DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4B and NTO1

DIOPT Version :9

Sequence 1:	NP_001260942.1	Gene:	Kdm4B / 318918	FlyBaseID:	FBgn0053182	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_015356.1	Gene:	NTO1 / 856143	SGDID:	S000006235	Length:	748	Species:	Saccharomyces cerevisiae

Alignment Length:	510	Identity:	89/510 - (17%)
Similarity:	161/510 - (31%)	Gaps:	176/510 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DLDALNVTIPAPICQVVTGKQGYYQQINIQKKPLTVKQFSELASTERYAT----PKH---FDFED 114
            |.|.||..:....|.:.. .|..|..|.|.:.....::.  :.|...:||    |.|   |...|
Yeast   273 DSDNLNTIVFCDGCDIAV-HQECYGIIFIPEGKWLCRRC--MISKNNFATCLMCPSHTGAFKQTD 334

  Fly   115 ------------LERKYWKNITYVAPIYGADVSGSITDTDQDSWNIN------RLGTILD----- 156
                        |...|:.|:.|:.||.|      :.:.....|.:|      ::|..:.
Yeast   335 TGSWVHNICALWLPELYFSNLHYMEPIEG------VQNVSVSRWKLNCYICKKKMGACIQCFQRN 393

  Fly   157 ---------------YVNK---------------DYNIQ--------------IDGVNTAYLYFG 177
                           |::|               .|:::              |:|:|.|..||.
Yeast   394 CFTAYHVTCARRAGLYMSKGKCTIQELASNQFSQKYSVESFCHKHAPRGWQTSIEGINKARKYFS 458

  Fly   178 M---WKTTFAWHTE--DMDLYSINYLHFGAPKTWYVVPPECGRKLEKVANQYF-----PA-SYKN 231
            :   .:|....|.|  |......|...:..|....|.|......|:||.: :|     || ::..
Yeast   459 LLSTLQTETPQHNEANDRTNSKFNKTIWKTPNQTPVAPHVFAEILQKVVD-FFGLANPPAGAFDI 522

  Fly   232 CNAY-LRHKMTLISPQILKQHDVPVSKITQEAGEIMITFPFGYHAGFNHGFNCAESTNFAMERWI 295
            |..: ::.::|..:|......:..:..:|:|..:..|.|                 .|..:|
Yeast   523 CKYWSMKRELTGGTPLTACFENNSLGSLTEEQVQTRIDF-----------------ANDQLE--- 567

  Fly   296 EYGKRAVQCTCSNDMVKI-SMDTFVKRFQSDRYDLWMEGRDVGRHPEDPPNAVLSAAPLPPHLDV 359
                         |:.:: .:.|.||:.......|....:.|....:.|...:|....    ||:
Yeast   568 -------------DLYRLKELTTLVKKRTQASNSLSRSRKKVFDIVKSPQKYLLKINV----LDI 615

  Fly   360 LLCD---KKMKKQCNPTKAKSFKERNPDLDLDEIQQNPNVPDDVKAMLKESVL----TLDTGDLA 417
            .:..   |.:::.....|.....|:....|.|.:|           :.||.::    .|:|
Yeast   616 FIKSEQFKALERLVTEPKLLVILEKCKHCDFDTVQ-----------IFKEEIMHFFEVLET---- 665

  Fly   418 TDEADFPNEDAMSLQSPANLKTKQE------LLEYID-------DGTEDDDEEED 459
                 .|.  |..:....:.|.|::      |:|::|       |...:||:.|:
Yeast   666 -----LPG--ASRILQTVSSKAKEQVTNLIGLIEHVDIKKLLSRDFIINDDKIEE 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4B	NP_001260942.1	JmjN	11..44	CDD:280526
Kdm4B	NP_001260942.1	JmjC	173..289	CDD:202224	23/127 (18%)
NTO1	NP_015356.1	COG5141	18..748	CDD:227470	89/510 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900