DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GCS1 and mogs

DIOPT Version :9

Sequence 1:	NP_001245621.1	Gene:	GCS1 / 32073	FlyBaseID:	FBgn0030289	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_031751080.1	Gene:	mogs / 619362	XenbaseID:	XB-GENE-5911793	Length:	822	Species:	Xenopus tropicalis

Alignment Length:	838	Identity:	376/838 - (44%)
Similarity:	507/838 - (60%)	Gaps:	98/838 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 MIGCVCLAI-ASYFGYLGYL-------------ETRVNTPFDHQKMVVHAGLEQPDRYWGSYRPL 111
            ::..|..|| .|.|.|.||:             ..||..|......:      .|:.:||||||.
Frog    34 LVALVSCAIGVSAFAYSGYMRWSLALRVLTLHPSPRVWPPNSSSSAL------SPNMFWGSYRPQ 92

  Fly   112 TYFGMKTRDPHSLVMGLMWYTPSNLGPGGQGIRHWCEQGDKLDSYGWTHHDGRSFGVQEIQDLPF 176
            .|||||||.|||:|.||||.:.:    |...:||.|||||.|..|||..|||.:||||||.|..|
Frog    93 LYFGMKTRSPHSVVTGLMWLSQA----GAPSLRHTCEQGDGLARYGWLLHDGENFGVQEITDRGF 153

  Fly   177 ELKTSFVKYPEGKQYGGDWTARISVR-NTTRAWDKSISLIWYVALDER--------TNGHIKYVS 232
            .|:|.|||.| |..:||||:.||... ..:.:..:.:||::|||.|.:        ...|:.:|:
Frog   154 TLRTEFVKRP-GGDHGGDWSWRIRASPQASSSPGQILSLMFYVATDGQGTLTPHVAGRRHLTHVT 217

  Fly   233 DDKSPEPGVYGEAQGLGEFQVRFHAVKGKILHKS--YLSTVAPSLAKLKDTL-------FSHFRA 288
                      ||::.||.|.:||...:|...|.|  ||||..|.|..|.|.:       |:|...
Frog   218 ----------GESEELGPFTLRFLTAEGGDGHVSYNYLSTTCPGLHTLTDVVRTSLRDHFTHPTE 272

  Fly   289 FADKRGN--RFIGL----PGEIVSQNGLPSSNPEPNFIAIQITAEVDFTLDITYQS--------- 338
            ....|||  |:.||    |..:  ..|.|:..|....:..|:|.::.|..::.::|
Frog   273 SGGSRGNKRRYFGLDSYHPPPL--PPGTPAPPPHTQLVVHQLTLQLPFQAEVLFESGSFQQRPGQ 335

  Fly   339 TSGFSLGESIPKPPTGRAYQDSLQAKIAQFEQRFEDRFQLKQKGHSPEEVRFARNALSNLLGGIG 403
            .||.|||..:.:..|             ..|.||:..|:|::||.:|::|.||:.||||:|||:|
Frog   336 LSGVSLGTELDRHKT-------------NMENRFQSIFRLEEKGFTPDQVAFAQAALSNMLGGMG 387

  Fly   404 YFYGSSRVQSVYTKNPVPYWKAPLYTAVPSRSFFPRGFLWDEGFHGLLISAWDIDIELDIICHWF 468
            ||||||.|:|.:...||.|..||||||||||||||||||||||||.|||..|:..:....:.||.
Frog   388 YFYGSSVVKSPHNAEPVLYPAAPLYTAVPSRSFFPRGFLWDEGFHLLLIGRWNPSLAWQSLGHWL 452

  Fly   469 DLLNVEGWIPREQILGVEALAKVPEEFVTQRNSNANPPTFFLTLKKLLTSHRAELSQNGRLATLE 533
            ||:|.:||||||||||.||.:|||:|||.|::.||||||.||.|::||.:...:       ..|.
Frog   453 DLMNADGWIPREQILGSEARSKVPDEFVIQKSENANPPTLFLALRQLLANTEGD-------EALR 510

  Fly   534 RLYPRVQAWFNWFNTTQRGEVLGTYLWRGRNATTTRELNPKSLSSGLDDYPRASHPTDKERHLDL 598
            |.:||:|.|::|:|:||.|.:..||.||||:....|.||||:|:||||||||||||:::|||:||
Frog   511 RAWPRLQTWYDWYNSTQAGLLPHTYRWRGRDQDPLRFLNPKTLTSGLDDYPRASHPSEEERHVDL 575

  Fly   599 RCWIALAAGVMAELSTLLGKDDAKYYETASYLTDNVRLNRLHLAPYSEQYADWGLHTDQVKLK-- 661
            |||:|||:.|||:::..|.:|..:|....:.||||..|:..|.:.....|||:|.||....|:
Frog   576 RCWMALASQVMADIAERLEEDGGRYRHDHNILTDNALLDHHHWSERLGAYADYGNHTQNTALEWV 640

  Fly   662 RPPSMAPQQQQRHHHQHYQLPEMQRVTGELPTYQFVDSAFGYVSLFPLLLEQLDHDSPYLTKLLN 726
            ||.: ||.|..|    ....|::.||..:.|..|:| .|.|||||||.||:.||..:|:|.:||:
Frog   641 RPRA-APGQDPR----SVPPPQLIRVVRKPPRLQYV-GALGYVSLFPFLLQVLDPSAPHLGRLLD 699

  Fly   727 DLRDPEQLWTNYGLRSLSKRSPLYMQRNTEHDPPYWRGPIWININYLAAKALHHYGKIDGPNAAL 791
            .:||.::|||.||:|||||.||||:|||||||.||||||||||:|||..:||:.|.:::||:...
Frog   700 LIRDADKLWTPYGIRSLSKGSPLYLQRNTEHDAPYWRGPIWINMNYLTVRALYLYSQMEGPHRDR 764

  Fly   792 ARQIYAELRDNLVGNILRQYKRSGYLWEQYDDTSGEGKGCNPFTGWTATVVLLMAEQF 849
            ...:|.|||.||:.|:.||||.:|:|||||:|.:|:|:||.|||||::.:||:|||::
Frog   765 LVSLYRELRQNLLANLYRQYKNTGFLWEQYNDQTGQGQGCFPFTGWSSLLVLIMAEEY 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GCS1	NP_001245621.1	Glyco_hydro_63N	104..283	CDD:293528	83/196 (42%)
GCS1	NP_001245621.1	Glyco_hydro_63	352..847	CDD:281228	258/496 (52%)
mogs	XP_031751080.1	Glyco_hydro_63N	84..>247	CDD:407154	77/177 (44%)
mogs	XP_031751080.1	Glyco_hydro_63	336..820	CDD:397353	263/509 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	532	1.000	Domainoid score	I287
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	679	1.000	Inparanoid score	I715
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162821at33208
OrthoFinder	1	1.000	-	-		FOG0004064
OrthoInspector	1	1.000	-	-		oto103408
Panther	1	1.100	-	-	LDO	PTHR10412
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160