Protein Alignment mxc and NPAT

DIOPT Version :10

• Sequence 1: NP_572548.1
• Gene: mxc / 31869
• FlyBaseID: FBgn0260789
• Length: 1837
• Species: Drosophila melanogaster
• Sequence 2: XP_011541156.1
• Gene: NPAT / 4863
• HGNCID: 7896
• Length: 1436
• Species: Homo sapiens
• Alignment Length: 1720
• Identity: 343/1720 - (19%)
• Similarity: 555/1720 - (32%)
• Gaps: 570/1720 - (33%)

  Fly     4 IVLHSDVARLVLGYLVNQNLKRAAHTLCRTSPHLR----------------------------HE 40
            ::|.|||||||||||..:||.....|....|..|:                            :|
Human     1 MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNE 65

  Fly    41 FLALKQGLQTHNFLHGGLEEIICEHVKITSLVAGAVQKLPLDMRMQLQQMKLSERVSELIAAGER 105
            ::|:|....::|               :.::::...:||...: .|::.|:.|.|.     ||.:
Human    66 YVAMKTKETSNN---------------VPAIMSSLWKKLDHTL-SQIRSMQSSPRF-----AGSQ 109

  Fly   106 SSCTNESSTPGEPTISQSHRKRRRLRTHSPVNS--ISSPSFSKRPRLLPPHFYCSVNR------D 162
            .:.|...       |::..|:|:.....:|.::  ::.|..|.: ...||.....|.|      |
Human   110 RARTRTG-------IAEIKRQRKLASQTAPASAELLTLPYLSGQ-FTTPPSTGTQVTRPSGQISD 166

  Fly   163 KVRQSFL-----GSQDDCEAELDEEDGESTT----ATEDLEEDDLLPANGPGPRNNSTPRQGHTE 218
            ..|..|:     .|||....      ||:..    |.|......|:   .||.|.:.:.|:..|.
Human   167 PSRSYFVVVNHSQSQDTVTT------GEALNVIPGAQEKKAHASLM---SPGRRKSESQRKSTTL 222

  Fly   219 SNP------------LLLTPQSMPELAC-AIIKNQDFQETLVKNINVALQT---------VTVNN 261
            |.|            ..:..|.:.|.|. .|:.|:..||.|.:|||..|.:         .|.||
Human   223 SGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNN 287

  Fly   262 PS---VSCDAMLDGL----------VKNILEATEKDPSFDRIIQ-------------EVVIGDEP 300
            |:   .|.|..| ||          :::|||.||.||:|..:..             ...|..:|
Human   288 PTEPETSIDEFL-GLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQP 351

  Fly   301 LANEEDPGVSPASD----AAGAAIVPAADGDVLPTEQAVDPVPPQTPLIIRTAVAATAGTNADPN 361
            :  |.:|.:..|.:    ..|:.....:||      |:..|            ...|:..|.||.
Human   352 M--ESNPSIVLADETNLAVKGSFETEESDG------QSGQP------------AFCTSYQNDDPL 396

  Fly   362 FSISKLIVLNSNESVQKMVAGLDTSNISFTSEGLNINFADPASMLSEVEAT-------------- 412
            .::..    ::|..|.:.....:.|.||.:.:......|.|.....:::.|
Human   397 NALKN----SNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRG 457

  Fly   413 ----AAGQVCVDATTGQLTFPMYLSNG----GLLSHLPFLVNNEWVAQQLGPDAFANIDDSHIEI 469
                .....|.:..|.|::....::.|    .|.|::|       ...||.||.
Human   458 NSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVP-------SESQLQPDQ----------- 504

  Fly   470 SLPE-PIT------LSANQLPPNSIIISSAQKQPPPPSVEPPVQLIKDAAKVDNKAGQGTAAKEQ 527
              |: |||      ..||    |..:|.|.:..          ||:.....:..|..:.:...|.
Human   505 --PDIPITSFVSLGCEAN----NENLILSGKSS----------QLLSQDTSLTGKPSKKSQFCEN 553

  Fly   528 PIDQLEEEQRKFPPASLDSSR--------QVMERVTPSTSGIINVKAFRSLSTP-RKRTSHVRTL 583
            ..|.::.:.......|.|||.        .|:|.|....|...:....:|...| ...:||   |
Human   554 SNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSH---L 615

  Fly   584 TFSPKVPPGGVLHSNTPL-STRRPGLLAKAQEKPIINHVE-IIQAACDLSSNE------------ 634
            ..|.:|.    :|....| ||::|...:.:.|   :||.| ..||:...:|.|
Human   616 NVSGQVE----IHLGDSLSSTKQPSNDSASVE---LNHTENEAQASKSENSQEPSSSVKEENTIF 673

  Fly   635 -GLGGVPPLFAMEECSNQTVIRAHPPAAAP--SAAPVPPLVATPKRKQKRQAAVKACKRIISQAE 696
             .|||         .:|...:...||...|  ::..:||
Human   674 LSLGG---------NANCEKVALTPPEGTPVENSHSLPP-------------------------- 703

