Protein Alignment CG31643 and FASTKD1

DIOPT Version :10

• Sequence 1: NP_723145.1
• Gene: CG31643 / 318867
• FlyBaseID: FBgn0051643
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_078898.3
• Gene: FASTKD1 / 79675
• HGNCID: 26150
• Length: 847
• Species: Homo sapiens
• Alignment Length: 909
• Identity: 190/909 - (20%)
• Similarity: 360/909 - (39%)
• Gaps: 185/909 - (20%)

  Fly    69 PREQDALLTRLEEAKTGNQILDVLESCDG-LQSSHVVMGISLLWNIYHDAEQASKDA--ITDRVL 130
            |...:.|:.::.:.....|:...:|.... |....|.....:||.:........|:|  :.|...
Human    33 PISCEPLIIQMNKCTDEEQMFGFIERNKAILSEKQVGCAFDMLWKLQKQKTSLLKNAEYVRDHPQ 97

  Fly   131 LNVLPKLAPYVHQLEIDDLSRCYLYLRKM-----HIPNSEAVVEAVLTRSLQLIESQVDDEVIPL 190
            ...|..||....:|..||.....||:.:.     |.|    :|||::|.:.:.:|.      ..:
Human    98 FLTLHNLATNKFKLMNDDTLVNVLYVTQQFAGEAHDP----LVEALVTEAWRRLER------FDI 152

  Fly   191 TSLSRLSVGINLERDFFTPLVCRNFIPHLEHHINWCRSAEQVRLLSTCLFQLHFLIDEELFTRFK 255
            ..||..|..:..:..:|:||:.:  |..:.|..  ..:.:.:..||..:..:..||... |.:..
Human   153 KLLSEFSSCLADQHLYFSPLMGK--IADIVHRN--LETTQDLSSLSVLMVNISSLISRH-FQQQL 212

  Fly   256 LRLTEMMQSGVLSSETPKALLKVIHMLNIPVWSQTHTQLIREVMLVLRPCIHQ--------MESA 312
            :..||::...:.|||           :|:   :::..:.:|.|....:|.:.:        ::..
Human   213 VNKTELLFDTIDSSE-----------VNV---AKSIAKFLRNVRYRYQPLLERCNNVFLSNVDHL 263

  Fly   313 DLKSICR-----TFLHHQEPAALIEPLKKALE--KLLQEEGTADALFCAV-PFATPLQRDQYLHQ 369
            ||.||.:     .||.......:|...||..|  .|.....:...||.|: |.|.|.::.|.  :
Human   264 DLDSISKILSVYKFLQFNSFEFIIMAKKKLTEMIPLCNHPASFVKLFVALGPIAGPEEKKQL--K 326

  Fly   370 FKELLYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHLH----LRFLRH 430
            ...||.||:.     ......:||.|:  .|:|..|   |.::|.:.|...|||.    |..|:.
Human   327 STMLLMSEDL-----TGEQALAVLGAM--GDMESRN---SCLIKRVTSVLHKHLDGYKPLELLKI 381

  Fly   431 CQRYMNFNNNLGGTYRHL---ELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWK 492
            .|..         |:.|.   |...||..:.::.:::..   :|.:.:     ||....:.|...
Human   382 TQEL---------TFLHFQRKEFFAKLRELLLSYLKNSF---IPTEVS-----VLVRAISLLPSP 429

  Fly   493 KFPNFLLSKMLAMAPQLGIQDCFLLSRGMQIASELRFRQH----LPALAGMQLSTMDSI------ 547
            ......:|::.|:.||     |.|.:......|.||:.||    |..:...||..:..:
Human   430 HLDEVGISRIEAVLPQ-----CDLNNLSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDHYGRQ 489

  Fly   548 ------LIGCAERHLRDAEKDPLNASELSMIVRTLSHRKKLKNTVVYNQALAQYKNLHCNDLNSR 606
                  .:....:.|:..:.:....|.|..::.||.|                    ..:|:|..
Human   490 RLQHSNSLDLLRKELKSLKGNTFPESLLEEMIATLQH--------------------FMDDINYI 534

  Fly   607 VVRDMAYNFNASNFFVPELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMP--------ASVE 663
            .|.::|...:::::....||:.:.:...:|.:.:...|:..::.....|.|.|        ..|:
Human   535 NVGEIASFISSTDYLSTLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQ 599

  Fly   664 ALNHASEVLLRDFDQMSGLSVVQACLALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYP 728
            .||....:|       ....:|....:|...:..||.|:..:|.:||:.|::.::::.  ..:..
Human   600 HLNSYLGIL-------DPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLDSQLEIL--SPSRS 655

  Fly   729 ERVLNLVMQLNRTVCLDFPEANVPWFQQNYIEAQISKKSLIPSEST-TEVKQLLHQLLQNDKHFR 792
            .||...:|:|||:|||:.||..:|||...:  .|...|.:...:.| .::.::|.::|......:
Human   656 ARVQFHLMELNRSVCLECPEFQIPWFHDRF--CQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVK 718

  Fly   793 CNHTTPYGYQIDFVIHFDRDKNPIP--------------------------APPVEATMLDRITK 831
            .:..|||.:::||....|:.|.|:|                          .||       ...:
Human   719 ASVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPP-------GAER 776

  Fly   832 VAILLLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEHDWNSKYMASSTAKANYLK-CL 894
            :|:..|...:.|.| :..::|..::|.||||::||:|:||::.:|||..:::..|:.:||: |:
Human   777 IALEFLDSKALCRN-IPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMALSTKDARMDYLRECI 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31643	NP_723145.1	FAST_1	645..715	CDD:461999	16/77 (21%)
		FAST_2	735..817	CDD:462448	25/82 (30%)
		RAP	834..894	CDD:214932	20/60 (33%)
FASTKD1	NP_078898.3	RESC6-like	64..316	CDD:480594	57/280 (20%)
		RESC8-like	334..>629	CDD:467929	63/353 (18%)
		FAST_1	575..644	CDD:461999	16/75 (21%)
		FAST_2	662..743	CDD:462448	25/82 (30%)
		RAP	779..838	CDD:214932	20/59 (34%)