DRSC/TRiP Functional Genomics Resources

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Protein Alignment mxc and Npat

DIOPT Version :10

Sequence 1:NP_572548.1 Gene:mxc / 31869 FlyBaseID:FBgn0260789 Length:1837 Species:Drosophila melanogaster
Sequence 2:NP_001074621.1 Gene:Npat / 244879 MGIID:107605 Length:1420 Species:Mus musculus


Alignment Length:1701 Identity:331/1701 - (19%)
Similarity:544/1701 - (31%) Gaps:548/1701 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IVLHSDVARLVLGYLVNQNLKRAAHTLCRTSPHLRHEFLALKQGLQTHNFLHGGLEEIICEHVKI 68
            ::|.|||||||||||..:||.....|....|.:|:.                      ..||...
Mouse     1 MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKE----------------------YAEHCTD 43

  Fly    69 TSLVAGAVQKLPLDMRMQLQQMKLSERVSELIAAGERSSCTNESSTPGEPTISQSHRKRRRLRTH 133
            ...:...:        :.|....|:..::|.:|...:.:..:      .|||..|..|:.. .|.
Mouse    44 EGFIPACL--------LSLFGKNLTTILNEYVAMKAKETSND------VPTIMSSLWKKLD-HTL 93

  Fly   134 SPVNSI-SSPSFSKRPRLLPPHFYCSVNRDKVRQSFLGSQDDCEAELDEE-------DGESTT-- 188
            |.:.|: |||.|:...|....:....:.    ||.:|.||   .|.:..|       .|:.||  
Mouse    94 SQIRSMHSSPGFAAHQRARTRNGIAEIK----RQRWLASQ---AAPVSSELLVLPYASGQFTTSP 151

  Fly   189 --ATEDL-------------------------------EEDDLLPA----------NGPGPRNNS 210
              ||:.:                               |..:::|.          ..||.|.:.
Mouse   152 LVATQAVKPTGPISTPVRSNIVVVNQSQPQSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSE 216

  Fly   211 TPRQGHTESNP-----------LLLTPQSMPELAC-AIIKNQDFQETLVKNINVALQT------- 256
            :.::..|.|.|           ..:..|.:.|.|. .|:.|:..||.|.:|||..|.:       
Mouse   217 SQKKSLTSSGPHSSRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSSVAQV 281

  Fly   257 --VTVNNPS---VSCDAMLDGL----------VKNILEATEKDPSFDRIIQEVVIGDEPLANEED 306
              .|.:||:   .|.|.:| ||          :::|||.||.||:|..:......| :...|:..
Mouse   282 PKQTDSNPTEPETSIDELL-GLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYG-KTKNNKNM 344

  Fly   307 PGVSPASDAAGAAIVPAADGDVLPTEQAVDPVPPQTPLIIRTA--VAATAGTNADPNFSIS---K 366
            |.:|.......:.||                :|.:|.|.|:::  ...:.|.:..|.|..|   :
Mouse   345 PQISSQPMETNSNIV----------------LPEETNLTIKSSFETEESDGQSGQPPFCTSYQNE 393

  Fly   367 LIVLN-----SNESVQKMVAGLDTSNISFTSEGLNINFADPASMLSEVEATAAGQVCVDATTGQL 426
            .::||     ::..|....:..:.|.||...:......|.||      |...|..:.:::.:...
Mouse   394 DVLLNDLKSGNSHDVLPQESQENFSQISSNIQKKTFKTAIPA------EQKCALDITLESVSNLS 452

  Fly   427 TFPMYLSNGGLLSHLPFLVNNEWVAQQLGPDAFANIDDSHIEISLPEPITLSANQLPPNSIIISS 491
            .|....|:.....|.     :|..|.|:..:|         |:::.|..:|||:       |:|.
Mouse   453 DFNQRGSSAECNEHC-----SELFASQIPTEA---------EVAVGEKNSLSAD-------ILSQ 496

