Protein Alignment C901 and JAG2

DIOPT Version :10

• Sequence 1: NP_572673.1
• Gene: C901 / 32032
• FlyBaseID: FBgn0021742
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_002217.3
• Gene: JAG2 / 3714
• HGNCID: 6189
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 127/443 - (28%)
• Similarity: 173/443 - (39%)
• Gaps: 143/443 - (32%)

  Fly    48 CEKSQKQRQN--AHYVCDEKGDFKCLPGWQGDLCQVPMCRRGCDPMNGYCQRPGECRCRIGYSGE 110
            |.|..:.|.:  .||.||:.|:..|:.||.|..|:..:|::||:.::|.|..||||||..|:.|.
Human   207 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGR 271

  Fly   111 LCDKCIPLPGCQHGGCTKPFECICKPGWAGLFC---------------------TEP-----SCR 149
            .||:|:|.|||.||.|.:|::|.|:..|.||.|                     .||     :|.
Human   272 FCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336

  Fly   150 TG-----CHSTRGYC------------EAPG--ECRCRIGYAGRTCS----ECATMPGCQHGTC- 190
            .|     |......|            |.|.  ||.|..|::|.||:    |||:.|....|||
Human   337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCV 401

  Fly   191 ---------------------------NKP-------------LECLCLPGYTGLLCQTPICDPD 215
                                       .||             ..|.|:||:.|:.|...:  .|
Human   402 DQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINV--ND 464

  Fly   216 CSKQHGYCRKPGECR---------CKVGWTGSQC----DKCFPYPGCANGDCE---APWECNCHP 264
            |   .|.|:..|.|:         |..|:.|..|    |:|...|..:.|.||   ..:.|:|..
Human   465 C---RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQ 526

  Fly   265 GWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRDDFLLTSEAPPR 329
            |:.|.||:..:..|  .|..|.||.:|.:|   :|.|.|.|...|.||||.:           ||
Human   527 GFSGPLCEVDVDLC--EPSPCRNGARCYNL---EGDYYCACPDDFGGKNCSV-----------PR 575

  Fly   330 ITPPTPAELVLELDGELDQNGQQDIGAGVPDDSE-----PGGGLVGEKLPAGN 377
              .|.|......:||     ...|.|.|:|..:.     |.|..|.:  |.||
Human   576 --EPCPGGACRVIDG-----CGSDAGPGMPGTAASGVCGPHGRCVSQ--PGGN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C901	NP_572673.1	DSL	<56..82	CDD:473190	10/27 (37%)
		EGF_CA	280..315	CDD:238011	14/34 (41%)
JAG2	NP_002217.3	MNNL	28..196	CDD:462222
		DSL	178..240	CDD:128366	12/32 (38%)
		EGF_CA	307..345	CDD:238011	4/37 (11%)
		EGF	351..381	CDD:394967	8/29 (28%)
		EGF_CA	385..421	CDD:238011	7/35 (20%)
		EGF_CA	423..458	CDD:238011	7/34 (21%)
		EGF_CA	461..496	CDD:238011	9/39 (23%)
		EGF_CA	500..534	CDD:238011	11/33 (33%)
		EGF_CA	536..571	CDD:238011	14/39 (36%)
		EGF_CA	636..671	CDD:238011
		EGF_CA	676..709	CDD:238011
		EGF	716..746	CDD:394967
		EGF_CA	757..787	CDD:238011
		EGF_CA	789..824	CDD:238011
		EGF_CA	827..863	CDD:238011
		VWC_out	872..943	CDD:214565
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1238