DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34133 and DGR2

DIOPT Version :10

Sequence 1:NP_001036772.2 Gene:CG34133 / 318566 FlyBaseID:FBgn0083969 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_012801.1 Gene:DGR2 / 853738 SGDID:S000001604 Length:852 Species:Saccharomyces cerevisiae


Alignment Length:618 Identity:145/618 - (23%)
Similarity:254/618 - (41%) Gaps:168/618 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   636 FGSTMRKTVDKAKSIASEVSHARHKED--VADIVDAMNPEQNIK----IKASSSNKGPYEFTKLQ 694
            :|:.:|||:.: .|:.|...:...:.|  ..|:.|....|..::    ||.....:|..:|.::.
Yeast    81 YGTRLRKTLHR-NSVVSNGYNKLSENDRWYFDLFDRKYFENYLEEPTYIKIFKKKEGLEQFDRMF 144

  Fly   695 HVQDLSGEDT-------------------SAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAYPFF 740
            ..|:|...|.                   :::.|..||..|:.:....:|..|.:|.:.:: |. 
Yeast   145 LAQELKIPDVYKSTTYQGEPAVANSELFKNSICCCTFSHDGKYMVIGCKDGSLHLWKVINS-PV- 207

  Fly   741 QDMRNKYNADQKSSPTPSQESL--------VSQHSAEEAIAMATAAEKCTGP----------FMP 787
              .|::....:||.......||        :|.|:...:......:::..||          |..
Yeast   208 --KRSEMGRSEKSVSASRANSLKIQRHLASISSHNGSISSNDLKPSDQFEGPSKQLHLYAPVFYS 270

  Fly   788 KPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRY 852
            ..|..:..|..|:||.:||||.|::::|||||.:|||..||..|..|.|.||||:..|.|.|||:
Yeast   271 DVFRVFMEHALDILDANWSKNGFLITASMDKTAKLWHPERKYSLKTFVHPDFVTSAIFFPNDDRF 335

  Fly   853 FLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFC-QNGQFAVVGSYDGRCIFYNTDQLKY 916
            .::|.||.:.|||:|.|.:|:...:.   ..|||:.... ..|::.::|:::|......|..||:
Yeast   336 IITGCLDHRCRLWSILDNEVSYAFDC---KDLITSLTLSPPGGEYTIIGTFNGYIYVLLTHGLKF 397

  Fly   917 HTQIHV--RSTRG--KNRI-----------GRKISGIEPMPGE-DK---ILVTSNDSRVRLYDLR 962
            .:..||  :||:|  ||..           |.:|:|::....: ||   ::||:|||:::::||.
Yeast   398 VSSFHVSDKSTQGTTKNSFHPSSEYGKVQHGPRITGLQCFFSKVDKNLRLIVTTNDSKIQIFDLN 462

  Fly   963 DLNLSCKYKGYLNVSSQIKGSF--SHDGKYIIAGSENQCIYIWK--------------------- 1004
            :......:||:.:.||:.:|.|  ..:...:..||::...|.||                     
Yeast   463 EKKPLELFKGFQSGSSRHRGQFLMMKNEPVVFTGSDDHWFYTWKMQSFNLSAEMNCTAPHRKKRL 527

  Fly  1005 ------------------------------TNHDYSKLS-SVRRDRSDFWEGIK--------AHN 1030
                                          ::|.::..| :|.:.::...:.||        |||
Yeast   528 SGSMSLKGLLRIVSNKSTNDECLTETSNQSSSHTFTNSSKNVLQTQTVGSQAIKNNHYISFHAHN 592

  Fly  1031 ATVTCAIFAPHPEAIIKPEPDEISNE---------------------KLAHNQPD-PLVE----- 1068
            :.||||..|  |:..||..  .:||:                     :...|:|: |:.|     
Yeast   593 SPVTCASIA--PDVAIKNL--SLSNDLIFELTSQYFKEMGQNYSESKETCDNKPNHPVTETGGFS 653

  Fly  1069 ----QHKKGCGYVLVSADFNGAIKVFINKTKPK 1097
                ......|.:|::.|..|.|:||.....|:
Yeast   654 SNLSNVVNNVGTILITTDSQGLIRVFRTDILPE 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34133NP_001036772.2 WD40 repeat 663..700 CDD:293791 8/40 (20%)
WD40 704..1046 CDD:475233 112/460 (24%)
WD40 repeat 707..765 CDD:293791 13/65 (20%)
WD40 repeat 800..834 CDD:293791 18/33 (55%)
WD40 repeat 841..878 CDD:293791 15/36 (42%)
WD40 repeat 885..920 CDD:293791 8/35 (23%)
WD40 repeat 935..975 CDD:293791 13/43 (30%)
WD40 repeat 978..1003 CDD:293791 6/26 (23%)
WD40 repeat 1034..1069 CDD:293791 13/65 (20%)
DGR2NP_012801.1 WD40 173..506 CDD:475233 96/339 (28%)
WD40 repeat 176..238 CDD:293791 13/65 (20%)
WD40 repeat 244..278 CDD:293791 4/33 (12%)
WD40 repeat 283..317 CDD:293791 18/33 (55%)
WD40 repeat 324..360 CDD:293791 15/35 (43%)
WD40 repeat 365..414 CDD:293791 13/48 (27%)
WD40 repeat 422..476 CDD:293791 14/53 (26%)

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