  Fly   492 AQKQPPPPSVEPPVQLIKDAAKVDNKAGQGTAAKEQPIDQLEEEQRKFPPASLDSSRQVMERVTP 556
            :|.||..||| |....:....:.::|....:....|.:.|      ..|..:..|..|:.|    
Mouse   497 SQYQPDQPSV-PVTSFVSLGGETNDKNLVLSGKNSQLLSQ------STPLTTKPSKSQLCE---- 550

  Fly   557 STSGIINVK----AFRSLSTPRKRTSHVRTLTFSP-KVPPGGVLHSNTPLSTRRPGLLAKAQEKP 616
            :::.||.||    |..|..:.........|.|.|| ...|......|:||           |.||
Mouse   551 NSNNIIKVKTNPQASESADSSETANRKTETNTVSPAAAQPQADCQDNSPL-----------QSKP 604

  Fly   617 IINHVEIIQAACDLSSNEGLGGVPPLFAMEECSNQTVIRAHPPAAAPSAAPVPPLVATPKRKQKR 681
                                                     ||....|                 
Mouse   605 -----------------------------------------PPGIGES----------------- 611

  Fly   682 QAAVKACKRIISQAESETKTDKDQKKIMPKNNSACSASSTAHDDSAEASKENLQEQQKIEGKPDV 746
             ..|...::|....|....:||.      .:|.|.|...    :..|:..|.||.....|  |:.
Mouse   612 -LGVNVTEKIEIHLEEPAPSDKQ------LSNDAASVDL----NPTESKTEPLQSASAQE--PEP 663

  Fly   747 GSAARGDAVVDNDMAAWQRQLHGSNSDLENRLREINSKREEVKASGRSRRPKKKDTPTSASSRAR 811
            .|...||.:..:                   |.|.||..|.....|.....|..::.:|.|..: 
Mouse   664 PSVKDGDTIFLS-------------------LSEHNSCEEVALVLGEGNPVKNNNSLSSESGGS- 708

  Fly   812 KAPMVKAKAEPMNLAKKPQRSVG-DSTEKINIKIITPQKPKLLKKKKVFEAKEEIIDETIEETID 875
                |....|..|...|...|.. |::..:::|||....|.:....::..|...|..|.:...|.
Mouse   709 ----VGVSPETQNTDGKTSNSTEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPTIIL 769

  Fly   876 ETQAEIEEKDQKKKSEQGCIYAKDQEQAKALAAELSRPNMAMLLDTPFKASPIGAGASGAVED-- 938
            .:::.                ||:.|....|::|          :|......:..|.||::|.  
Mouse   770 SSKSP----------------AKNAEFVTCLSSE----------ETASAVVSVEVGDSGSMEQNL 808

  Fly   939 ----------DTTSKEAGVGVAAIIPPTPGMAIPPLDTPYGKL-PSSSFLFGSDTKSIMDT---- 988
                      :.|..|.|:..:|.:.|     ..|.|..|.:| |::|..||:.:..::.|    
Mouse   809 LVLKPEEPMVNNTQNEDGIAFSANVAP-----CVPKDGGYIQLMPTTSTAFGNSSNILIATCMTD 868

  Fly   989 -----PQLS----AITPGFRLTPFGQMP----GTP--------IGSAAKTEYSSGSSYY------ 1026
                 |.:|    .:.||.......|.|    .||        :..|....:|.||:..      
Mouse   869 STALGPTVSQSNVVVLPGSSAPMTAQPPQQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQ 933

  Fly  1027 ------------------------RPDEAEHTDANAQ-C--AIQQWGDPQDKKQPKVRSTPKKKK 1064
                                    .|.:..|....|. |  :|.|...||  |..|.:..  :.|
Mouse   934 PVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIAQLPIPQ--KSQKAQGL--RNK 994

  Fly  1065 VEAEDELSQQKNQELIEMECSKKSLHPEDKH--AEDNKKTPKR-----------PEKPMDEH--- 1113
            :....:::...|...:...|..:.....||:  .|..||....           |.||.:.|   
Mouse   995 LITGKQVNNLTNLSSLSEACHTQRTEASDKNIATELGKKMEDTTISLSGERVAPPSKPFESHRRV 1059

