DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sofe and prc1

DIOPT Version :9

Sequence 1:	NP_001285092.1	Gene:	sofe / 32016	FlyBaseID:	FBgn0030242	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_031753562.1	Gene:	prc1 / 100216075	XenbaseID:	XB-GENE-963901	Length:	620	Species:	Xenopus tropicalis

Alignment Length:	615	Identity:	157/615 - (25%)
Similarity:	263/615 - (42%)	Gaps:	118/615 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPQAC-EDCLARLKD---------------------HVHTFYTDLRKETSDKEQGILNDIAVLRN 72
            |..|| ...||||:|                     ||:...|.:.:|..:.:|.:|..|.|.|.
Frog    19 ESVACLNSALARLRDIWEEIGIPEDQRLQRTDAVKRHVNLLLTRMIEEEENLKQRLLKSIDVCRK 83

  Fly    73 EASGLRRLLHKAVDIGERPDDVPMEIWYIKLEK----YIEQLRKELVSRRAEIRELLHQQQQLCD 133
            |.:.|      .:::...|.:...|...::|||    .:|.:.|:...|..|::.|..:.|.|||
Frog    84 ELNTL------CMELQLPPFEEEEESTILQLEKDLRTRVEVMLKQKKERMHELKLLKERDQDLCD 142

  Fly   134 ELGEQPLSLLADPLPLPEEMDPFREHLAQLRDQRVQR--------------LRDMDELRQ-NIKR 183
            .|...|..:....:|..:|:|.||.|||.|..::..|              :.::|.|.. :.:|
Frog   143 ILCTSPYHIDGACVPSLQELDQFRRHLAGLSAEKEHREAEFKSTKKQIILCMEELDRLPDTSFER 207

  Fly   184 NIKLLELQLRTDSEKRLLNADNHKLTPYAYVRLQEMDKEFADQVQDLIDRIDEMRGKIECLWQRL 248
            ::      :..|.|...|:.:|  ||....:.:|..:::..:||     ..:|:|.||..||:||
Frog   208 DV------VCEDEEAFCLSKEN--LTALQELLIQLEEQKMKNQV-----LCEELRSKITELWERL 259

  Fly   249 RMTDEYAMRRVREATSYNQCTYDILREELERCQAMRQQNLIAFIEQLRIEINEWWDLSLKSTEER 313
            ::::|.........|.....|...|:||.:|.|.::.||:...:|.:|:||:.:||....|..:|
Frog   260 QISEEERDAFAEYMTGSKGKTIKALQEEFDRLQELKLQNIKRIVEAIRLEISSYWDKCFYSAAQR 324

  Fly   314 RRFTTYYCDTQTEDVLEQFEKELDNLKEFYNSNRKIFELYANRGELWTRMEALEAKANDPNRFNN 378
            :.|..:..:...||:|...:.|:..:|::|.|::::|:......|.|......:.||.|||||.|
Frog   325 QAFVPFSSEDYNEDLLCIHDAEISRIKQYYESHKEMFDGVQKWEENWRLFLEFDKKATDPNRFTN 389

  Fly   379 RGGQLLKEEKERKTIMSRLPKIDQQITELVQVYMSETHTPFLVHGVDILERMSADWERHRQSK-- 441
            |||.||||||:|..:...|||:::::...:..:..|....|.|:....::.::..||...|.|
Frog   390 RGGNLLKEEKQRAKLQKMLPKLEEELKTSIIAWEQEQGQEFFVNEKKFMDYVAEQWETFHQDKER 454

  Fly   442 -KQPSAQKKDGSNTSGQMKPPMVPLTPNTQKSNRGIHGSTSSLKKTPTKANASTTAMSTGNLHKR 505
             ||....||                  |.|......:||.   .|||               :||
Frog   455 EKQERLMKK------------------NRQLEEEMYYGSA---PKTP---------------NKR 483

  Fly   506 RHPQHHNTNSPQPAAAAKRNLIASLECNNASRKVCVNGQKLLKSPQRKVRVLEYSVRRGKGSGRP 570
            |.|   ..::|. :...|.|..:....:|::.:...:| .:..||..:..|.         .|:|
Frog   484 RVP---GPSTPS-SKCRKLNGTSISSSSNSTLRSAFSG-TMCHSPVSRPPVC---------GGKP 534

  Fly   571 STGSRNPQKI--RPIPKIHVRPPSGEENES 598
            ...||.|.::  .|.||   |....:||.|
Frog   535 GLPSRTPTRVFKTPQPK---RLEKNKENMS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sofe	NP_001285092.1	MAP65_ASE1	36..598	CDD:281928	153/606 (25%)
prc1	XP_031753562.1	MAP65_ASE1	46..620	CDD:397896	149/588 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2835
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3615
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D272248at2759
OrthoFinder	1	1.000	-	-		FOG0001893
OrthoInspector	1	1.000	-	-		mtm9438
Panther	1	1.100	-	-	O	PTHR19321
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3175
SonicParanoid	1	1.000	-	-		X857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190