Protein Alignment dpy and Ltbp3

DIOPT Version :10

• Sequence 1: NP_001260032.1
• Gene: dpy / 318824
• FlyBaseID: FBgn0053196
• Length: 22949
• Species: Drosophila melanogaster
• Sequence 2: XP_038948570.1
• Gene: Ltbp3 / 83838
• RGDID: 62057
• Length: 1317
• Species: Rattus norvegicus
• Alignment Length: 1035
• Identity: 291/1035 - (28%)
• Similarity: 382/1035 - (36%)
• Gaps: 347/1035 - (33%)

  Fly    94 TNDCDKDGTKCTHGACLNG----VCHCNDGYGG----CNCVDKDENECKQRPCDV-FAHCTNTLG 149
            |::|..:...|.||.|:.|    .||||.||..    ..||  |.|||:..||.. ...|.||.|
  Rat   572 TDECRLNQNICGHGQCVPGPSDYSCHCNPGYRSHPQHRYCV--DVNECEAEPCGPGRGICMNTGG 634

  Fly   150 SFTCTCFPGYR----GNGFHCEDIDECQDPAIAARCVENAECCNLPAHFLCKCKDGY--EGDGEV 208
            |:.|.|..|||    ..|..|.|::||..|.:   |.:...|.|.|.|:.|.|..||  :.....
  Rat   635 SYNCHCNRGYRLHVGAGGRSCVDLNECAKPHL---CGDGGFCINFPGHYKCNCYPGYRLKTSRPP 696

  Fly   209 LCTDVDECRNPENCGPNALCTNTPGNYTC-SCPDGYVGNNPYREGCQDVDECSYPNVCGPGAICT 272
            :|.|:||||:|..| |:..|.|.||::.| :|..||  .:.....|:|::|||..:.|.|| .|.
  Rat   697 VCEDIDECRDPSTC-PDGKCENKPGSFKCIACQPGY--RSQGGGACRDINECSEGSPCSPG-WCE 757

  Fly   273 NLEGSYRCDCPPGYDGDGRSESGCVDQDECARTPCGRNADCLNTDGSFRCLCP--DGYSGDPMNG 335
            ||.|||||.|..||:                                     |  ||.|
  Rat   758 NLPGSYRCTCAQGYE-------------------------------------PALDGLS------ 779

  Fly   336 CEDVDECATNNPCGLGAECVNLGGSFQCRCPSGFVLEHD-PHADQLPQPLNTQQLGYGPGATDIA 399
            |.|:|||.|.|.|..|. |.|..|||||:|.||:.|..| .|
  Rat   780 CIDMDECETGNICHDGI-CTNTPGSFQCQCLSGYHLSRDRSH----------------------- 820

  Fly   400 PYQRTSGAGLACLDIDECNQPDGVAKCGTNAKCINFPGSYRCLCPSGFQGQGYLHCENINECQDN 464
                       |.|||||:.|   |.| ....|||..||||||||.|.:
  Rat   821 -----------CEDIDECDFP---AAC-IGGDCINTNGSYRCLCPQGHR---------------- 854

  Fly   465 PCGENAICTDTVGSFVCTCKPDYTGDPFRGCVDIDECTALDKPCGQHAVCENTVPGYNCKCPQGY 529
                      .||.              |.|.|||||:.....|..|..|||....|.|.|.:|:
  Rat   855 ----------LVGG--------------RKCQDIDECSQDPGLCLPHGACENLQGSYVCVCDEGF 895

  Fly   530 DGKPDPKVACEQVDV---NILCSSNFDCTNNAECIENQCFCLDGFEPIGSSCVDIDECRTHAEVC 591
            ....| :..||:|:.   ...|..|||.|         .||    :.:.::.|...||
  Rat   896 TLTQD-QHGCEEVEQPHHKKECYLNFDDT---------VFC----DSVLATNVTQQEC------- 939

  Fly   592 GPHAQCLNTPGSYGCECEAGYVGSPPRMACKQPCEDVRCGAHAYCKPDQNEAYCVCED--GWTYN 654
                 |.:....:|..||.            .||.       .|   ...|.:.:|.|  |:|.:
  Rat   940 -----CCSLGAGWGDHCEI------------YPCP-------VY---SSAEFHSLCPDGKGYTQD 977

  Fly   655 PSDVAAGCV---DIDECDVMHGPFGS--CGQNATCTNSAGGFTCACPPGFSGDPH-SKCVDVDEC 713
            .:.|..|..   |||||.:    ||:  | :...|.|:..|:.|.|..||..|.: .:|||||||
  Rat   978 NNIVNYGIPAHRDIDECIL----FGAEIC-KEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1037

  Fly   714 RTGASKCGAGAECVNVPGGGYTCRCPGNTIADPDPSVRCVPIVSCSANEDCPGNSICDATKRCLC 778
             ...|.|..|. |.|. .|||.|.|                         .|......|.::||.
  Rat  1038 -LDESNCRNGV-CENT-RGGYRCAC-------------------------TPPAEYSPAQRQCLS 1074

