Protein Alignment LysRS and MSK1

DIOPT Version :10

• Sequence 1: NP_727353.1
• Gene: LysRS / 31904
• FlyBaseID: FBgn0027084
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_014326.1
• Gene: MSK1 / 855651
• SGDID: S000005017
• Length: 576
• Species: Saccharomyces cerevisiae
• Alignment Length: 587
• Identity: 191/587 - (32%)
• Similarity: 284/587 - (48%)
• Gaps: 109/587 - (18%)

  Fly    78 SAAEEEEISPNEYFKLRSAAVQELKRSPATDPYPHKFHVSSSLEDFIAKY---------ENSLKE 133
            |.|...:.|..|..:.....|::|.|.     ||..  ..|:|.|...:|         |..|..
Yeast    30 SLAHAVDTSKMEATRRNGQIVKDLGRY-----YPSM--SESALHDLCQEYKEVTIADFNERFLGN 87

  Fly   134 GETLE-----NVKLSVAGRVHAIRESGAKLIFYDL--RGEGVK----VQVMAS----AKSYKSEA 183
            ..||.     |:.||:.||:.:||.||.|::|.||  ...|:|    :|::.:    ..|.:.:|
Yeast    88 PATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKA 152

  Fly   184 DFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLP--------HLHFGLKDKE 240
            :|....:.|::||.|..:|:||.::        |.:|:||...:.||        .|...|.|:.
Yeast   153 NFSEYMNFLKKGDYIKALGYPGFSQ--------SRVKMLSLICNKLPIVLSVSQLPLPSRLNDET 209

  Fly   241 TRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHND 305
            .....|.:|..||..  :...:||:||..:|:|||...|:|:|||:::..:.||.||||:|...|
Yeast   210 KIKSNRVVDYQLNGT--QTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKD 272

  Fly   306 LKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDIT 370
            .. .|.:||||||:.|.|::.||.:|||||:.|||||||.|||.||:|.|||..|....||:..|
Yeast   273 FD-HLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRT 336

  Fly   371 EQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTP---PFKRVSMIKTLEEKLQVK--------- 423
            |.|...::..::..::....|......|..|..:.   .|::|..:.||.::|.:.
Yeast   337 EDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDIN 401

  Fly   424 -----------------FPAADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEE- 470
                             ||:||     .|.| ||.|               ::|:||...|:|:
Yeast   402 KPSELLKALPKDIAKKYFPSAD-----NTGQ-LSSL---------------QILNKLSDVFLEQR 445

  Fly   471 FCVN--PTFICEHPQIMSPLAKYHRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQAS 533
            .|.:  ||.|...|.|:|||||.......:|:|||:|:..||..|||.|.|.|.:|.::|.||..
Yeast   446 HCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQ 510

  Fly   534 -DKAAGDDEAQL---VDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDA 594
             ::..|:....|   :|..:..:::||:||.||||:|||||.|...|...|:|||.|..:  :|.
Yeast   511 INELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCV--DDV 573

  Fly   595 NR 596
            ||
Yeast   574 NR 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_727353.1	PLN02502	42..593	CDD:215278	188/582 (32%)
MSK1	NP_014326.1	class_II_aaRS-like_core	41..573	CDD:444800	185/572 (32%)