Protein Alignment CG15306 and Sry

DIOPT Version :10

• Sequence 1: NP_572618.1
• Gene: CG15306 / 31961
• FlyBaseID: FBgn0030191
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_035694.1
• Gene: Sry / 21674
• MGIID: 98660
• Length: 395
• Species: Mus musculus
• Alignment Length: 166
• Identity: 42/166 - (25%)
• Similarity: 66/166 - (39%)
• Gaps: 10/166 - (6%)

  Fly   188 DEDSQHTDKKDEDSRDQGSQYEDSPGMDSQYKDCRDQDSQYEDSHGKDSQYKD--CRDQGSQYED 250
            |....|.:::..|...|..|:.     |.|.:..:.|..|:.|.|.:..|:.|  ...|..|:.|
Mouse   204 DHHHHHQEQQFHDHHQQQQQFH-----DHQQQQQQQQQQQFHDHHQQKQQFHDHHHHQQQQQFHD 263

  Fly   251 SHGMDSQYEDSRDQDSQYEDSPGMDSQYKDSRDQDSQYEDSHGKD---SQYKDCRDQGSQYEDSH 312
            ......|:.|.:.|..|:.|.|....|:.|...|..|:.|.|.:.   .|:.|...|..|:.|.|
Mouse   264 HQQQQQQFHDHQQQQHQFHDHPQQKQQFHDHPQQQQQFHDHHHQQQQKQQFHDHHQQKQQFHDHH 328

  Fly   313 GMDSQYKDSRDQGCQYEDSHGKDSEDEDSQYEDSQD 348
            ....|:.|...|..|:.|.|.:..:.:..|.:...|
Mouse   329 QQKQQFHDHHQQQQQFHDHHQQQQQQQQQQQQQFHD 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15306	NP_572618.1	CH	18..124	CDD:425596
		MSCRAMM_ClfA	<185..346	CDD:468110	41/162 (25%)
Sry	NP_035694.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066	4..81
		HMG-box_SoxA_SoxB_SoxG	4..79	CDD:438837
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	6..22
		Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066	52..84
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	75..81
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996	92..144
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090	94..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..361		41/161 (25%)