Protein Alignment GCS1 and Mogs

DIOPT Version :10

• Sequence 1: NP_572707.4
• Gene: GCS1 / 32073
• FlyBaseID: FBgn0030289
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_113937.2
• Gene: Mogs / 78947
• RGDID: 69240
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 887
• Identity: 362/887 - (40%)
• Similarity: 477/887 - (53%)
• Gaps: 113/887 - (12%)

  Fly     2 ARNTGSSSGSTPAASSSGSSAAAAAAAAAAAAAASNAKQKQRSPRFSLSSNLILDKWKTMIGCVC 66
            ||..|...|.  |..:.||:..||.|....|.|            |.||...:| .|..:...:.
  Rat    22 ARGAGRRDGR--AGGARGSAGGAALAVVVLALA------------FGLSGRWVL-AWLRVRRALT 71

  Fly    67 LAIASYFGYLGYLETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPLTYFGMKTRDPHSLVMGLMWY 131
            |..|.           ...|.|.....|     .|:.:||:|||..|||||||.|..|:.||||.
  Rat    72 LHPAP-----------SALPPDSSSPAV-----APELFWGTYRPHVYFGMKTRSPKPLLTGLMWA 120

  Fly   132 -------TPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDLPFELKTSFVKYPEGK 189
                   ||..|       ||.|||||.:..|||..|||.|||.|.|.|....|.|.||| ..|.
  Rat   121 QQGATPGTPPKL-------RHTCEQGDGVGPYGWEFHDGLSFGRQHIYDGALRLTTEFVK-RSGG 177

  Fly   190 QYGGDWTARISVRNTTRAWDK--SISLIWYVALDER--------TNGHIKYVSDDKSPEPGVYGE 244
            .:||||:.|::|.........  .:||.:||..|.:        ..|.:|::|          |.
  Rat   178 HHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLPEVGAKGQLKFIS----------GH 232

  Fly   245 AQGLGEFQVRF--HAVKGKIL--HKSY--LSTVAPSLAKLKDTLFSHFRAFADKR-----GNRFI 298
            ...||:|::..  ....|..:  |.||  ..:..|.|..|.|.:.||..::...|     ..|::
  Rat   233 TSELGDFRLTLLPPTTPGDTVPKHGSYNVFWSSNPGLPLLTDMVKSHLNSWFHHRPPGASPERYL 297

  Fly   299 GLPGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQSTSGFSLGESIPKPPTGRAYQDSLQA 363
            ||||.:..:...||.  :..|:..|:|.:..|:::..::|.|..:..:...:...|.....:|::
  Rat   298 GLPGSLKWEERGPSG--QGQFLVQQVTLKAPFSVEFVFESGSARTGRDQASEQLVGGQLTRALES 360

  Fly   364 KIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIGYFYGSSRV-------QSVYTKNPVP 421
            ..|.|::|||..||||:||.||||....:.|||.||||||||||...|       .|....:|..
  Rat   361 HAAAFKERFERTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTGMEGSEQKMDPSL 425

  Fly   422 YWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWFDLLNVEGWIPREQILGVE 486
            :...||::.||||||||||||||||||.|::..||..:..:.:.||..|||.:|||.||||||.|
  Rat   426 FPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDE 490

  Fly   487 ALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLERLYPRVQAWFNWFNTTQR 551
            |.|:||.||:.||.::|||||..|.:..:|.....|     .||.|.|.:||:.|||:|.:.:|.
  Rat   491 ARARVPPEFLVQRAAHANPPTLLLPVIHMLEGRAPE-----DLAFLRRAFPRLHAWFSWLHQSQA 550

  Fly   552 GEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDLRCWIALAAGVMAELSTLL 616
            |.|..:|.||||:......||||:|.||||||||||||:..|||||||||:.|.|.|:::|:..|
  Rat   551 GPVPLSYRWRGRDLALPTLLNPKTLPSGLDDYPRASHPSAAERHLDLRCWVTLGARVLSQLAEEL 615

  Fly   617 GKDD--AKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLK-RPPSMAPQQQQRHHHQH 678
            |:.:  |:....|:.|.....|:.||.||....:||:|.||..|:|| |||.
  Rat   616 GETEAAAELGPLAASLEAAGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQ------------- 667

  Fly   679 YQLPEMQRVTGE-LPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLNDLRDPEQLWTNYGLRS 742
                .:.||.|. .|..|:|| |.||||||||||:.|:..||.|..||:.|.|...||:.:||||
  Rat   668 ----GLVRVVGRPPPRLQYVD-ALGYVSLFPLLLQLLEPSSPRLGPLLDVLADSRHLWSPFGLRS 727

  Fly   743 LSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAALARQIYAELRDNLVGNI 807
            ||..|..|.|||||||||||||.:|:||||||..||||||:::||:...|.::|.|||.|:|.|:
  Rat   728 LSASSLFYKQRNTEHDPPYWRGAVWLNINYLALGALHHYGRVEGPHKVQAAKLYRELRANVVSNV 792

  Fly   808 LRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            .:||:.:|:|||||.|..|.|.||.||.|||:.|:|:|||::
  Rat   793 RQQYQATGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_572707.4	Glyco_hydro_63N	104..>256	CDD:465316	64/170 (38%)
		Glyco_hydro_63	352..847	CDD:397353	249/505 (49%)
Mogs	NP_113937.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		5/16 (31%)
		Endoplasmic reticulum targeting	3..9
		Required for endoplasmic reticulum targeting. /evidence=ECO:0000250	74..136		28/84 (33%)
		Glyco_hydro_63N	92..>260	CDD:465316	67/185 (36%)
		Glyco_hydro_63	349..832	CDD:397353	249/505 (49%)