DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31321 and AgaP_AGAP005319

DIOPT Version :9

Sequence 1:	NP_731899.1	Gene:	CG31321 / 318681	FlyBaseID:	FBgn0051321	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_315333.4	Gene:	AgaP_AGAP005319 / 1276033	VectorBaseID:	AGAP005319	Length:	532	Species:	Anopheles gambiae

Alignment Length:	572	Identity:	129/572 - (22%)
Similarity:	235/572 - (41%)	Gaps:	103/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRSSADAAGNGSGAVDAEPKLNYFQKLWRYRHYLVIEPFFFFYFMASVFNAVAMQNFPLDKACRV 68
            |..||.:..:..|.|..    :...:|..:...||:     ..|..|| :.|.:.:..:.::|.|
Mosquito    50 PPPSASSCSSDGGKVST----SVTDRLCTFEPILVL-----LCFGLSV-SGVVLADQIIYQSCVV 104

  Fly    69 NLGYNKIVCDTMLDKSELGIECDDFDFENTTQGATPDLADLVIGATGFNYTVCKAELEAQILAAD 133
            .|||::.:|      ::||           |:..:.|:|.|              |...|..||.
Mosquito   105 TLGYDRALC------AQLG-----------TRSNSSDVAQL--------------ETIVQPYAAK 138

  Fly   134 VSGKRAPMAAIFPLIVLLFAGGWADRYNKRKPCMIMPIIGEALSFTCQIISSIFFESLPMEFGAY 198
            ::.....:.::.|.:..||.|.|:|:|. |||.||:|.:|...::....|.|:..:...::...|
Mosquito   139 ITMVNTILMSVLPALCALFMGPWSDKYG-RKPAMIVPAVGFITTYVMIGILSLLSKRFLVDPWCY 202

  Fly   199 CEAIVP-ALFGGLTFCLMAIYSYITIATPEEDRVFRFGIFAMFVTGVPFIGQPISGVLFTTLGYT 262
            ..|.:| |:.||.|..:.||:||:|..|.|.:|..|.||.........|:     |:|.::....
Mosquito   203 VVAHIPAAILGGSTVLMAAIFSYLTDTTSEANRTVRIGILQACTMLGAFV-----GLLSSSFILQ 262

  Fly   263 WSFASAIVFQLIAIFYIIFFIKEVKTTPTTSTTANEPPPLPTSLPPKQQGADNMAYETTNLDELQ 327
            |:....           :||:    :..|.|.:.                    |:
Mosquito   263 WTNVPT-----------MFFL----SAGTVSASC--------------------AF--------- 283

  Fly   328 GNKNVNFQLTPQMEPKVEVVPPKRSLLKELFDPTLVLDCIRFPLVKRPNNGRMLLILLLCAYFLT 392
                :.|.|...::|...:|   ...::|:|..:.:.:.:.....||....|.::.|.:....:|
Mosquito   284 ----LYFCLEDSIKPDASMV---HRQVREIFRLSHLAELLTTFFKKRSFYDRGIVWLTISIGIVT 341

  Fly   393 V-GPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFIGTAILSKLLKVSDSMIGMLSA 456
            | |  :|....::.:|.::..|...:|:|:..:...:.:.|..||.::|..|||:.|..:.:||.
Mosquito   342 VLG--AGGGTVFFLYTRRQFGWTIQEFTIWQAVELLSIVAGNVIGISVLKTLLKLPDIWLALLSV 404

  Fly   457 LSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIAIKTIGSSIVAGDELSKMYSIFGISEPIAQF 521
            |:.....::...:......::|..:....:....|:..|.|:|:...|::|.|||..........
Mosquito   405 LNYALDALIKGLARQGWELFLATGITPLKATEGAALMAICSAIIPSSEIAKFYSIAMAMTNTVSL 469

  Fly   522 IFPPIFSEIYKSTVDSFPGAI-WLFGEIFYIPNVLVFVVCYFLLRRRKANEE 572
            ...|:|:.||.|||.:.|... ::...||.:..|||.|:...|.:||||..:
Mosquito   470 ASAPLFTYIYNSTVATSPQVFNFVSSGIFSLNVVLVGVIAVLLRKRRKAQAD 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31321	NP_731899.1	MFS	141..>271	CDD:119392	38/130 (29%)
		MFS_1	143..>271	CDD:284993	38/128 (30%)
		MFS	<379..559	CDD:119392	44/181 (24%)
AgaP_AGAP005319	XP_315333.4	MFS_1	146..465	CDD:284993	82/377 (22%)
AgaP_AGAP005319	XP_315333.4	MFS	146..>288	CDD:119392	44/195 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820