Protein Alignment Wsck and Fgfr3

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: XP_006251454.1
• Gene: Fgfr3 / 84489
• RGDID: 620714
• Length: 803
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 130/620 - (20%)
• Similarity: 239/620 - (38%)
• Gaps: 156/620 - (25%)

  Fly   263 RTVTIEL------SPIRNDNGPLSKLLVIVEYVDNALSQPFDAQLLGSW--------QQAQQDGV 313
            :|.|:::      .||.....|.::..|:...|:.......|||....|        .:...||.
  Rat   233 QTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 297

  Fly   314 PY------YIAAELDYDRPEDNRTRRFVVG--DGKRY-GRFTNKPLDQPDAHVHISLGLVSTLEG 369
            ||      :|:..::    .|.|.|...|.  ||..| .|.||                   ..|
  Rat   298 PYVTVLKSWISENVE----ADARLRLANVSERDGGEYLCRATN-------------------FIG 339

  Fly   370 VTKTMYSRGTH-----DQHVTSLDDFSYATFEKGQ--SSVVALAVTCVIFGSCLLLSLIAYFYLR 427
            |.:..:....|     ::.:..:|       |.|.  :.|::..|...:|  .|:::.:....||
  Rat   340 VAEKAFWLRVHGPQAAEEELMEVD-------EAGSVYAGVLSYGVGFFLF--ILVVAAVTLCRLR 395

  Fly   428 YKTCRGRRLTGGNTHEMT---LQTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERIPRN 489
            ....:|  |.....|:::   |:...:..|:|..:..:.||        .::.:|..|...:..|
  Rat   396 SPPKKG--LGSPTVHKVSRFPLKRQQVSLESNSSMNSNTPL--------VRIARLSSGEGPVLAN 450

  Fly   490 A---------------LRLNVNDVIGDGRFGEIITGK---VSTNDFARDCTLHVLCL-DDLNGTT 535
            .               .||.:...:|:|.||:::..:   :..:..|:..|:.|..| ||.....
  Rat   451 VSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKD 515

  Fly   536 QAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR-----------LM 589
            .:.|:.|:..:..:.:.:::::..|........|::.|.......|:.:.:|           ..
  Rat   516 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACR 580

  Fly   590 APSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIA 654
            .|..:||...   ::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||      :|
  Rat   581 LPEEQLTCKD---LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFG------LA 636

  Fly   655 RQQPDHN--------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVAS 705
            |..  ||              :|:|||.| ....::.:|||||...:.||...|||:||.....
  Rat   637 RDV--HNLDYYKKTTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV- 697

  Fly   706 NQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRH------A 764
             ::|.:.::...|..:||....|||.::..||...||:|.:.:.:...:.:::|....      :
  Rat   698 -EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLS 761

  Fly   765 LSFDRVA-GGLDT----------------LPPYLP 782
            :.|::.: ||.||                |||..|
  Rat   762 VPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPP 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348
		fn3	130..222	CDD:394996
		PTKc	497..750	CDD:270623	69/281 (25%)
Fgfr3	XP_006251454.1	IG_like	52..123	CDD:214653
		Ig strand B	55..59	CDD:409358
		Ig strand C	69..73	CDD:409358
		Ig strand E	91..94	CDD:409358
		Ig strand F	104..108	CDD:409358
		IgI_2_FGFR	145..239	CDD:409443	2/5 (40%)
		Ig strand A	145..148	CDD:409443
		Ig strand A'	156..161	CDD:409443
		Ig strand B	165..173	CDD:409443
		Ig strand C	179..184	CDD:409443
		Ig strand C'	187..189	CDD:409443
		Ig strand D	198..201	CDD:409443
		Ig strand E	205..210	CDD:409443
		Ig strand F	219..226	CDD:409443
		Ig strand G	229..239	CDD:409443	2/5 (40%)
		IgI_3_FGFR	247..347	CDD:409363	26/122 (21%)
		Ig strand A	247..250	CDD:409363	2/2 (100%)
		Ig strand A'	254..258	CDD:409363	1/3 (33%)
		Ig strand B	266..273	CDD:409363	0/6 (0%)
		Ig strand C	277..284	CDD:409363	1/6 (17%)
		Ig strand D	299..304	CDD:409363	1/4 (25%)
		Ig strand E	315..320	CDD:409363	2/4 (50%)
		Ig strand F	328..336	CDD:409363	2/7 (29%)
		Ig strand G	339..347	CDD:409363	2/7 (29%)
		PTKc_FGFR3	456..789	CDD:173652	77/346 (22%)