DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wsck and FGFR1

DIOPT Version :10

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:711 Identity:140/711 - (19%)
Similarity:274/711 - (38%) Gaps:173/711 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 PNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISVRAMCKDAQVGQS 232
            ||.:...:....::.|...::||....:|...|:.|.      :|...:..:.:....|.::|  
Human   179 PNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP------NPTLRWLKNGKEFKPDHRIG-- 235

  Fly   233 ECGQASIEATTEVGLPSPVPAQPKILSRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPF 297
              |.....||..:.:.|.||:     .:.:.|..:|     |:.|.::....: :.|:.:..:|.
Human   236 --GYKVRYATWSIIMDSVVPS-----DKGNYTCIVE-----NEYGSINHTYQL-DVVERSPHRPI 287

  Fly   298 DAQLLGSWQQAQQDGVPYYIAAELD---------YDRPEDN-RTRRFVVGDGKRYGRFTNKPLDQ 352
                       .|.|:|......|.         |..|:.: :..:.:..:|.:.|     |.:.
Human   288 -----------LQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG-----PDNL 336

  Fly   353 PDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQS-----------SVVALA 406
            |...:..:.| |:|.:...:.::.|.      .|.:|....|...|.|           .:.||.
Human   337 PYVQILKTAG-VNTTDKEMEVLHLRN------VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 394

  Fly   407 VTCVIFGSCLLLSLIAY----FYLR--------YKTCRGRRLTGGNT----HEMTLQTPIIERE- 454
            ....:..|.|.|.:|.|    |.:.        ||...|.:.:..::    |::....| :.|: 
Human   395 ERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP-LRRQV 458

  Fly   455 ----------NNGYL-----------------VEDDPLPHSPENFKQQLQQLVEGYERIPRNALR 492
                      |:|.|                 |.:..||..|.            :| :||:  |
Human   459 TVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPR------------WE-LPRD--R 508

  Fly   493 LNVNDVIGDGRFGEIITG--------------KVSTNDFARDCTLHVLCLDDLNGTTQAQLLREL 543
            |.:...:|:|.||:::..              ||:......|.|...|          :.|:.|:
Human   509 LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL----------SDLISEM 563

  Fly   544 RQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESR-------LMAPS--PRLTSLS 599
            ..:..:.:.:::::..|........|:|.|.......|:.:::|       ...||  |. ..||
Human   564 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE-EQLS 627

  Fly   600 EQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFG---PLPYMNIARQQPDHN 661
            .:.::...|::|..|.||:|.:.:||.|.:.:|.||.|..:|::.||   .:.:::..::..:..
Human   628 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 692

  Fly   662 ---RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVRPAQPA 723
               :|:|||.| ....::.:|||||...:.||...|||:||.....  ::|.:.::...|..:|:
Human   693 LPVKWMAPEAL-FDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV--EELFKLLKEGHRMDKPS 754

  Fly   724 YVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQL--MTSPRHALSFDRVAGGLDTLPPYLP 782
            ....:||.::.:||...||:|.:.:.:...:.::  :||.:..|.   ::..||...|..|
Human   755 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLD---LSMPLDQYSPSFP 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:460348
fn3 130..222 CDD:394996 9/53 (17%)
PTKc 497..750 CDD:270623 65/281 (23%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362
Ig strand A 58..61 CDD:409362
Ig strand A' 73..79 CDD:409362
Ig strand B 82..92 CDD:409362
Ig strand C 96..101 CDD:409362
Ig strand C' 104..106 CDD:409362
Ig strand D 111..115 CDD:409362
Ig strand E 118..123 CDD:409362
Ig strand F 129..138 CDD:409362
Ig strand G 141..151 CDD:409362
IgI_2_FGFR 184..278 CDD:409443 19/114 (17%)
Ig strand A 184..187 CDD:409443 0/2 (0%)
Ig strand A' 195..200 CDD:409443 0/4 (0%)
Ig strand B 204..212 CDD:409443 1/7 (14%)
Ig strand C 218..223 CDD:409443 0/4 (0%)
Ig strand C' 226..228 CDD:409443 0/1 (0%)
Ig strand D 237..240 CDD:409443 0/2 (0%)
Ig strand E 244..249 CDD:409443 0/4 (0%)
Ig strand F 258..265 CDD:409443 2/11 (18%)
Ig strand G 268..278 CDD:409443 1/10 (10%)
Ig 286..390 CDD:472250 20/126 (16%)
Ig strand B 304..308 CDD:409353 0/3 (0%)
Ig strand C 317..321 CDD:409353 0/3 (0%)
Ig strand E 355..359 CDD:409353 0/3 (0%)
Ig strand F 369..374 CDD:409353 1/4 (25%)
Ig strand G 382..385 CDD:409353 0/2 (0%)
PTKc_FGFR1 495..796 CDD:270678 75/329 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.