DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and Mogs

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_113937.2	Gene:	Mogs / 78947	RGDID:	69240	Length:	834	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	362/887 - (40%)
Similarity:	477/887 - (53%)	Gaps:	113/887 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARNTGSSSGSTPAASSSGSSAAAAAAAAAAAAAASNAKQKQRSPRFSLSSNLILDKWKTMIGCVC 66
            ||..|...|.  |..:.||:..||.|....|.|            |.||...:| .|..:...:.
  Rat    22 ARGAGRRDGR--AGGARGSAGGAALAVVVLALA------------FGLSGRWVL-AWLRVRRALT 71

  Fly    67 LAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPLTYFGMKTRDPHSLVMGLMWY 131
            |..|.           ...|.|.....|     .|:.:||:|||..|||||||.|..|:.||||.
  Rat    72 LHPAP-----------SALPPDSSSPAV-----APELFWGTYRPHVYFGMKTRSPKPLLTGLMWA 120

  Fly   132 -------TPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDLPFELKTSFVKYPEGK 189
                   ||..|       ||.|||||.:..|||..|||.|||.|.|.|....|.|.||| ..|.
  Rat   121 QQGATPGTPPKL-------RHTCEQGDGVGPYGWEFHDGLSFGRQHIYDGALRLTTEFVK-RSGG 177

  Fly   190 QYGGDWTARISVRNTTRAWDK--SISLIWYVALDER--------TNGHIKYVSDDKSPEPGVYGE 244
            .:||||:.|::|.........  .:||.:||..|.:        ..|.:|::|          |.
  Rat   178 HHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLPEVGAKGQLKFIS----------GH 232

  Fly   245 AQGLGEFQVRF--HAVKGKIL--HKSY--LSTVAPSLAKLKDTLFSHFRAFADKR-----GNRFI 298
            ...||:|::..  ....|..:  |.||  ..:..|.|..|.|.:.||..::...|     ..|::
  Rat   233 TSELGDFRLTLLPPTTPGDTVPKHGSYNVFWSSNPGLPLLTDMVKSHLNSWFHHRPPGASPERYL 297

  Fly   299 GLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSLQA 363
            ||||.:..:...||.  :..|:..|:|.:..|:::..::|.|..:..:...:...|.....:|::
  Rat   298 GLPGSLKWEERGPSG--QGQFLVQQVTLKAPFSVEFVFESGSARTGRDQASEQLVGGQLTRALES 360

  Fly   364 KIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYGSSRV-------QSVYTKNPVP 421
            ..|.|::|||..||||:||.||||....:.|||.||||||||||...|       .|....:|..
  Rat   361 HAAAFKERFERTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTGMEGSEQKMDPSL 425

  Fly   422 YWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQILGVE 486
            :...||::.||||||||||||||||||.|::..||..:..:.:.||..|||.:|||.||||||.|
  Rat   426 FPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDE 490

  Fly   487 ALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLERLYPRVQAWFNWFNTTQR 551
            |.|:||.||:.||.::|||||..|.:..:|.....|     .||.|.|.:||:.|||:|.:.:|.
  Rat   491 ARARVPPEFLVQRAAHANPPTLLLPVIHMLEGRAPE-----DLAFLRRAFPRLHAWFSWLHQSQA 550

  Fly   552 GEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMAELSTLL 616
            |.|..:|.||||:......||||:|.||||||||||||:..|||||||||:.|.|.|:::|:..|
  Rat   551 GPVPLSYRWRGRDLALPTLLNPKTLPSGLDDYPRASHPSAAERHLDLRCWVTLGARVLSQLAEEL 615

  Fly   617 GKDD--AKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLK-RPPSMAPQQQQRHHHQH 678
            |:.:  |:....|:.|.....|:.||.||....:||:|.||..|:|| |||.
  Rat   616 GETEAAAELGPLAASLEAAGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQ------------- 667

  Fly   679 YQLPEMQRVTGE-LPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGLRS 742
                .:.||.|. .|..|:|| |.||||||||||:.|:..||.|..||:.|.|...||:.:||||
  Rat   668 ----GLVRVVGRPPPRLQYVD-ALGYVSLFPLLLQLLEPSSPRLGPLLDVLADSRHLWSPFGLRS 727

  Fly   743 LSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVGNI 807
            ||..|..|.|||||||||||||.:|:||||||..||||||:::||:...|.::|.|||.|:|.|:
  Rat   728 LSASSLFYKQRNTEHDPPYWRGAVWLNINYLALGALHHYGRVEGPHKVQAAKLYRELRANVVSNV 792

  Fly   808 LRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            .:||:.:|:|||||.|..|.|.||.||.|||:.|:|:|||::
  Rat   793 RQQYQATGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	72/201 (36%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	249/505 (49%)
Mogs	NP_113937.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		5/16 (31%)
		Endoplasmic reticulum targeting	3..9
		Required for endoplasmic reticulum targeting. /evidence=ECO:0000250	74..136		28/84 (33%)
		Glyco_hydro_63N	92..>260	CDD:407154	67/185 (36%)
		Glyco_hydro_63	349..832	CDD:397353	249/505 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352388
Domainoid	1	1.000	473	1.000	Domainoid score	I420
eggNOG	1	0.900	-	-		E1_KOG2161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4593
Inparanoid	1	1.050	592	1.000	Inparanoid score	I943
OMA	1	1.010	-	-		QHG53903
OrthoDB	1	1.010	-	-		D162821at33208
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		otm45234
orthoMCL	1	0.900	-	-		OOG6_103455
Panther	1	1.100	-	-	O	PTHR10412
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770