Protein Alignment Bsg and BSG

DIOPT Version :10

• Sequence 1: NP_723346.2
• Gene: Bsg / 318841
• FlyBaseID: FBgn0261822
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_001719.2
• Gene: BSG / 682
• HGNCID: 1116
• Length: 385
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 98/390 - (25%)
• Similarity: 154/390 - (39%)
• Gaps: 106/390 - (27%)

  Fly   334 GASGEQTTISAATSTRAMMGG---------GGGVAGAGFSAGASGPMLGAGGHMLMGGQGHQVHL 389
            ||||....:.|..|.:..:||         |..|....:.....||. .....:..|.:..:||:
Human    18 GASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPN-DTCSQLWDGARLDRVHI 81

  Fly   390 Q---HQ-TLLPVKMDKLV-----------PNYDNAEH-----QMKFY------------------ 416
            .   || ....:.:|.||           .|..:..|     ::|:.
Human    82 HATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTV 146

  Fly   417 -DIRSPLVLSCNVKD-GTPGGVLIWKKNGTAVTD--VPSLRGRFKLIADENKFIIDKTDTNDD-G 476
             |:.|.::|:|::.| .|......|.|.|..:.:  :|..:..||:            |::|. |
Human   147 EDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKV------------DSDDQWG 199

  Fly   477 KYSCEFDGVSKEIEVIARV-------VVRVPSNTAVVEGEKMSVTCSVVGTKPELTWTFANVT-- 532
            :|||.|   ..|....|.:       |..|.|:..:.|||...:.|......|...|.:..:|
Human   200 EYSCVF---LPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDS 261

  Fly   533 ----LTNATD-RFILKPDDNGVPNAILTLDNVTLD-DRGEYKCIGRNAANVYGGNTTTPASD--V 589
                |.|.:: ||.:.....   .:.|.::|:.:: |.|:|:|.|          |::..||  :
Human   262 EDKALMNGSESRFFVSSSQG---RSELHIENLNMEADPGQYRCNG----------TSSKGSDQAI 313

  Fly   590 TTVRVKGKFAALWPFLGICAEVLILCIIILIYEKRRNKSELEESD--------TDPQEQKKKRRN 646
            .|:||:...|||||||||.||||:|..||.||||||...::.:.|        :..|.|..|.:|
Human   314 ITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKN 378

  Fly   647  646
            Human   379  378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	Ig	423..481	CDD:472250	15/61 (25%)
		Ig strand B	423..426	CDD:409353	1/2 (50%)
		Ig strand C	436..440	CDD:409353	0/3 (0%)
		Ig strand E	463..467	CDD:409353	0/3 (0%)
		Ig strand F	477..481	CDD:409353	2/3 (67%)
		Ig_3	495..573	CDD:464046	21/92 (23%)
BSG	NP_001719.2	Ig0_BSG1	23..138	CDD:409534	19/115 (17%)
		Ig strand A	24..28	CDD:409534	0/3 (0%)
		Ig strand A'	29..35	CDD:409534	1/5 (20%)
		Ig strand B	38..47	CDD:409534	1/8 (13%)
		Ig strand C	52..60	CDD:409534	0/7 (0%)
		Ig strand C'	65..69	CDD:409534	0/3 (0%)
		Ig strand D	79..85	CDD:409534	2/5 (40%)
		Ig strand E	88..97	CDD:409534	0/8 (0%)
		Ig strand F	104..112	CDD:409534	0/7 (0%)
		Ig strand G	128..138	CDD:409534	0/9 (0%)
		Essential for interaction with KDR/VEGFR2. /evidence=ECO:0000269|PubMed:25825981	195..199		1/3 (33%)
		IG_like	228..318	CDD:214653	23/102 (23%)
		Ig strand B	238..242	CDD:409353	0/3 (0%)
		Ig strand E	283..287	CDD:409353	1/3 (33%)
		Ig strand F	298..303	CDD:409353	2/4 (50%)
		Ig strand G	311..314	CDD:409353	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..385		5/26 (19%)