DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31321 and CG8008

DIOPT Version :9

Sequence 1:	NP_731899.1	Gene:	CG31321 / 318681	FlyBaseID:	FBgn0051321	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	143/586 - (24%)
Similarity:	247/586 - (42%)	Gaps:	99/586 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FQKLWRYRHYLVIEPFFFFYFMASVFNAVAMQNFPLDKACRVNLGYNKIVCDTMLDKSELGIECD 91
            ::|::|   ...|||..|....:...:....:|..:.:.|.|...||:             .:|.
  Fly    19 WEKVFR---MFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNE-------------SDCK 67

  Fly    92 DFDFENTTQGATPDLADLVIGATGFNYTVCKAELEAQILAADVSGKRAPMAAIFPLIVLLFAGGW 156
            ..|.:|         |...|.|         .|.|.|...|::...|..:.:|.|....||.|.|
  Fly    68 QLDVKN---------ASAEINA---------IETELQPYVANLFLARTLLESIVPAFCGLFIGSW 114

  Fly   157 ADRYNKRKPCMIMPIIGEALSF-----TCQIISSIFFESLPMEFGAYCEAIVP-ALFGGLTFCLM 215
            :|.|. |||.:|:.:||.:.||     .|::  |.::...|.   .|..|.|| :|.||.....:
  Fly   115 SDHYG-RKPLLIVSMIGFSASFLMMAAICEL--SSYYVVNPW---WYIMAAVPHSLLGGNCVFSV 173

  Fly   216 AIYSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGY-------TWSFASAIVFQL 273
            |.:.:|:..|..:.|.:|.    :|:..:.|||. .||.|.::..|       |...:..||  .
  Fly   174 AAFCFISDITDCKSRPYRM----IFMESLFFIGL-TSGSLLSSFVYAAVGSAATIGISGCIV--T 231

  Fly   274 IAIFYIIFFI-------KEVKTTPTTSTTAN-EPPPLPTSLP--PKQQGADNMAYE--TTNLDEL 326
            .|..:||||:       ||.:|  ..:.||| |...:.:.:|  ......|.:|.:  ...:::.
  Fly   232 FATLFIIFFVPESLHFHKEQET--KNAITANVEKECIDSKVPITACDLQLDRVAIDCPPNFMNDE 294

  Fly   327 QGNKNVNFQL----TPQME-------PKVEVVPPKRSLLKE-----------LFDPTLVLDCIRF 369
            :..|:...:|    ||.|.       ..||.:|.|....|.           ||....:.|.|..
  Fly   295 EPGKDKRMELPTPATPAMSFDDDLLAKYVERLPQKAEERKRQEAEEQAKKAGLFSMVHIRDMIST 359

  Fly   370 PLVKRPNNGRMLLILLLCAYFLTVGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTF 434
            ...:|.::.|.::.|:..|.||::....|.....|.|..:|..|...|::.:.|:|....::|..
  Fly   360 CFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYLFVREKFHWTVRDYTFFETVSHLVPMIGAL 424

  Fly   435 IGTAILSKLLKVSDSMIGMLSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSI 499
            ||..||.|:.::|...:.:|:..|.:.:.:...|::.....|::..:.:|.|:.....:||.|:|
  Fly   425 IGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFATMPWHMYLSVTLGVFRSISGPMCRTIVSNI 489

  Fly   500 VAGDELSKMYSIFGISEPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIFYIPNVLVFVVCYFLL 564
            |...:|.|::||..:.:..|.|:..|:::.|||.::.::||.........|:   |.||...::|
  Fly   490 VPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSLTTYPGLFNFVSSFLYL---LSFVFIGYVL 551

  Fly   565 R 565
            |
  Fly   552 R 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31321	NP_731899.1	MFS	141..>271	CDD:119392	41/142 (29%)
		MFS_1	143..>271	CDD:284993	41/140 (29%)
		MFS	<379..559	CDD:119392	46/179 (26%)
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	119/463 (26%)
		MFS_1	101..>261	CDD:284993	52/174 (30%)
		MFS_1	375..>558	CDD:284993	47/181 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458950
Domainoid	1	1.000	97	1.000	Domainoid score	I7096
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7720
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800