Protein Alignment lz and Runx3

DIOPT Version :10

• Sequence 1: NP_511099.2
• Gene: lz / 31883
• FlyBaseID: FBgn0002576
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_062706.2
• Gene: Runx3 / 12399
• MGIID: 102672
• Length: 423
• Species: Mus musculus
• Alignment Length: 544
• Identity: 164/544 - (30%)
• Similarity: 212/544 - (38%)
• Gaps: 201/544 - (36%)

  Fly   151 HPPAMVTSSSTSPTGNGWSSSTGDFKGITAVATA--TGGGVGGATQGATASTGATAAEVLAVSSS 213
            :.|..:...|||             :..|..:||  .|||.||
Mouse    13 YTPTFIRDPSTS-------------RRFTPPSTAFPCGGGGGG---------------------- 42

  Fly   214 ASVGSSSPTGGASNGTAHSGHSGHTGGHSSSTASNNNNNGASNSNSNNNNAVHQDLLWMERLVQK 278
             .:|.:|   ||.:..|.:|..|.|.....|..                     |:|
Mouse    43 -KMGENS---GALSAQATAGPGGRTRPEVRSMV---------------------DVL-------- 74

  Fly   279 RQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELR 343
              .:|.||||||.:|.||||.||:|||.|||||:|||||||.:|.|||.||:.||||||..||||
Mouse    75 --ADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELR 137

  Fly   344 NFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPT 408
            |.:..|||.||:||||||||||||||||||||||.|:|.|||||.:|||||||||||||.
Mouse   138 NASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRR----- 197

  Fly   409 GGPHYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVA 473
               |.:.:....:.:.|.|...:              ..||.:..:...:.|..:..::.|.
Mouse   198 ---HRQKIEDQTKAFPDRFGDLR--------------MRVTPSTPSPRGSLSTTSHFSSQAQ--- 242

  Fly   474 VTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYSSPNS------TINS-------DCQVYKPNA--- 522
             ||..|...:                  :.:|.|..      |:.|       |.:::.|.|
Mouse   243 -TPIQGSSDL------------------NPFSDPRQFDRSFPTLQSLTESRFPDPRMHYPGAMSA 288

  Fly   523 --PHIQAAEMMGAGEWTNGSSSSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVG 585
              |:  :|...|.   :.||.|.|.....|..||.:             ||||.|   .||.|
Mouse   289 AFPY--SATPSGT---SLGSLSVAGMPASSRFHHTY-------------LPPPYP---GAPQS-- 330

  Fly   586 VGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAHLPAVLPEMHGHGFATDPYQTAGYG 650
                                             ::|.:.|: ||.....:|....:..:..|..|
Mouse   331 ---------------------------------QSGPFQAN-PAPYHLFYGASSGSYQFSMAAAG 361

  Fly   651 GGN----------TGGGSASKSEL 664
            ||.          ..|.|.|...|
Mouse   362 GGERSPTRMLTSCPSGASVSAGNL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lz	NP_511099.2	Runt	281..404	CDD:459963	93/122 (76%)
Runx3	NP_062706.2	Runt	70..198	CDD:459963	95/166 (57%)
		RunxI	328..423	CDD:430037	15/94 (16%)