Protein Alignment: LysRS and MSK1

• Sequence 1: NP_001188571.1
• Gene: LysRS
• FlyBaseID: FBgn0027084
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_014326.1
• Gene: MSK1
• SGDID: S000005017
• Length: 576
• Species: Saccharomyces cerevisiae
• Alignment Length: 587
• Identity: 191/588 (32%)
• Similarity: 284/588 (48%)
• Gaps: 109/588 (19%)

  Fly    78 SAAEEEEISPNEYFKLRSAAVQELKRSPATDPYPHKFHVSSSLEDFIAKY---------ENSLKE 133
            |.|...:.|..|..:.....|::|.|.     ||..  ..|:|.|...:|         |..|..
Yeast    30 SLAHAVDTSKMEATRRNGQIVKDLGRY-----YPSM--SESALHDLCQEYKEVTIADFNERFLGN 87

  Fly   134 GETLE-----NVKLSVAGRVHAIRESGAKLIFYDL--RGEGVK----VQVMAS----AKSYKSEA 183
            ..||.     |:.||:.||:.:||.||.|::|.||  ...|:|    :|::.:    ..|.:.:|
Yeast    88 PATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKA 152

  Fly   184 DFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLP--------HLHFGLKDKE 240
            :|....:.|::||.|..:|:||.::        |.:|:||...:.||        .|...|.|:.
Yeast   153 NFSEYMNFLKKGDYIKALGYPGFSQ--------SRVKMLSLICNKLPIVLSVSQLPLPSRLNDET 209

  Fly   241 TRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHND 305
            .....|.:|..||..  :...:||:||..:|:|||...|:|:|||:::..:.||.||||:|...|
Yeast   210 KIKSNRVVDYQLNGT--QTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKD 272

  Fly   306 LKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDIT 370
            .. .|.:||||||:.|.|::.||.:|||||:.|||||||.|||.||:|.|||..|....||:..|
Yeast   273 FD-HLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRT 336

  Fly   371 EQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTP---PFKRVSMIKTLEEKLQVK--------- 423
            |.|...::..::..::....|......|..|..:.   .|::|..:.||.::|.:.
Yeast   337 EDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDIN 401

  Fly   424 -----------------FPAADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEE- 470
                             ||:||     .|.| ||.|               ::|:||...|:|:
Yeast   402 KPSELLKALPKDIAKKYFPSAD-----NTGQ-LSSL---------------QILNKLSDVFLEQR 445

  Fly   471 FCVN--PTFICEHPQIMSPLAKYHRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQAS 533
            .|.:  ||.|...|.|:|||||.......:|:|||:|:..||..|||.|.|.|.:|.::|.||..
Yeast   446 HCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQ 510

  Fly   534 -DKAAGDDEAQL---VDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPEDA 594
             ::..|:....|   :|..:..:::||:||.||||:|||||.|...|...|:|||.|..:  :|.
Yeast   511 INELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCV--DDV 573

  Fly   595 NR 596
            ||
Yeast   574 NR 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	188/583 (32%)
		LysRS_N	141..250	CDD:239817	36/127 (28%)
		LysRS_core	253..591	CDD:238398	133/374 (36%)
MSK1	NP_014326.1	lysS_bact	41..573	CDD:273107	186/573 (32%)
		LysRS_N	101..219	CDD:239817	36/126 (29%)
		class_II_aaRS-like_core	220..572	CDD:294192	134/378 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG1190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950		0	Normalized mean entropy	S299
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR42918
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	4	3.910