DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and btl

DIOPT Version :10

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:916 Identity:182/916 - (19%)
Similarity:322/916 - (35%) Gaps:280/916 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 DEQLCNTRCLANKAQYCGGVG---VHSYYSTILTKQP---GPHHLRI--------SNKTE----- 142
            |.:..|...|.|..|..||.|   :..:..|:...||   |.:|..:        ||.|:     
  Fly   170 DAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVIS 234

  Fly   143 --NSLTLSWNAYEARKLLLAG---GAEAVLPNQLL------------DNFLIKAQVLKTYSSLPA 190
              :::.:....|.....:..|   ..|.:|.:..|            ||.....|.|:..|.|| 
  Fly   235 RKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLP- 298

  Fly   191 FPQPEFMVQSTETQFELTDLHPATLYNISVR----AMC-KDAQVGQ----------SECGQASIE 240
                   |..|.....:.:.....|.|:.:.    .:| .:.|||:          |.....::.
  Fly   299 -------VDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVR 356

  Fly   241 ATTEVGLPSPVPAQP--------------------------KILSRTDRTV---TIELS-PI--- 272
            .||...:.||:|...                          |.|.|...::   |:.|: |:   
  Fly   357 TTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGK 421

  Fly   273 -----RNDNGPLSKLLVIVEYV--------------DNALSQPFDAQLLGSWQQAQQDGVPYYIA 318
                 ..|..||::.|.:  ||              |:.|   ::.::..:|.           .
  Fly   422 ANITWTKDKKPLNRELGV--YVQKNWTLRFVEATSEDSGL---YNCKVCNAWG-----------C 470

  Fly   319 AELDYDRPEDNRTRR---FVVGDG---KRYGRFTNKPLDQPDAHVHISLGLV----STLEGV--- 370
            .:.|:....::|||.   .||...   |..|....|.....|.|..:|...|    ::|:|:   
  Fly   471 IQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSV 535

  Fly   371 -TKTMYSRGTHDQHVTSLDDFSY---------ATFEKGQSS---------------VVAL----- 405
             .:.:....|:|..|.:|.:.::         |:...|:|:               :.||     
  Fly   536 EIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHP 600

  Fly   406 ------AVTCV---IFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMT---------------- 445
                  |:|.|   :.||    :.|.:...|.:..:..:|.....|:.|                
  Fly   601 LGFTLAAITIVALFLLGS----AFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGC 661

  Fly   446 ----LQTPIIERENNGYLVE------DDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIG 500
                ||.|:|..|.....|.      .||    .:.|.:....|...:| |||.  :|::..::|
  Fly   662 SSGDLQMPVIRIEKQRTTVSTTGTGGTDP----AQGFNEYEFPLDSNWE-IPRQ--QLSLGSILG 719

  Fly   501 DGRFGEII----TGKVSTNDFARDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGV 561
            :|.||.::    .|...:...|.......:..::...|..|.|:||:..:..:.:..::::..|.
  Fly   720 EGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGC 784

  Fly   562 SASPDWFYLIFE-QQRMSLKRKLVESRLMAPSPRLTS--------------LSEQLVLQWIYELA 611
            .:.....::|.| ....:||..|.::|..||..|..|              |.|:.:.::.:::|
  Fly   785 CSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIA 849

  Fly   612 SAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN------------RWL 664
            ..|.||:|.:.:||.|.:.:|.|:..:.:|::.||      :||...|..            :|:
  Fly   850 RGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFG------LARDIQDTEYYRKNTNGRLPIKWM 908

  Fly   665 APEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPAYVYGDL 729
            |||.|:.:.:.| :|||||...:.||....|..||.: :.|.::|...:....|..:||....::
  Fly   909 APESLQEKKYDS-QSDVWSYGVLLWEIMTYGDQPYPH-ILSAEELYSYLITGQRMEKPAKCSLNI 971

  Fly   730 YQLLLNCWQLEPSERSSCEDVAFG---------VRQLMTSPRHALSFDRVAGGLDTLPPYLPQLE 785
            |.::..||..|     ||....|.         ::|..::|..|.           |...:|.||
  Fly   972 YVVMRQCWHFE-----SCARPTFAELVESFDGILQQASSNPNDAY-----------LDLSMPMLE 1020

  Fly   786 AVATMG 791
            ...:.|
  Fly  1021 TPPSSG 1026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:460348 5/17 (29%)
fn3 130..222 CDD:394996 22/128 (17%)
PTKc 497..750 CDD:270623 67/283 (24%)
btlNP_729956.1 Ig 143..215 CDD:472250 13/44 (30%)
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570 1/3 (33%)
Ig strand E 197..201 CDD:409570 0/3 (0%)
Ig strand F 211..215 CDD:409570 1/3 (33%)
Ig_3 247..333 CDD:464046 16/93 (17%)
Ig 398..479 CDD:472250 16/96 (17%)
Ig strand B 412..416 CDD:409393 1/3 (33%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 0/3 (0%)
Ig strand F 459..464 CDD:409393 1/7 (14%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 16/90 (18%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 1/3 (33%)
Ig strand E 549..553 CDD:409444 1/3 (33%)
Ig strand F 563..568 CDD:409444 0/4 (0%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 74/315 (23%)
Blue background indicates that the domain is not in the aligned region.

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