Protein Alignment CG42249 and SMN1

DIOPT Version :10

• Sequence 1: NP_572684.2
• Gene: CG42249 / 32043
• FlyBaseID: FBgn0259101
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_012072.3
• Gene: SMN1 / 856609
• SGDID: S000001245
• Length: 602
• Species: Saccharomyces cerevisiae
• Alignment Length: 538
• Identity: 109/538 - (20%)
• Similarity: 177/538 - (32%)
• Gaps: 178/538 - (33%)

  Fly    26 AEAADKEGFPVAIIHINDLHARFEATDTSGG-----TCDEGEECIGGYPRTVYTVKRLLQEQAEL 85
            |..|..:..|:..|||.|::. ...|||.|.     :.::.:...|.:...|..::..:..|:.
Yeast    26 AVLAPSQDVPLRDIHIGDINF-IHTTDTHGWLGSHLSQNDYDADWGDFVAFVDILREKILRQSR- 88

  Fly    86 NPIYINAGDSFQGTLWYNIGRWNVT-------QQLLNLLPADVMTLGNHEFDHGVEGVVPFLETV 143
            :.|.|:.||...|.     |..:.|       .::.|::..|::||||||.......::.:..|.
Yeast    89 DVIVIDTGDKRDGN-----GLSDATWPPGLRSSEIFNMMDYDLLTLGNHELYTAESAILEYRGTS 148

  Fly   144 DTNMLVANMDCAHEPTMEGK------YNKSMIIERSGRKIGVIGVILETTYDLAN---------- 192
            .::.......|::...:|..      .||.:..|....|..|:.:....::..||
Yeast   149 QSSKFKDKYVCSNVEFIEDDGTRVPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTPPLE 213

  Fly   193 --TGKVIFRNESDTIREEAQLLKAQGANIIIVVSHCGYDVDQQIAANAGDWIDVIVGSHSHTFLY 255
              |.|..|:|..:|.|||.       .::|||..
Yeast   214 EITQKSWFQNMVETNREEE-------IDLIIVFG------------------------------- 240

  Fly   256 TGDPPGPHTPSGD----------------YPTEVI-HSSGH-----------RVLIVQASAYARY 292
                   |.|:.|                ||..|| :..||           :...:|:..:|..
Yeast   241 -------HLPATDPTEREMHKIHALIRKYYPNTVIQYFGGHTHIRDFVQLDSKSTCLQSGRFAET 298

  Fly   293 VGNLIV----------------YFDDNGDVLDYEGDPLYMDQSVPEDDIVLQAMVPWQLEMKPIA 341
            ||.|.:                |.|.|.:...|....|..|.:||..          ..:.|.|:
Yeast   299 VGFLSINMTDPVDAESPIFSRRYIDFNKEAFKYHLSKLGHDSNVPVS----------TKKGKTIS 353

  Fly   342 ERTVGQSR--VNLQQ------------SQCSSGECNLGNFFTDAMLHAFVKDASSSSEESWSNVT 392
             |.|...|  :||.:            ::..:.|.||.:..|..:|...:  ...:.|.|.|.
Yeast   354 -RLVNDLRHELNLNEKLGYIPQTYYVSTRPLNSEENLYHLITHKILPNLI--PPKNYEPSMSR-- 413

  Fly   393 IALTSTGTFRVPIPAGNITYKQLFAMCPWQN--RLVTLSLRGKHIVELLEHVVA----------P 445
            ..|.:||:.|..:..|..|....:.:.|:.|  |.:|:.|           |||          |
Yeast   414 FILINTGSVRYDLYKGPFTKDTEYIVMPFNNDWRFITVPL-----------VVASRVETYLNKGP 467

  Fly   446 MNASSATPRSSRFLQVSG 463
            :.||...|.||...|..|
Yeast   468 VIASLGIPSSSHHKQHFG 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42249	NP_572684.2	MPP_CD73_N	36..316	CDD:277354	66/353 (19%)
		5_nucleotid_C	345..520	CDD:427027	34/145 (23%)
SMN1	NP_012072.3	MPP_YHR202W_N	39..325	CDD:277352	63/337 (19%)