  Fly   779 PEPNIGNDCRHPCEALNCGAHAQCMLANGQAQCLCAPGYTGNSALAGGCNDIDECRANPCAEKAI 843
            || .:|.     ...::.|:.||..:                        |:|||:.........
  Rat  1075 PE-EMGE-----ARGISAGSRAQEEM------------------------DMDECQDPAACRPGR 1109

  Fly   844 CSNTAGGYLCQC-----PGGSSGDPYREGCITSKTVGCSDANPCATGETCVQDSYTGNSVCICRQ 903
            |.|..|.|.|:|     ||.|..|                   |...|:..:.......||..::
  Rat  1110 CVNLPGSYRCECHPPWVPGSSGRD-------------------CQLPESQAEHGPERREVCWGQR 1155

  Fly   904 GYERNSENGQCQ--------DVDECSVQRGKPACGLNALCKNLPGSYECRCPQGHNGNPFIMCEI 960
            |     |:|.|.        ..|:|..::|:   |....|:..|       |:|....
  Rat  1156 G-----EDGMCMGPLAGPALTFDDCCCRQGR---GWGTQCRPCP-------PRGTGSQ------- 1198

  Fly   961 CNTPECQCQSPYK----LVGNSCVLSGCSSGQ-----ACPSGAECISIAGGVSYCACPKGYQTQP 1016
            |.|.:.:..|.:.    |:|.|..:...||.:     .|.|| .|:...|| :.|.||.|:|.
  Rat  1199 CPTSQSESNSFWDTSPLLLGKSPRVDEDSSEEDSDECRCVSG-RCVPRPGG-AVCECPGGFQL-- 1259

  Fly  1017 DGS---CVDVDECEE---RGAQLCAFGAQCVNKPGSYSCHCPEGYQGDAYNGLCALAQRK 1070
            |.|   |||:|||.|   ||. ||. ..:|||..||:.|.|..|:.....:|.|...:|:
  Rat  1260 DASRARCVDIDECRELNQRGL-LCK-SERCVNTSGSFRCVCKAGFTRSRPHGACVPQRRR 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:463759	13/33 (39%)
		EGF_CA	212..247	CDD:238011	16/35 (46%)
		EGF_CA	255..>286	CDD:214542	16/30 (53%)
		EGF_CA	298..331	CDD:238011	4/34 (12%)
		EGF_CA	338..373	CDD:238011	19/34 (56%)
		EGF_CA	413..456	CDD:238011	20/42 (48%)
		EGF_CA	457..490	CDD:238011	2/32 (6%)
		EGF_CA	497..>529	CDD:214542	13/31 (42%)
		EGF_CA	580..>612	CDD:214542	6/31 (19%)
		EGF_3	676..702	CDD:463759	9/27 (33%)
		EGF_CA	1022..1056	CDD:214542	17/36 (47%)
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		Herpes_BLLF1	<4032..4489	CDD:282904
		Herpes_BLLF1	<4334..4797	CDD:282904
		PHA03255	4845..>5021	CDD:165513
		DUF5585	4959..5356	CDD:465521
		PHA03247	<5170..5799	CDD:223021
		PRK12495	<5749..5877	CDD:183558
		PHA03247	<5865..6485	CDD:223021
		Chi1	6385..>6609	CDD:442692
		Herpes_BLLF1	<6607..7102	CDD:282904
		Herpes_BLLF1	<7027..7490	CDD:282904
		DUF5585	7550..7954	CDD:465521
		DUF5585	7881..>8130	CDD:465521
		Atrophin-1	18652..>19081	CDD:460830
		PHA03247	<18873..19514	CDD:223021
		ZP	22576..22811	CDD:214579
Ltbp3	XP_038948570.1	TB	288..>318	CDD:459903
		EGF_CA	352..387	CDD:214542
		TB	411..452	CDD:459903
		PHA03247	<484..574	CDD:223021	1/1 (100%)
		EGF_CA	613..656	CDD:214542	17/42 (40%)
		EGF_CA	657..692	CDD:238011	13/37 (35%)
		EGF_CA	700..733	CDD:214542	16/35 (46%)
		EGF_CA	741..781	CDD:214542	22/83 (27%)
		EGF_CA	782..822	CDD:214542	21/74 (28%)
		EGF_CA	823..862	CDD:214542	23/82 (28%)
		EGF_CA	863..896	CDD:214542	14/32 (44%)
		TB	926..968	CDD:459903	12/79 (15%)
		EGF_CA	1033..>1061	CDD:214542	15/55 (27%)
		EGF_CA	1095..1135	CDD:214542	14/58 (24%)
		TB	1159..1195	CDD:459903	9/45 (20%)
		EGF_CA	1268..1306	CDD:214542	17/39 (44%)