DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and HEG1

DIOPT Version :10

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_065784.1 Gene:HEG1 / 57493 HGNCID:29227 Length:1381 Species:Homo sapiens


Alignment Length:1709 Identity:367/1709 - (21%)
Similarity:558/1709 - (32%) Gaps:579/1709 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  7140 PSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFE---SSTPRPVTLETAVPP 7201
            |..|..|...|.:|.....|......||        .|:.|.|.|.|   .:||.|    :...|
Human    33 PPPSPARRALSLAPLAGAGLELQLERRP--------EREPPPTPPRERRGPATPGP----SYRAP 85

  Fly  7202 VTSETTTNVPIGST--GGQVTEQTTPSPSEVRTTIRIEESTFPSRSTDRTT-------------- 7250
            .....|...|.|..  ||.........| |..|...:|..||.....|.:|              
Human    86 EPGAATQRGPSGRAPRGGSADAAWKHWP-ESNTEAHVENITFYQNQEDFSTVSSKEGVMVQTSGK 149

  Fly  7251 ---PSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFESSTPRPVTLEIA------------ 7300
               .|::||..|.|......|..|..::.:...:         .|...:||||            
Human   150 SHAASDAPENLTLLAETADARGRSGSSSRTNFTI---------LPVGYSLEIATALTSQSGNLAS 205

  Fly  7301 ----VPPVTSETTTNVAI-----GSTGGQVTEQ---------------TTS--SPSEVRTTIRVE 7339
                :|..:||....:|.     |:.....||:               |||  |||.: ..:.:.
Human   206 ESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFL-PALEMG 269

  Fly  7340 ESTLPSRSTDRTTP-----------SESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEAST 7393
            |.|.|||..:.:.|           :.||....:..|:.|.:.::....:|: .|..|:....:|
Human   270 ELTTPSRKRNSSGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSS-SVSQTKTMHVAT 333

  Fly  7394 ----PSPASLET-TVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRT 7453
                ..|.:|.: ||....:..|...|..|.....:......||.|       ||...||.|. .
Human   334 VFTDGGPRTLRSLTVSLGPVSKTEGFPKDSRIATTSSSVLLSPSAV-------ESRRNSRVTG-N 390

  Fly  7454 PPSESPETPTTLPSDF---TTRPHSDQTTESSRDVPTTQPFESSTP--RPVTLEIAVPPVT-SET 7512
            |..|....|:| .::|   :.|..:|..|.....:.::...::.:|  :..|:..:|.|:. .|.
Human   391 PGDEEFIEPST-ENEFGLTSLRWQNDSPTFGEHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEI 454

  Fly  7513 T-----TNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFT 7572
            |     ||   .:|...|||.:.:.|.      ||..|.| ::.:|.|..|....|.      ..
Human   455 TAHWLLTN---STTSADVTGSSASYPE------GVNASVL-TQFSDSTVQSGGSHTA------LG 503

  Fly  7573 TRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVP----SVTLETTTNVPIGSTGGQVTGQTTA 7633
            .|.:|:               .:||.|..||.::.|    |:.         |.:.|||.|    
Human   504 DRSYSE---------------SSSTSSSESLNSSAPRGERSIA---------GISYGQVRG---- 540

  Fly  7634 TPSEVRTTIGVEESTLPSRS-----------TDRTTPSESPETPTTL-------PSDFTTRPH-- 7678
            |..|.||:....:.|..|.:           ||.::.|:..|:.|:.       .|::::..|  
Human   541 TAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQ 605

  Fly  7679 SDQTTESTRDVPTTRPFEASTPRPVTLETAVPSVTSETTTNVPIGSTV--TSETTTNVPIGSTGG 7741
            ::::..|:.|....:|   ||..||...:.:||.|  .|.|:|..|.|  |.....:....|:..
Human   606 TERSNISSYDGEYAQP---STESPVLHTSNLPSYT--PTINMPNTSVVLDTDAEFVSDSSSSSSS 665

  Fly  7742 QVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVP 7806
            ..:..::.||           ..|||.|......|      :.|||   ||. |....:||.|..
Human   666 SSSSSSSGPP-----------LPLPSVSQSHHLFS------SILPS---TRA-SVHLLKSTSDAS 709

  Fly  7807 TTRPFEAS-TPSPASLETTVPSVTSETTTNVPIGSTGGQLTEQSTSSPSEVRTTIRVEESTLPSR 7870
            |  |:.:| :|.|.||.|                         |||:|      :.|.::|||..
Human   710 T--PWSSSPSPLPVSLTT-------------------------STSAP------LSVSQTTLPQS 741

  Fly  7871 STDRTFPSESPEKP-----TTLPSDFTTRPHLEQT----TEST---RDVLTTRPFETSTPSPVSL 7923
            |:....| .:.|.|     |:..:.|.|..|..||    ::||   ..|:|    |:.:||.|||
Human   742 SSTPVLP-RARETPVTSFQTSTMTSFMTMLHSSQTADLKSQSTPHQEKVIT----ESKSPSLVSL 801

  Fly  7924 ETTVPSVTSETSTNVPIGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPL 7988
            .|   ..|...:||.|:             |||:  ||:..:.|.||.|.:.       |...|.
Human   802 PT---ESTKAVTTNSPL-------------PPSL--TESSTEQTLPATSTNL-------AQMSPT 841