  Fly  1114 -----------------LKETENDGEKNETVLEKTPDAVKQPVVLS-LEPTVLRRVRSFGSEAVD 1160
                             .|.|..:.||.|.....    :..|::.| |:|.              
Mouse  1060 LCFDSTVSSVANTQGSLYKMTSENKEKKEASFSH----LDSPILSSTLKPP-------------- 1106

  Fly  1161 SAESATAGSFPSDQQQLPHYKLLPGLPEAIIEGSSNSSSSATS-----SSSSSSSSSSSSSSSSS 1220
                      |::..:....|.:|    .|:..|..:||..|:     |....|.:..:..|...
Mouse  1107 ----------PNNAIKREREKTVP----KILSKSETASSRHTTVKEVQSEKKVSPTEVALESLHK 1157

  Fly  1221 SSSSSSSSHSGKGES---------RGEEANGENADEKC-------SKKKEMLLNIDNLSNISSTE 1269
            ::::..:...|.||.         .|.:.||...:||.       :||:....|..|.:::..|.
Mouse  1158 ATANKENELCGDGERPKNADTSKLPGGQQNGSLRNEKAIASLQELTKKQATPSNNKNATSVGGTV 1222

  Fly  1270 DEEWLKAAGSEDAVLPMLAIDSQPGQLVSQDGEVRYPIRNWLTPSKEQAQETD-----TSGE--- 1326
            .::  |...|:.|       .|..|..:.||..:..|        ..::.:||     |.|.   
Mouse  1223 KDQ--KQEQSKPA-------SSLIGAEILQDVPIHSP--------ANRSADTDLPVPRTPGSGAG 1270

  Fly  1327 QQTKPTPPKPVAAPV--------PPPPLPLTPPAAPPPPPPPPPEADDPSSVALPTASTSRQEHQ 1383
            ::.|..|...:.||.        ..|.:.:.|..|..|...|..|....:||::..       |.
Mouse  1271 EKHKEEPSDSMKAPASRRCGEEGSMPRVMIPPVTADLPACSPASETGSENSVSMAA-------HT 1328

  Fly  1384 RQQLNEKRQRVVAKFKEQPQPIKGQGRKTANKKLTAMRENAKL--ANPSSQKSPKNRKHIE-PLK 1445
            ...|:   :..:|:....|.....|..:|:::..|..|:..:|  ...:|:.|.||..:.. |:|
Mouse  1329 LMILS---RAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSGKNLANSSVPMK 1390

  Fly  1446 TKAAKKQIEPN 1456
            .|..||:..|:
Mouse  1391 KKKIKKKKLPS 1401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mxcNP_572548.1 PTZ00108 <1414..1643 CDD:240271 13/46 (28%)
NpatNP_001074621.1 Interaction with MIZF. /evidence=ECO:0000250 1..319 78/362 (22%)
Required for activation of histone gene transcription and interaction with MIZF. /evidence=ECO:0000250 5..25 13/19 (68%)
Required for activation of histone gene transcription and interaction with MIZF. /evidence=ECO:0000250 121..145 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 179..236 8/56 (14%)
Mediates transcriptional activation. /evidence=ECO:0000250 263..339 22/77 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..612 25/157 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 625..670 13/56 (23%)
Required for acceleration of G1 phase. /evidence=ECO:0000250 628..652 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 696..727 8/35 (23%)
NPAT_C 754..1420 CDD:434876 138/742 (19%)
Required for acceleration of G1 phase. /evidence=ECO:0000250 822..847 7/29 (24%)
Required for acceleration of G1 phase. /evidence=ECO:0000250 1033..1048 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1190 21/132 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1234 8/40 (20%)
Required for acceleration of G1 phase. /evidence=ECO:0000250 1223..1247 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1297 9/55 (16%)
Required for acceleration of G1 phase. /evidence=ECO:0000250 1319..1342 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1400 14/51 (27%)

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