DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31643 and FASTKD1

DIOPT Version :9

Sequence 1:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001308975.1	Gene:	FASTKD1 / 79675	HGNCID:	26150	Length:	847	Species:	Homo sapiens

Alignment Length:	908	Identity:	189/908 - (20%)
Similarity:	361/908 - (39%)	Gaps:	183/908 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PREQDALLTRLEEAKTGNQILDVLESCDG-LQSSHVVMGISLLWNIYHDAEQASKDA--ITDRVL 130
            |...:.|:.::.:.....|:...:|.... |....|.....:||.:........|:|  :.|...
Human    33 PISCEPLIIQMNKCTDEEQMFGFIERNKAILSEKQVGCAFDMLWKLQKQKTSLLKNAEYVRDHPQ 97

  Fly   131 LNVLPKLAPYVHQLEIDDLSRCYLYLRKM-----HIPNSEAVVEAVLTRSLQLIESQVDDEVIPL 190
            ...|..||....:|..||.....||:.:.     |.|    :|||::|.:.:.:|.      ..:
Human    98 FLTLHNLATNKFKLMNDDTLVNVLYVTQQFAGEAHDP----LVEALVTEAWRRLER------FDI 152

  Fly   191 TSLSRLSVGINLERDFFTPLVCRNFIPHLEHHINWCRSAEQVRLLSTCLFQLHFLIDEELFTRFK 255
            ..||..|..:..:..:|:||:.:  |..:.|..  ..:.:.:..||..:..:..||... |.:..
Human   153 KLLSEFSSCLADQHLYFSPLMGK--IADIVHRN--LETTQDLSSLSVLMVNISSLISRH-FQQQL 212

  Fly   256 LRLTEMMQSGVLSSETPKALLKVIHMLNIPVWSQTHTQLIREVMLVLRPCIHQ--------MESA 312
            :..||::...:.|||           :|:   :::..:.:|.|....:|.:.:        ::..
Human   213 VNKTELLFDTIDSSE-----------VNV---AKSIAKFLRNVRYRYQPLLERCNNVFLSNVDHL 263

  Fly   313 DLKSICR-----TFLHHQEPAALIEPLKKALE--KLLQEEGTADALFCAV-PFATPLQRDQYLHQ 369
            ||.||.:     .||.......:|...||..|  .|.....:...||.|: |.|.|.::.|.  :
Human   264 DLDSISKILSVYKFLQFNSFEFIIMAKKKLTEMIPLCNHPASFVKLFVALGPIAGPEEKKQL--K 326

  Fly   370 FKELLYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHLH----LRFLRH 430
            ...||.||:.     ......:||.|:  .|:|..|   |.::|.:.|...|||.    |..|:.
Human   327 STMLLMSEDL-----TGEQALAVLGAM--GDMESRN---SCLIKRVTSVLHKHLDGYKPLELLKI 381

  Fly   431 CQR--YMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKK 493
            .|.  :::|...        |...||..:.::.:::..   :|.:.:     ||....:.|....
Human   382 TQELTFLHFQRK--------EFFAKLRELLLSYLKNSF---IPTEVS-----VLVRAISLLPSPH 430

  Fly   494 FPNFLLSKMLAMAPQLGIQDCFLLSRGMQIASELRFRQH----LPALAGMQLSTMDSI------- 547
            .....:|::.|:.||     |.|.:......|.||:.||    |..:...||..:..:
Human   431 LDEVGISRIEAVLPQ-----CDLNNLSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDHYGRQR 490

  Fly   548 -----LIGCAERHLRDAEKDPLNASELSMIVRTLSHRKKLKNTVVYNQALAQYKNLHCNDLNSRV 607
                 .:....:.|:..:.:....|.|..::.||.|                    ..:|:|...
Human   491 LQHSNSLDLLRKELKSLKGNTFPESLLEEMIATLQH--------------------FMDDINYIN 535

  Fly   608 VRDMAYNFNASNFFVPELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMP--------ASVEA 664
            |.::|...:::::....||:.:.:...:|.:.:...|:..::.....|.|.|        ..|:.
Human   536 VGEIASFISSTDYLSTLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQH 600

  Fly   665 LNHASEVLLRDFDQMSGLSVVQACLALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYPE 729
            ||....:|       ....:|....:|...:..||.|:..:|.:||:.|::.::::.  ..:...
Human   601 LNSYLGIL-------DPFILVFLGFSLATLEYFPEDLLKAIFNIKFLARLDSQLEIL--SPSRSA 656

  Fly   730 RVLNLVMQLNRTVCLDFPEANVPWFQQNYIEAQISKKSLIPSEST-TEVKQLLHQLLQNDKHFRC 793
            ||...:|:|||:|||:.||..:|||...:  .|...|.:...:.| .::.::|.::|......:.
Human   657 RVQFHLMELNRSVCLECPEFQIPWFHDRF--CQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVKA 719

  Fly   794 NHTTPYGYQIDFVIHFDRDKNPIP--------------------------APPVEATMLDRITKV 832
            :..|||.:::||....|:.|.|:|                          .||       ...::
Human   720 SVLTPYYHKVDFECILDKRKKPLPYGSHNIALGQLPEMPWESNIEIVGSRLPP-------GAERI 777

  Fly   833 AILLLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEHDWNSKYMASSTAKANYLK-CL 894
            |:..|...:.|.| :..::|..::|.||||::||:|:||::.:|||..:::..|:.:||: |:
Human   778 ALEFLDSKALCRN-IPHMKGKSAMKKRHLEILGYRVIQISQFEWNSMALSTKDARMDYLRECI 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	15/73 (21%)
		FAST_2	736..816	CDD:285557	24/80 (30%)
		RAP	834..894	CDD:214932	20/60 (33%)
FASTKD1	NP_001308975.1	FAST_1	575..642	CDD:284217	15/73 (21%)
		FAST_2	662..742	CDD:285557	24/81 (30%)
		RAP	779..838	CDD:214932	20/59 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147898
Domainoid	1	1.000	52	1.000	Domainoid score	I11567
eggNOG	1	0.900	-	-		E1_28HV5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4875
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352329at2759
OrthoFinder	1	1.000	-	-		FOG0007973
OrthoInspector	1	1.000	-	-		oto89657
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5917
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860