  Fly  7989 ESTTRLYTDQTI--PPGSTDRTTSSERPDESTRLTSEESTETTRP---VPTVSPRDALETTVTSL 8048
            .:||.|.|.|.:  .||:...|.|......:.:.|:.:....|.|   ||.:|....:.|....:
Human   842 FTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRV 906

  Fly  8049 ITETTKTTSGGTPRGQVTERTTKSVSELTT--GRSSDV-VTERTMPSNISSTTTVFNNSEPVSDN 8110
            |.:   .|:|..|...|    ..|..|:||  |.:::. ...|::.::.|..|||.:.:|.::..
Human   907 IVD---ATTGLIPLTSV----PTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPK 964

  Fly  8111 LPTTISITVTDSPTTV---------PVPTCKTDYDCLDEQTCIGGQCISPCEYFTNLCTVQNLTI 8166
            ..|....:.|.|||||         .|..|..:.:|:.:.|..|..|..|..:..:.|:|     
Human   965 SATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSV----- 1024

  Fly  8167 CRTLNHTTKCYCDTDDDVNRPDCSMKAEIGCASSDECPSQQACINALCVDPCTFNNPCSRNEDCR 8231
                            |||  :|         .|:.|||...|.|                    
Human  1025 ----------------DVN--EC---------LSNPCPSTAMCNN-------------------- 1042

  Fly  8232 VFNHQPLCSAEHGRTPG---CEHCPPGANCDPTTGAC--IKANVT--------ITTITTKNSTST 8283
                          |.|   |: ||.|...:  .|.|  ::..||        :.|...|:|...
Human  1043 --------------TQGSFICK-CPVGYQLE--KGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQ 1090

  Fly  8284 KIPTKPRTTANPNTGVKTTPTTTRVTTRNTTTTTTTTTTSSTSTESSTITSATNQTSKNQKPDTE 8348
            ::..:  .|...|......|:..|.|...:..:.....:..|     |.:.|:|.|.        
Human  1091 EVENE--ITKTLNMCFSALPSYIRSTVHASRESNAVVISLQT-----TFSLASNVTL-------- 1140

  Fly  8349 STTSHTDATRRYRDGENNITDTPTPRPTIQTTTLRGEGVMGDSQR---RSTTTPKMKTTRLDTSN 8410
                 .|...|.:...|:.      :.:.:...|.|      |||   |:.:..|.|:...|   
Human  1141 -----FDLADRMQKCVNSC------KSSAEVCQLLG------SQRRIFRAGSLCKRKSPECD--- 1185

  Fly  8411 EVPDTTSPWPIELPTTEGTTTEVYNTMFAPVVNTTDTSLINPCTVDTNCAPNEHCKLGH------ 8469
                                              .|||:   || |.:......||.|:      
Human  1186 ----------------------------------KDTSI---CT-DLDGVALCQCKSGYFQFNKM 1212

  Fly  8470 ---CRKKEPPGSPKTPEPCQSNNDCIESEACYMGL----CQDPCEFAKICAATA----------- 8516
               ||..| .|.....|.|.|         |..||    |.:|.:...:..|.|           
Human  1213 DHSCRACE-DGYRLENETCMS---------CPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGIA 1267

  Fly  8517 ---KCTAKSHR---------------PVCTCPQ-------GHEGNPMVKCVTTQTSIECTDDSDC 8556
               .|..|:..               |....|:       |.|...|.:..:|:..::.||    
Human  1268 LIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTD---- 1328

  Fly  8557 GVTEACINQLCQHPCDVHDPCATNAVCINSNHAADCSCADGFQGNG----FVGCQPARSHVC--- 8614
                     :...|..|.:|                    ..:.||    :.|. |...|.|   
Human  1329 ---------VYYSPTSVRNP--------------------ELERNGLYPAYTGL-PGSRHSCIFP 1363

  Fly  8615 -QYNEDCPPTKLCDRLNRR 8632
             |||    |:.:.|...||
Human  1364 GQYN----PSFISDESRRR 1378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:463759
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:463759
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
Herpes_BLLF1 <4032..4489 CDD:282904
Herpes_BLLF1 <4334..4797 CDD:282904
PHA03255 4845..>5021 CDD:165513
DUF5585 4959..5356 CDD:465521
PHA03247 <5170..5799 CDD:223021
PRK12495 <5749..5877 CDD:183558
PHA03247 <5865..6485 CDD:223021
Chi1 6385..>6609 CDD:442692
Herpes_BLLF1 <6607..7102 CDD:282904
Herpes_BLLF1 <7027..7490 CDD:282904 92/428 (21%)
DUF5585 7550..7954 CDD:465521 105/442 (24%)
DUF5585 7881..>8130 CDD:465521 74/277 (27%)
Atrophin-1 18652..>19081 CDD:460830
PHA03247 <18873..19514 CDD:223021
ZP 22576..22811 CDD:214579
HEG1NP_065784.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..108 22/86 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..325 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 376..447 18/79 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..529 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..680 20/83 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..757 21/84 (25%)
DUF5585 <724..>986 CDD:465521 84/329 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 774..830 23/77 (30%)
EGF 989..1021 CDD:394967 7/31 (23%)
EGF_CA 1025..1056 CDD:214542 16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

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