DRSC/TRiP Functional Genomics Resources

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Protein Alignment lz and RUNX2

DIOPT Version :10

Sequence 1:NP_511099.2 Gene:lz / 31883 FlyBaseID:FBgn0002576 Length:826 Species:Drosophila melanogaster
Sequence 2:NP_001019801.3 Gene:RUNX2 / 860 HGNCID:10472 Length:521 Species:Homo sapiens


Alignment Length:441 Identity:143/441 - (32%)
Similarity:197/441 - (44%) Gaps:137/441 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346
            :||.|||||.:|.||||.||:|||.|||||:|||||||.||.|||.||:.||||||..|||||.:
Human   108 DHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNAS 172

  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPR--------- 402
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|||||||||||||         
Human   173 AVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDS 237

  Fly   403 ------SKTSPTGGPHYRALGLG-----QRPYIDGFPS---TKALHELESLRRS----------- 442
                  .:.|..|...:.::.:|     .||.::..||   .:...::...|::           
Human   238 KPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQS 302

  Fly   443 --AKVAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYS 505
              :.::.:|:.:..:.|..|:..                           |.|...:..:....|
Human   303 YPSYLSQMTSPSIHSTTPLSSTR---------------------------GTGLPAITDVPRRIS 340

  Fly   506 SPNSTINSDCQVYKPNAPHIQAAEMMGAGE---------WTNGSSSSAAAYYHSHAHHPHAHHAH 561
            . :.|..||..:: |:.  :......||.|         :.:.||.:.:.:.:...|:|..    
Human   341 D-DDTATSDFCLW-PST--LSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPAT---- 397

  Fly   562 AHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAH 626
                  ....||                 .|.||.:|:              ||.:    .|..:
Human   398 ------FTYTPP-----------------VTSGMSLGM--------------SATT----HYHTY 421

  Fly   627 LPAVLPEMHGHGFA-TDPYQTAG----YGGGNTG--------GGSASKSEL 664
            ||   |...|...: :.|:||:.    |.|.::|        ||..|.|.:
Human   422 LP---PPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRM 469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lzNP_511099.2 Runt 281..404 CDD:459963 95/136 (70%)
RUNX2NP_001019801.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..59
polyglutamine repeat 49..71
polyalanine repeat 73..89
Runt 102..230 CDD:459963 95/121 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..340 20/144 (14%)
Required for interaction with FOXO1. /evidence=ECO:0000250 242..258 2/15 (13%)
Herpes_BLLF1 <266..481 CDD:282904 45/283 (16%)
Interaction with KAT6A. /evidence=ECO:0000250 336..439 26/154 (17%)
Interaction with KAT6B. /evidence=ECO:0000269|PubMed:11965546 374..468 26/141 (18%)
RunxI 430..521 CDD:430037 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..521 4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

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