 210
                                  |.||......:...|...|:.  ..::..|||     ||..||
Yeast   174 DSETGDNPYFDVFFEMAKDDENPSELNFRLTIHNRSKIDSGELYIAPQLFFRNTWAFDGTRTKDK 238

  Fly   211 SI--------SLIWYVALDERTNGHIKYVSDDKSPEPG--------------------------- 240
            .:        :||   .:..:..|:.:.|.   .|.||
Yeast   239 PLLERDAEAANLI---NMTHKKYGNCQMVF---QPSPGGFSSGTNEEEEDKEVEDIDPLLLFTDN 297

  Fly   241 ------VYGEAQGLGEF---QVRFHAVKGKILHKSYLSTVAPSLAKLKDTLFSHFRAFADKRGNR 296
                  ::.|.:...|:   ....:.|:||      ...|.|.....|.....||:...
Yeast   298 ESNLVKLFNEEKNPSEYTKDAFEEYLVQGK------TDAVNPENKGTKACAVYHFKNIP------ 350

  Fly   297 FIGLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSL 361
                |||.|:.....:::|:.:....|..|.||                            :|
Yeast   351 ----PGEYVTVRYKFTNDPKNSIFKAQNLAVVD----------------------------ED-- 381

  Fly   362 QAKIAQFEQRFEDR--------FQLKQKGHSPEEVRFARNALSNLLGGIGYFY---------GSS 409
                 :|:..|::|        :::.....|.|.....|.|.|.|| ....||         |.:
Yeast   382 -----EFDLIFDNREEEADNFYWRITPLPISDELRNLQRQAFSGLL-WTKQFYNFTYDAWYNGDA 440

  Fly   410 RVQSVYTKNPVP--------YWKAPLY----TAVPSRSFFPRGFLWDEGFHGLLISAWDIDI--- 459
            .|:    ..|.|        .|| .||    .::|.:..:|....||..||.:.::..|.:.
Yeast   441 NVK----PRPPPNRANGRNKNWK-HLYIEDILSMPDKWEYPFFASWDTAFHCIPLAMIDPEFAKR 500

  Fly   460 ELDIIC-HWFDLLNVEGWIPREQILGVEALAKVPEEFVTQRNSN-ANPPTFFLTLKKLLTSHRAE 522
            :||::. .|:  ::..|.||                 ..:.|.| .|||.....:.::....|..
Yeast   501 QLDLLTREWY--MHPNGQIP-----------------AYEWNFNDVNPPVHAWAVYRVFKIERNM 546

  Fly   523 LSQNGRLATLERLYPRVQAWFNWFNTTQRGEVLGTYLWRGRNATTTRELNPKSLSSGLDD---YP 584
            .::..| ..|||::.::...|.|:  ..|.:..|..::.|.             ..|||:   :.
Yeast   547 YNREDR-TFLERVFQKLLLNFTWW--VNRKDTEGKNVFEGG-------------FLGLDNIGVFN 595

  Fly   585 RASH-PTDKE-RHLDLRCWIALAAGVMAELSTLLGKDDAKYYETAS----------------YLT 631
            |:.. ||... ...|...|:|..:..|..::..|.|::..|.:.||                |.|
Yeast   596 RSEPLPTGGTLEQADSTGWMAFFSLQMLNIALELAKENPVYEDIASKFFEHFILISDSMSFEYAT 660

  Fly   632 D--------NVRLNRLHLAPYSEQYAD---WGLHTDQVKLKRPPSMAPQQQQRHHHQHYQLPEMQ 685
            |        .::.|..:.|  .:.|.|   ||.|                       ..||| ::
Yeast   661 DITGEKCKEVIKQNLWNEA--DKFYYDAISWGDH-----------------------KVQLP-IR 699

  Fly   686 RVTGELPTY-----------QF------VDSAFGYVSLFP------------------LLLEQLD 715
            .:.|.:|.|           ||      ||   .:|:..|                  |||..:.
Yeast   700 SLVGLIPLYASMTLEPSIIKQFRGFKKRVD---WFVNNRPEIFDRNIASMSKKGVGERLLLSLVT 761

  Fly   716 HDSPYLTKLLNDLRDPEQLWTNYGLRSLSK---RSPLYMQRN-TEHDPPY--------------- 761
            .:.  ||.:|:.|.|..:..:.||:|||||   :.|..|..| .|:...|
Yeast   762 KER--LTAILSRLLDETEFLSPYGIRSLSKYHEKHPFEMNVNGVEYMVKYLPGESDSGMFGGNSN 824

  Fly   762 WRGPIWININYLAAKALH----HYG---KIDGP-------NAALA------RQIYAELRDNLVGN 806
            ||||||...::|..:||.    :||   |::.|       |.|..      |.|:..:.|.....
Yeast   825 WRGPIWFPTSFLIMEALQRFYLYYGSDFKVECPVGSGDYLNLAEVAEELGYRMIHLFVPDENGER 889

  Fly   807 ILRQYKRSGYL------------WEQYDDTSGEGKGCNPFTGWTATV 841
            .:.....|.:|            :|.:|..:|.|.|.:...||||.|
Yeast   890 AIHYGDHSKFLSSDPYFRDYVPFFEYFDGDTGRGLGASHQCGWTALV 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_572707.4	Glyco_hydro_63N	104..>256	CDD:465316	35/226 (15%)
		Glyco_hydro_63	352..847	CDD:397353	136/642 (21%)
YMR196W	NP_013923.1	GDB1	475..934	CDD:442634	111/524 (21%)