DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LysRS and krs1

DIOPT Version :9

Sequence 1:	NP_001188571.1	Gene:	LysRS / 31904	FlyBaseID:	FBgn0027084	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_595892.1	Gene:	krs1 / 2539746	PomBaseID:	SPBC17G9.03c	Length:	591	Species:	Schizosaccharomyces pombe

Alignment Length:	574	Identity:	357/574 - (62%)
Similarity:	435/574 - (75%)	Gaps:	18/574 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VSAPQMEP---SKQTKLELKRRLKAE----QKAKEKAEKAAAAPAENTAGKKKSSAAEEEEISPN 88
            |.|..::|   .:.:|.|||:|.|..    .|||::|||||:||    ....|||:.:||::.|:
pombe    13 VKALVLDPVTGEQVSKTELKKREKQRARELAKAKKQAEKAASAP----VAAPKSSSKKEEDLDPS 73

  Fly    89 EYFKLRSAAVQELKRSPATDPYPHKFHVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRE 153
            :||:.||..:.||:::...:||||||.|:.:|.:|||||| .|..|||...|:::|||||..:|.
pombe    74 QYFENRSRTIMELRQTKDPNPYPHKFQVTITLPEFIAKYE-GLARGETKPEVEVAVAGRVLGLRT 137

  Fly   154 SGAKLIFYDLRGEGVKVQVMASAKSYKSEADFEIDTSKLRRGDIIGVVGHPGKTK-----KGELS 213
            :|.||.||::..:|.|:|||..|:. ....||......||||||||:.|:||::.     .||||
pombe   138 AGNKLRFYEIHADGKKLQVMCQAQD-ADTVDFAAQHEHLRRGDIIGIRGYPGRSNPKGRADGELS 201

  Fly   214 VMPSEIKLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNNNVREKFQIRAKIISYVRQFLDRLG 278
            :...:..||||||.|||..|:||||.|.|:||||||||:|.:.|::|.:|::||.|:|.|.|...
pombe   202 IFARQCVLLSPCLRMLPKEHYGLKDLEIRHRQRYLDLIMNRSTRDRFVMRSRIIQYIRHFFDSRD 266

  Fly   279 FLEIETPMMNMIAGGATAKPFVTHHNDLKMDLFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGI 343
            |:|:||||||||||||||||||||||||.|||:||||||||.||||||||||||||||||||||.
pombe   267 FMEVETPMMNMIAGGATAKPFVTHHNDLDMDLYMRIAPELYLKMLVVGGLDRVYEIGRQFRNEGA 331

  Fly   344 DLTHNPEFTTCEFYMAYADYADIMDITEQLVSGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFK 408
            |||||||||:.|||.|||||.|:||.||:|:||:||.:.|||||.|||||||||:.||||:.|::
pombe   332 DLTHNPEFTSIEFYQAYADYYDLMDTTEELLSGLVKDLTGSYKVPYHPEGPEGPKWELDFSRPWR 396

  Fly   409 RVSMIKTLEEKLQVKFPAADTFNSPETNQFLSQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCV 473
            |::||:.|||||..|||..|..::||.|.||..|||||.|||..|:|.:||||||||||||..|:
pombe   397 RINMIEYLEEKLNTKFPPGDQLHTPEANAFLRDLCAKHGVECAPPQTCSRLLDKLVGEFIESECI 461

  Fly   474 NPTFICEHPQIMSPLAKYHRSIPGLTERFELFVAKKEICNAYTELNDPVVQRERFEQQASDKAAG 538
            |||||..|||:||||||||||..||.||||.|||.||||||||||||...||.|||:||..||.|
pombe   462 NPTFIIGHPQMMSPLAKYHRSDAGLCERFEAFVATKEICNAYTELNDIFDQRARFEEQARQKAQG 526

  Fly   539 DDEAQLVDENFCTSLEYGLPPTGGFGMGIDRLAMFLTDSNNIKEVLLFPAMKPE 592
            |||||::||||||:||||||||||:|||:|||.|||||||.|:||||||.||||
pombe   527 DDEAQIIDENFCTALEYGLPPTGGWGMGVDRLVMFLTDSNTIREVLLFPHMKPE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LysRS	NP_001188571.1	PLN02502	42..593	CDD:215278	354/560 (63%)
		LysRS_N	141..250	CDD:239817	55/113 (49%)
		LysRS_core	253..591	CDD:238398	246/337 (73%)
krs1	NP_595892.1	PLN02502	23..580	CDD:215278	352/562 (63%)
		LysRS_N	125..238	CDD:239817	55/113 (49%)
		LysRS_core	241..579	CDD:238398	246/337 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	534	1.000	Domainoid score	I41
eggNOG	1	0.900	-	-		E1_COG1190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4053
Inparanoid	1	1.050	702	1.000	Inparanoid score	I101
OMA	1	1.010	-	-		QHG53889
OrthoFinder	1	1.000	-	-		FOG0002656
OrthoInspector	1	1.000	-	-		oto100745
orthoMCL	1	0.900	-	-		OOG6_100559
Panther	1	1.100	-	-	LDO	PTHR42918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1446
SonicParanoid	1	1.000	-	-		X1764
TreeFam	1	0.960	-	-
	14	13.860