DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acp24A4 and Aplp1

DIOPT Version :9

Sequence 1:	NP_001036330.1	Gene:	Acp24A4 / 318936	FlyBaseID:	FBgn0051779	Length:	78	Species:	Drosophila melanogaster
Sequence 2:	NP_031493.2	Gene:	Aplp1 / 11803	MGIID:	88046	Length:	654	Species:	Mus musculus

Alignment Length:	60	Identity:	19/60 - (31%)
Similarity:	24/60 - (40%)	Gaps:	15/60 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLILLFVFIALASNSLALKNEICGLPAAAN--------GNC--LALF-----SRWSYDAQ 47
            |.:||.:.:.|....||:.|...|.|:||.        |.|  |.|.     .||..|.|
Mouse    20 LPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQ 79

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acp24A4	NP_001036330.1	Kunitz_BPTI	24..77	CDD:278443	12/39 (31%)
Aplp1	NP_031493.2	A4_EXTRA	46..211	CDD:128326	10/34 (29%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	50..146		8/30 (27%)
		APP_N	55..154	CDD:280358	8/25 (32%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	154..212
		APP_Cu_bd	156..211	CDD:289676
		Copper-binding	158..178
		Zinc-binding. /evidence=ECO:0000250	204..211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..297
		APP_E2	289..471	CDD:289677
		Heparin-binding. /evidence=ECO:0000250	314..346
		Heparin-binding. /evidence=ECO:0000250	414..445
		Collagen-binding. /evidence=ECO:0000250	446..463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..580
		Basolateral sorting signal. /evidence=ECO:0000250	608..619
		APP_amyloid	<612..651	CDD:287486
		Interaction with DAB1	636..652
		Interaction with DAB2. /evidence=ECO:0000269\|PubMed:11247302	640..654
		NPXY motif, contains endocytosis signal	644..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900