Protein Alignment CG31321 and Slc46a3

DIOPT Version :10

• Sequence 1: NP_731899.1
• Gene: CG31321 / 318681
• FlyBaseID: FBgn0051321
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_082148.1
• Gene: Slc46a3 / 71706
• MGIID: 1918956
• Length: 460
• Species: Mus musculus
• Alignment Length: 576
• Identity: 122/576 - (21%)
• Similarity: 208/576 - (36%)
• Gaps: 162/576 - (28%)

  Fly    39 IEPFFFFYFMASVFNAVAMQ-NFPLDKACRVNLGYNKIVCDT---MLDKSELGIECDD------F 93
            |||       |.:.||.||. ..||    .....|.:|..:|   ....:..|.|||.      |
Mouse     6 IEP-------AILLNAFAMTLTIPL----TAQYVYRRIWEETGNYTFASNSNGSECDQNKSSSIF 59

  Fly    94 DFENTTQGATPDLADLVIGATGFNYTVCKAELEAQILAADVSGKRAPMAAIFPLIV---LLFAGG 155
            .|....|..          |:.||..|                   .|:|:.|.:|   :|.|.
Mouse    60 AFREEVQKK----------ASLFNLQV-------------------EMSALIPGLVSTFMLLAS- 94

  Fly   156 WADRYNKRKPCMIMPIIGEALSFTCQIISSIFFESLPMEFGAYCEAIVPALFGGLTFCLMAIYSY 220
             :|.:.::.| |::..:|...:.|...:.|.|  .||::. ......:.||||..|....|.::|
Mouse    95 -SDNHGRKLP-MVLSSLGSLGTNTWLCMMSYF--DLPLQL-LIASTFIGALFGNYTTFWGACFAY 154

  Fly   221 ITIATPE-EDRVFRFGIFAMF---VTGVPFIGQPISGVLFTTLGYTWSFASAIVFQLIAIFYIIF 281
            |.....| :.|:.|..|....   |||:..:.   ||.....||:.||:....:..::.:.||:|
Mouse   155 IVDQQKEYKHRIIRIAILDFMLGVVTGLTGLS---SGYFIRELGFVWSYFITAMVLIVNLAYILF 216

  Fly   282 FIKEVKTTPTTSTTANEPPPLPTSLPPKQQGADNMAYETTNLDELQGNKNVNFQLTPQMEPKVEV 346
            |:.:                     |.|:..:     :...:..::.
Mouse   217 FLND---------------------PIKESSS-----QIVTMSCIES------------------ 237

  Fly   347 VPPKRSLLKELFDPTLVLDCIRFPLVKRPNNGRM----LLILLLCAYF---LTVGPTSGENDYWY 404
                   ||:||..|       :.|.|..::.|.    |||..|..||   :.:.|.
Mouse   238 -------LKDLFYRT-------YMLFKNGSSKRQALLCLLIFTLVIYFFVIIGISPI-------- 280

  Fly   405 RFTLKK----LAWNGNDFSIYLTLSS---GAALVGTFIGTAILSKLLKVSDSMIGMLSALSIVCS 462
             |||.:    |.||    .:|:...|   ..:.:.:|:|..:.|..||  |..|..:...:.:..
Mouse   281 -FTLYELGPPLCWN----EVYIGYGSALGSVSFLSSFLGIWLFSYCLK--DIHIAYIGIFTTMVG 338

  Fly   463 RVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQFIFPPIF 527
            ..|.||:.:|...::..:..:|..:.:..::::.|.:|...|...:::.....|.:|.......:
Mouse   339 MTLAAFTRTTLMMFLVRIPFIFTIMPLSVLRSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAY 403

  Fly   528 SEIYKSTVDSFPGAIWLFGE-IFYIPNVLVFVV--------CYFLLRRRKANEEKS 574
            |.||.:||..:||.|:|... :..:|.:.:..|        .|.||...:.:|..|
Mouse   404 SGIYSATVAWYPGFIFLLSAGLLVLPAISLCCVKSIGWEEGSYTLLVHEEPSEHTS 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31321	NP_731899.1	MFS_SLC46	36..561	CDD:340944	117/561 (21%)
Slc46a3	NP_082148.1	MFS	3..437	CDD:475125	116/552 (21%)
		Tyrosine-based lysosomal-sorting motif. /evidence=ECO:0000250|UniProtKB:Q7Z3Q1	446..449		1/2 (50%)