DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fum4 and fum1

DIOPT Version :9

Sequence 1:	NP_723527.1	Gene:	Fum4 / 318995	FlyBaseID:	FBgn0051874	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_588397.3	Gene:	fum1 / 2539345	PomBaseID:	SPCC18.18c	Length:	520	Species:	Schizosaccharomyces pombe

Alignment Length:	459	Identity:	241/459 - (52%)
Similarity:	328/459 - (71%)	Gaps:	3/459 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSAAETNKIHCLEEH 88
            |.|.|:.|.:.:|.::.:|.||.|||..|.|||.:||:|.||::|.|::|::||..|:...|:..
pombe    59 RQESDTFGPIQVPAEKYWGAQTQRSLQNFRIGGEKERLPLPLVRAFGVLKRAAASVNREFGLDPK 123

  Fly    89 LCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEILGGQMGSKEPVDPN 153
            |.|||.:|..:||.|:|  :::||||::|.|||..:|||.||||.|||||||||.:|||:||.||
pombe   124 LADAIEQAAQEVIDGRL--DDNFPLVVFQTGSGTQSNMNSNEVIANRAIEILGGTLGSKKPVHPN 186

  Fly   154 EHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIKIGRTHLMDAVPLS 218
            :||||:|||:|||.|.:.||..:|:...|.|:::.....|..|..::.::|||||||:.||.|||
pombe   187 DHVNMSQSSNDTFPTVMHIASVLQIHTHLLPAMKHLHRALKGKEEEFKNIIKIGRTHMQDATPLS 251

  Fly   219 LGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIKRIAELTFLPFVES 283
            ||||||||..|:..|..|::.|:.||..|..|||:|||.::|...:..:..:::::||.:.|..:
pombe   252 LGQEFSGYVTQVGYGIERINNALPRLCLLAQGGTAVGTGLNTFEGFDVKVAEKVSKLTNIEFKTA 316

  Fly   284 PNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPENEPGSSIMPGKVN 348
            ||.||:::|.|.:||:.|.||.||.|:||||||||.||||||||.|||.||.|||||||||||||
pombe   317 PNKFEALAAHDAIVEMSGALNVIACSLMKIANDIRQLGSGPRCGLGELILPANEPGSSIMPGKVN 381

  Fly   349 PTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGDGMKSFCTNCLEGI 413
            ||||||::|:||||||||..:::.|:|||.:||.|.|::|.|:|.||.||||..:||..:|:.||
pombe   382 PTQCEALTMVCAQVMGNHATITVAGASGHCELNVFKPLLAKNILSSIRLLGDACESFTDHCVVGI 446

  Fly   414 EPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAILDGI-QREDFREWVQP 477
            |||...|...:::||||||||:|||||:..|.|||.|..|.:||:.|.:..|. ..|.|.|||:|
pombe   447 EPNYEGIARHLRDSLMLVTALNPHIGYDNCAKIAKTALKNKSTLKHEFVTLGFGTPEQFDEWVRP 511

  Fly   478 SKML 481
            ..|:
pombe   512 ELMI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum4	NP_723527.1	fumC	22..483	CDD:234779	241/459 (53%)
Fum4	NP_723527.1	Fumarase_classII	24..480	CDD:176465	240/456 (53%)
fum1	NP_588397.3	fumC	57..519	CDD:234779	241/459 (53%)
fum1	NP_588397.3	Fumarase_classII	59..514	CDD:176465	240/456 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2304
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61095
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
TreeFam	1	0.960	-	-
	9	8.780