  Fly   697 SETKTDKDQKKIMPKNNSACSASSTAHDDSAEASKENLQEQQKIEGKPDVGSAARGDA------- 754
                            .|.||:...:|.:|           |..:.||...::|..||
Human   704 ----------------ESVCSSVGDSHPES-----------QNTDDKPSSNNSAEIDASNIVSLK 741

  Fly   755 -VVDNDMAAWQRQLHGSNSDLENRLREINSKREEVKASGRSRRPKKKDTPTSASSRARKAP---- 814
             ::.:|      ....|:::|.:.:..||.                ::.||...|...|:|
Human   742 VIISDD------PFVSSDTELTSAVSSING----------------ENLPTIILSSPTKSPTKNA 784

  Fly   815 -MVKAKAEPMNLAKKPQRSVGDSTEKINIKIITPQKPKLLKKKKVFEAKEEIIDETIEETIDETQ 878
             :||..:....:.......||||..         .:..||    .|::::..::.|..|......
Human   785 ELVKCLSSEETVGAVVYAEVGDSAS---------MEQSLL----TFKSEDSAVNNTQNEDGIAFS 836

  Fly   879 AEIEEKDQKKKSEQGCIYAKDQEQAKAL-AAELSRPNMAMLLDTPFKASPIGAGASGAVEDDTTS 942
            |.:..          |: :||....:.: |...:..|...:|.......|...|        |:.
Human   837 ANVTP----------CV-SKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALG--------TSV 882

  Fly   943 KEAGVGVAAIIP----PTPGMAIPP-LDTPYGKLPSSSFLFGSDTKSIMDTPQLSAITPGFRLTP 1002
            .::.|   .::|    |.....:|| |.||    |.|:.:|..:.....:..|.|||.....:.|
Human   883 SQSNV---VVLPGNSAPMTAQPLPPQLQTP----PRSNSVFAVNQAVSPNFSQGSAIIIASPVQP 940

  Fly  1003 -----FGQMPGTPIGSAAKTEYSSGSSYYRPD-EAEHTDANAQ-C--AIQQWG-DPQDKKQPKVR 1057
                 .|.:|.:.:|       .:|:::..|. :..|....|. |  :|.|:. .|:.:|...:|
Human   941 VLQGMVGMIPVSVVG-------QNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLR 998

  Fly  1058 STPKKKK-----VEAEDE---LSQQKNQELI---EMECSKKSL---------------------- 1089
            :.|...|     |::...   ...|||..::   ..|.|.||:
Human   999 NKPCIGKQVNNLVDSSGHSVGCHAQKNSFVLFCFRTEVSDKSIATDLGKKSEETTVPFPEESIVP 1063

  Fly  1090 -----H------------------PEDKHAEDNKKT-----PKRPEKPMDEHLKETENDGEKNET 1126
                 |                  |..|....||:.     |......:...||...|:..|.|.
Human  1064 AAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREK 1128

  Fly  1127 VLEKTPDAVKQPVVLSLEPTVLRR---VRSFGSE--------AVDSAESATA---GSFPSDQQQL 1177
              ||.|    .|.:||...:.:.|   :|...||        .::|...|||   ....||.::.
Human  1129 --EKPP----LPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQ 1187

  Fly  1178 PHYKLLPGLPEAIIEGSSNSSSSATSSSSSSSSSSSSSSSSSSSSSSSSSSHSGKGESRGEEANG 1242
            .:       ||       ||..|....:....|..|.:|....:....:||::....|.|.....
Human  1188 KN-------PE-------NSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKD 1238

  Fly  1243 ENADEKCSKKK----EMLLNIDNLSNISSTEDEEWLKAAGSEDAVLPMLAIDSQPGQLVSQDGE- 1302
            ...::..|...    |||.:|...|::|        :.|.|.|     |.:...||   |..||
Human  1239 LKQEQTKSASSLITTEMLQDIQRHSSVS--------RLADSSD-----LPVPRTPG---SGAGEK 1287

  Fly  1303 -VRYPIRNWLTPSKEQAQETDTSGEQQTKPTPPKPVAAPVPPPPLPLTPPAAPPPPPPPPPEADD 1366
             ...||.....||..:..|..::.:          |..|...|.||...||:         |...
Human  1288 HKEEPIDIIKAPSSRRFSEDSSTSK----------VMVPPVTPDLPACSPAS---------ETGS 1333

  Fly  1367 PSSVALPTASTSRQEHQRQQLNE---KRQRVVAKFKEQPQPIKGQGRKTANK-KLTAMRENAKLA 1427
            .:||.:..       |....|:.   .|.......|:..|..:...|.|..| |:..:.|..:.:
Human  1334 ENSVNMAA-------HTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNS 1391

  Fly  1428 NPSSQKSPKNRKHIE-PLKTKAAKKQIEPN 1456
            .|||    ||..:.. |:|.|..||:..|:
Human  1392 RPSS----KNLTNSSIPMKKKKIKKKKLPS 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mxc	NP_572548.1	PTZ00108	<1414..1643	CDD:240271	14/45 (31%)
NPAT	XP_011541156.1	NPAT_C	758..1436	CDD:434876	158/788 (20%)