Protein Alignment Wsck and TIE1

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_005415.1
• Gene: TIE1 / 7075
• HGNCID: 11809
• Length: 1138
• Species: Homo sapiens
• Alignment Length: 755
• Identity: 173/755 - (22%)
• Similarity: 287/755 - (38%)
• Gaps: 197/755 - (26%)

  Fly    75 HYAVLASEKCFCANVLEPQEQQDEQLCNTRCLANKAQYC----------GGVGVHSYYSTILTKQ 129
            ||....|...:...|::|.|  :..|.|.|   .|..|.          ||.|.....:.:.|..
Human   483 HYRPQDSTMDWSTIVVDPSE--NVTLMNLR---PKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDC 542

  Fly   130 PGP--------HHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQLL-DNFLIK------- 178
            |.|        .|:..:::    |.:||:.             .::|..|: |.||::
Human   543 PEPLLQPWLEGWHVEGTDR----LRVSWSL-------------PLVPGPLVGDGFLLRLWDGTRG 590

  Fly   179 AQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQSEC---GQASIE 240
            .:..:..||    ||....:        ||.|.|.|.|.:.|:..         .|   |.||..
Human   591 QERRENVSS----PQARTAL--------LTGLTPGTHYQLDVQLY---------HCTLLGPASPP 634

  Fly   241 ATTEVGLPSPVPAQPKIL---SRTDRTVTI-----ELSPIRNDNGPLSKLLVIVEYVDNALSQPF 297
            |  .|.||...|..|:.|   :.:|..:.:     |..|     ||:||.:|.|:....|
Human   635 A--HVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALP-----GPISKYVVEVQVAGGA----- 687

  Fly   298 DAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGKRY-----------GRFTNKPLD 351
                          |.|.:|    |.||||:..|....:....||           |.::|...:
Human   688 --------------GDPLWI----DVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEE 734

  Fly   352 QPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSSVVALAVTCVIFGSCL 416
            .       :||.....||..:.  ||..                |:|....:.|||...:..:||
Human   735 S-------TLGNGLQAEGPVQE--SRAA----------------EEGLDQQLILAVVGSVSATCL 774

  Fly   417 --LLSLIAYFYLRYKTCRGRRLT----GGNTHEMTLQTPIIERENNGYLVEDDPLPHSPENFKQQ 475
              |.:|:....:| ::|..||.|    .|:..|..||.      ::|.|.    |...|:...:.
Human   775 TILAALLTLVCIR-RSCLHRRRTFTYQSGSGEETILQF------SSGTLT----LTRRPKLQPEP 828

  Fly   476 LQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGTTQAQLL 540
            |...|..:|.|       ...|:||:|.||::|...:..:....:..:.:| .:..:........
Human   829 LSYPVLEWEDI-------TFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKML-KEYASENDHRDFA 885

  Fly   541 RELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPSPRL-------TS 597
            .||..|.:|....::::..|...:..:.|:..|.... :|...|.:||::...|..       ::
Human   886 GELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTAST 950

  Fly   598 LSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDH-- 660
            ||.:.:|::..:.|:.|.|||..|.:||.|.:.:|.|..:...|::.||      ::|.:..:
Human   951 LSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFG------LSRGEEVYVK 1009

  Fly   661 -------NRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVR 718
                   .||:|.|.|.:. .::|:|||||...:.||..:||||||.....:  :|.|.:....|
Human  1010 KTMGRLPVRWMAIESLNYS-VYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA--ELYEKLPQGYR 1071

  Fly   719 PAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLM 758
            ..||.....::|:|:..||:..|.||.....:|..:.:::
Human  1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348	11/49 (22%)
		fn3	130..222	CDD:394996	22/107 (21%)
		PTKc	497..750	CDD:270623	69/269 (26%)
TIE1	NP_005415.1	ig	129..210	CDD:395002
		EGF_CA	227..256	CDD:238011
		EGF_2	321..344	CDD:400365
		Ig	350..441	CDD:472250
		Ig strand B	368..372	CDD:409556
		Ig strand C	384..388	CDD:409556
		Ig strand E	409..413	CDD:409556
		Ig strand F	423..428	CDD:409556
		Ig strand G	436..439	CDD:409556
		fn3	452..536	CDD:394996	14/57 (25%)
		fn3	548..632	CDD:394996	22/121 (18%)
		FN3	644..736	CDD:238020	26/126 (21%)
		PTKc_Tie1	836..1132	CDD:270671	72/293 (25%)