Protein Alignment Wsck and ret

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_858048.2
• Gene: ret / 30512
• ZFINID: ZDB-GENE-980526-307
• Length: 1106
• Species: Danio rerio
• Alignment Length: 734
• Identity: 171/734 - (23%)
• Similarity: 278/734 - (37%)
• Gaps: 196/734 - (26%)

  Fly   191 FPQPEFMVQSTETQFELTDLH-PATLYNISVRAMCKDAQVGQSECGQASIEATTEV-GLPSPVPA 253
            ||.||..|.   ..|.:|.|. |....|::............|:.|:..:|...:. |:  .|..
Zfish   366 FPGPEGTVL---LHFNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGI--DVTY 425

  Fly   254 QPKILSRTDRTVTIE---------LSPIRNDN-GPL----SKLL-----------VIVEYVDNAL 293
            |.:|:   ||.:|.|         |:...||| |.|    :|:|           ||.:...|.|
Zfish   426 QLEIV---DRNITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKL 487

  Fly   294 SQPFDAQLLGSWQQAQQDGV----PYYIAAELDYDRPEDNRTRRFVVGDGK---RYGRFTNKPLD 351
            ..  ..||..|: |.:.|.:    |.:.|......|.:...||......|:   |.||  :|.:.
Zfish   488 QA--KTQLTVSF-QGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGR--DKGIS 547

  Fly   352 QPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYAT---FEKGQSSVVALAVTCVIF- 412
            :..:....:||  :..:|....:.|:..   .:...|..|.|.   :|:....:.|...||..|
Zfish   548 KRYSTCSPNLG--TCPDGYCDAIESKNI---SICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFE 607

  Fly   413 GSC-----------------------LLLSLI------AYFYLRYKTCRGRRLTGGNTHEMTLQT 448
            |.|                       ::||.|      :||..||             |:.|.:.
Zfish   608 GKCFCERDEPEDDICNDMCKTVIATGIILSFIVSVLLSSYFIHRY-------------HKTTPKP 659

  Fly   449 PI------IERENNGYLVEDDPLPHSPENFKQQLQQLVEGYERI-------------PRNALRLN 494
            ||      ..|....|     |:.:|..|.::.....:|....|             ||..|.|
Zfish   660 PIASAEMTFRRPAQSY-----PISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVL- 718

  Fly   495 VNDVIGDGRFGEII-------TGKVSTNDFARDCTLHVLCL-DDLNGTTQAQLLRELRQLSQLKR 551
             ...:|:|.||:::       .||      |...|:.|..| ::.:.:....||.|...|.|: .
Zfish   719 -GKTLGEGEFGKVVKATAFRLKGK------AGYTTVAVKMLKENASHSELRDLLSEFTLLKQV-N 775

  Fly   552 QEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPS---------------PRLTSLSE 600
            ..|::..||..:.....|||.|..:. ||:..|.|||.:.||               |...:|:.
Zfish   776 HPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTM 840

  Fly   601 QLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN---- 661
            ..::.:.::::..|.||:..::|||.|.:.:|.|....|:|:|.||      ::|...:.:
Zfish   841 GDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFG------LSRDVYEEDSYVK 899

  Fly   662 --------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVR 718
                    :|:|.|.| ..|.::|:|||||...:.||...|||.||..  .:.::|...::...|
Zfish   900 RSKGRIPVKWMAIESL-FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG--IAPERLFNLLKTGYR 961

  Fly   719 PAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLM-----------TSPRHALSFDRVAG 772
            ..:|.....::|.|:|.||:.|..:|.:..|::..:.::|           ::|..||.:|....
Zfish   962 MEKPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLS 1026

  Fly   773 GLDT---------LPPYLP 782
            ..||         ||..||
Zfish  1027 EEDTPLVDCSNAPLPRTLP 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348
		fn3	130..222	CDD:394996	10/31 (32%)
		PTKc	497..750	CDD:270623	75/288 (26%)
ret	NP_858048.2	RET_CLD1	23..140	CDD:465485
		CA	186..256	CDD:214520
		RET_CLD3	251..364	CDD:465516
		RET_CLD4	388..499	CDD:465517	27/118 (23%)
		PTKc_RET	715..1004	CDD:173631	79/306 (26%)