DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wsck and Flt3

DIOPT Version :10

Sequence 1:NP_733018.1 Gene:Wsck / 318600 FlyBaseID:FBgn0046685 Length:791 Species:Drosophila melanogaster
Sequence 2:NP_034359.2 Gene:Flt3 / 14255 MGIID:95559 Length:1000 Species:Mus musculus


Alignment Length:819 Identity:159/819 - (19%)
Similarity:280/819 - (34%) Gaps:233/819 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PIWLSSCLVAMCLGLPLGAAVPQEA---PAYYYVGCYTARTDLL------------HESVYAKTP 62
            |:|:....:.:..|..|...:..:|   .:|:.:..|:....::            :::.|    
Mouse   268 PLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGY---- 328

  Fly    63 QTCIEICEHQGHHYAVLASEKCFCANVLEPQEQQD----EQLC---------NTRC--LANKAQY 112
            .|| ...:|......|...||.| .|....||:.:    |:.|         ..||  :.::|.:
Mouse   329 YTC-SSSKHPSQSALVTILEKGF-INATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASF 391

  Fly   113 -CGGVGVHSYYSTILTK------QPGPHHLRISNKTENSLTLSWNAYEARKLLLAGGAEAVLPNQ 170
             |...|:...||  ::|      :||.:                       :..|...:|.....
Mouse   392 PCEQRGLEDGYS--ISKFCDHKNKPGEY-----------------------IFYAENDDAQFTKM 431

  Fly   171 LLDNFLIKAQVLKTYSSLPA------FPQPEF-MVQSTETQFELTDLHPATLYNISVR-----AM 223
            ...|...|.|||...|:..|      :|.|.: ..:.::.....|:..|..::|....     ..
Mouse   432 FTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQW 496

  Fly   224 CKDAQVGQSECGQA---------SIEATTE-VGLPSPVPAQPKILSRTDRTVTIELSPIRNDNGP 278
            ...:.:..||.|:.         |:..:.| :.|.||.|. |.|........||.|.        
Mouse   497 VSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPF-PFIQDNISFYATIGLC-------- 552

  Fly   279 LSKLLVIVEYVDNALSQPF--DAQLLGSWQQAQQDGVPYYI-----AAELDYDRPEDNRTRRFVV 336
            |..::|::..:.:...:.|  ::||.........|...:|:     ..:|.::.|.:|.....|:
Mouse   553 LPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVL 617

  Fly   337 GDGKRYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHDQHVTSLDDFSYATFEKGQSS 401
            |.| .:||..|                 :|..|::||                        |.|.
Mouse   618 GSG-AFGRVMN-----------------ATAYGISKT------------------------GVSI 640

  Fly   402 VVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGR-----RLTGGNTHEMTLQTPIIERENNGYLVE 461
            .||:.:......||...:|::  .|:..|..|.     .|.|.    .||..|:       ||: 
Mouse   641 QVAVKMLKEKADSCEKEALMS--ELKMMTHLGHHDNIVNLLGA----CTLSGPV-------YLI- 691

  Fly   462 DDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVL 526
                      |:......:..|.|..|........::..:..|....|.:..:|           
Mouse   692 ----------FEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSN----------- 735

  Fly   527 CLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSL--KRKLVESRLM 589
              ..:.|:.:.||...|.|||         .|.|        .||..:..:..  :::|.|..  
Mouse   736 --SSMPGSREVQLHPPLDQLS---------GFNG--------NLIHSEDEIEYENQKRLAEEE-- 779

  Fly   590 APSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIA 654
              ...|..|:.:.:|.:.|::|..|.:|.....|||.|.:.:|.||....:|:..||      :|
Mouse   780 --EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG------LA 836

  Fly   655 RQQPDHN------------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQ 707
            |.....:            :|:|||.| .:..::.:|||||...:.||..:||..||. .:..:.
Mouse   837 RDILSDSSYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYP-GIPVDA 899

  Fly   708 QLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSS 746
            ...:.|::..:..||.|....:|.::.:||..:..:|.|
Mouse   900 NFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPS 938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WsckNP_733018.1 WSC 42..115 CDD:460348 18/100 (18%)
fn3 130..222 CDD:394996 16/103 (16%)
PTKc 497..750 CDD:270623 60/264 (23%)
Flt3NP_034359.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..67
ig 256..346 CDD:395002 12/82 (15%)
Ig strand B 269..273 CDD:409353 1/3 (33%)
Ig strand C 283..287 CDD:409353 1/3 (33%)
Ig strand E 315..318 CDD:409353 0/2 (0%)
Ig strand F 328..333 CDD:409353 3/9 (33%)
7tm_GPCRs <491..>586 CDD:475119 19/103 (18%)
Protein Kinases, catalytic domain 573..950 CDD:473864 98/474 (21%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250 592..598 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1000
Blue background indicates that the domain is not in the aligned region.

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