Protein Alignment Wsck and Ret

DIOPT Version :10

• Sequence 1: NP_733018.1
• Gene: Wsck / 318600
• FlyBaseID: FBgn0046685
• Length: 791
• Species: Drosophila melanogaster
• Sequence 2: NP_036775.2
• Gene: Ret / 24716
• RGDID: 3556
• Length: 1115
• Species: Rattus norvegicus
• Alignment Length: 966
• Identity: 196/966 - (20%)
• Similarity: 345/966 - (35%)
• Gaps: 286/966 - (29%)

  Fly    20 LVAMCLGLPLGAAVPQEAPAYYYVGCYTARTDLLHE------SVYAK---TPQTCIE-------- 67
            |:.:.|.:.||:...:|... ::.||.......:::      |..|:   ||:|.:.
  Rat   118 LLTVFLQVFLGSTAQREGEC-HWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRP 181

  Fly    68 --------------ICEHQGHHYAVLASE----KC--FCANVLE----PQEQQDEQLCNTRCL-- 106
                          :|.:....|.:|..:    :|  .|..|..    .:|.|::.:....|.
  Rat   182 PGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVA 246

  Fly   107 ---ANKAQ------------------YCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWN 150
               |||.:                  :.||||..|.......|             |.::..:..
  Rat   247 GPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRK-------------EGTVVATLQ 298

  Fly   151 AYEA-------------RKLLLAGGAEAV-------LPNQLL---DNFLIKAQ------VLKTYS 186
            .::|             ...||:|.:.|.       .||:.|   :|..::|.      ||....
  Rat   299 VFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSL 363

  Fly   187 SLPAFPQPEFMVQSTETQFE-----LTDLH------PATL-----YNISV-RAMCKDAQVGQ--- 231
            |:......:.:|...::.|:     :..||      |.||     |:..| |...:.||:|:
  Rat   364 SISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCV 428

  Fly   232 SECGQASIEATTEVGLPSPVPAQPK---------ILSRTDRTVTIELSPIRNDNGPL-----SKL 282
            ..|.:.|       |:......||.         :.|..|.:.|:.:    ||...|     ::|
  Rat   429 ENCQEFS-------GVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYV----NDTEALRRPECTEL 482

  Fly   283 LVIVEYVDNALSQPFDAQLL----GSWQQAQQDGVPYYIAAELDYDRPE-------DNRTRR--F 334
            ...|...|....:...|.|:    |:: .|::.|.|...|  ::..|||       .:.|.|  :
  Rat   483 QYTVVATDRQTRRQTQASLVVTVEGTY-IAEEVGCPKSCA--VNKRRPECEECGGLGSPTGRCEW 544

  Fly   335 VVGDGKRYGR--FTNKPLDQ--PDAHV------HISLGLVSTLEGVTKTMYSRGTHDQHVTS--- 386
            ..||||...|  .|..|..:  ||.|.      .|::.....|.|.....:.||.. |.:.:
  Rat   545 RQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGER-QGIKAGYG 608

  Fly   387 ----LDDFSYATFEKGQS------SVVALAVTCVIFGSCLLLSLIAYFYL-RYKTCRGRRLTGGN 440
                ..|......|...|      .:....:|..:..|.::..|::.|.: ||..         :
  Rat   609 ICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHK---------H 664

  Fly   441 TH-------EMTL----------------QTPIIERENNGYLVEDDPLPHSPENFKQQLQQLVEG 482
            .|       |||.                :.|.::...|...|:...:|..|:
  Rat   665 AHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPK------------ 717

  Fly   483 YERIPRNALRLNVNDVIGDGRFGEIITGKV-STNDFARDCTLHVLCLDDLNGTTQAQLLRELRQL 546
            :| .||..|.|  ...:|:|.||:::.... .....|...|:.|..|.:  ..:|::|...|.:.
  Rat   718 WE-FPRKNLVL--GKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKE--NASQSELRDLLSEF 777

  Fly   547 SQLKR--QEHLLDFYGVSASPDWFYLIFEQQRM-SLKRKLVESRLMAPS---------------- 592
            :.||:  ..|::..||..:......||.|..:. ||:..|.:||.:.|:
  Rat   778 NLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHP 842

  Fly   593 -PRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQ 656
             .|:.::.:.:...|  :::..|.||:..::|||.|.:.::.|....|:|:|.||      ::|.
  Rat   843 DERVLTMGDLISFAW--QISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFG------LSRD 899

  Fly   657 QPDHN------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQL 709
            ..:.:            :|:|.|.| ..|.::|:|||||...:.||...|||.||..  ...::|
  Rat   900 VYEEDSYVKKSKGRIPVKWMAIESL-FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG--IPPERL 961

  Fly   710 LEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQLMTSPRHAL 765
            ...::...|..:|.....::|:|:|.||:.||.:|....|::..:.::|...|..|
  Rat   962 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYL 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wsck	NP_733018.1	WSC	42..115	CDD:460348	19/136 (14%)
		fn3	130..222	CDD:394996	23/137 (17%)
		PTKc	497..750	CDD:270623	70/285 (25%)
Ret	NP_036775.2	RET_CLD1	29..154	CDD:465485	7/36 (19%)
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949	29..153		7/35 (20%)
		Cadherin	173..248	CDD:394985	9/74 (12%)
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949	266..380		21/126 (17%)
		RET_CLD3	266..380	CDD:465516	21/126 (17%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949	406..507		22/111 (20%)
		RET_CLD4	408..507	CDD:465517	22/109 (20%)
		PTKc_RET	724..1013	CDD:173631	74/303 (24%)