DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34133 and AT2G37670

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001323654.1	Gene:	AT2G37670 / 818344	AraportID:	AT2G37670	Length:	904	Species:	Arabidopsis thaliana

Alignment Length:	833	Identity:	215/833 - (25%)
Similarity:	365/833 - (43%)	Gaps:	155/833 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 ISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFESSLNNATSSASNITLTCSSTNT 365
            :||:..:.:..|.:.|.|.|.              ||..:.|.|::::.|:::........|.:.
plant    39 LSSALTFDMANASSSDEDEDF--------------DDCRLSFSSAVSSLTTASRKFRTPAMSPDY 89

  Fly   366 VVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSSTSVHSKPSPSNSAKSNSAPA 430
            .:..:|         |.:|:...|.::..:.:|..|...|..|....|.:.|..||..:......
plant    90 DIWMAA---------PGSISERRRRLLHGMGLASNKDMVSAVSIRRVVSNAPVVSNGEEKKMKKK 145

  Fly   431 RVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDEIER--IEKM----LMESANRPKLAG 489
            ....:|.....::...:               |:..|:.:|||  |||.    ::...::.:|..
plant   146 MNHEVDEQDHDHVPVML---------------ARSRSESDIERFLIEKRRKEEILGKISKQRLTR 195

  Fly   490 TGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVP---- 550
            |.|....:.||...:...:  ::.....|:...|:          ..|:.||......:|.
plant   196 TYSTICPTRTRICQYQTPI--RQTPAVCGNGKALR----------GGGEALTSVMSNARVGAFFL 248

  Fly   551 VKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPPSIEGQQPDEE 615
            :||||||:...::|.....:   ||.||    .|.:..::..:|.  |..:|..|.:      :|
plant   249 IKNLDTGKEFIVNEYDEDGM---WNRLS----DLQTGKQLTLEEF--EKCVGYSPVV------KE 298

  Fly   616 ELETEDGSRLK--------------KKTARIKRFFGSTMRKTVDKAKSIASEVSHARHKEDVAD- 665
            .:..|:.:|:.              .|:.|:.:..|:.:.|.:   |.:|..:|.....:||:|
plant   299 LMRRENVNRINYEPLMDLRKFNSYLSKSVRLSKRRGAALLKNI---KGVAHSMSLRVADKDVSDG 360

  Fly   666 -------IVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAG 723
                   ..|..:.:.|..:|...:.|...|.:.|...|::...: .|||.:|||.....||:.|
plant   361 STDSPKKGKDHKHGKANEWVKVRPTGKSYKELSALHMCQEIQAHE-GAVWTIKFSQDAHYLASGG 424

  Fly   724 QDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATAAEKCTG----- 783
            .|:|:.:|.:::.         :..:..:.|.||...||..  |:...|.:....:|..|
plant   425 ADRVIHVWEVQEC---------ELMSMNEGSLTPIHPSLCD--SSGNEITVVEKKKKGKGSSGRR 478

  Fly   784 ---------------PFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCC 833
                           .|..||.|:..||...:||:||||:..:||||||||||||.|..|.||..
plant   479 HNHIPDYVHVPETVFSFSDKPVCSLKGHLDAILDLSWSKSQLLLSSSMDKTVRLWDIETKTCLKL 543

  Fly   834 FQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAV 898
            |.|.|:||.|.|.|.|:.||||||||.|:|:|:|.|:.|..|:::.   :::|||.:..:||.|:
plant   544 FAHNDYVTCIQFSPVDENYFLSGSLDAKIRIWSIQDRHVVEWSDLH---EMVTAACYTPDGQGAL 605

  Fly   899 VGSYDGRCIFYNTD--QLKYHTQIHVRSTRGKNRIGRKISGIEPMP-GEDKILVTSNDSRVRLYD 960
            :||:.|.|..|:|:  :|....||.|:|.: |::..|||:..:..| ...::||||.|||:|:.|
plant   606 IGSHKGICRAYDTEDCKLSQTNQIDVQSNK-KSQAKRKITSFQFSPVNPSEVLVTSADSRIRILD 669

  Fly   961 LRDLNLSCKYKGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEG 1025
              ...:..|:||:.|..||:..|:|.||||||..||:..:|:||.:...::.:...:....|
plant   670 --GSEVIHKFKGFRNTCSQLSASYSQDGKYIICASEDSQVYLWKNDFHRTRSTLTTQSHEHF--- 729

  Fly  1026 IKAHNATVTCAIFAP-HPEAIIKPEPDEISNEK-----LAHNQPDPLVEQHKK 1072
               |...|:.|:  | |.....:|.|.:|.:::     ...:||...:....|
plant   730 ---HCKDVSAAV--PWHGHVRGEPPPVQIHSKRHSKRISTSSQPSSTISSPTK 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	9/44 (20%)
		WD40	704..1101	CDD:225201	135/398 (34%)
		WD40	704..1046	CDD:295369	129/365 (35%)
		WD40 repeat	707..765	CDD:293791	16/57 (28%)
		WD40 repeat	800..834	CDD:293791	22/33 (67%)
		WD40 repeat	841..878	CDD:293791	20/36 (56%)
		WD40 repeat	885..920	CDD:293791	13/36 (36%)
		WD40 repeat	935..975	CDD:293791	14/40 (35%)
		WD40 repeat	978..1003	CDD:293791	13/24 (54%)
		WD40 repeat	1034..1069	CDD:293791	8/40 (20%)
AT2G37670	NP_001323654.1	WD40	399..711	CDD:421866	122/329 (37%)
		WD40 repeat	409..449	CDD:293791	11/48 (23%)
		WD40 repeat	454..544	CDD:293791	33/91 (36%)
		WD40 repeat	551..587	CDD:293791	20/35 (57%)
		WD40 repeat	592..629	CDD:293791	13/36 (36%)
		WD40 repeat	643..678	CDD:293791	12/36 (33%)
		WD40 repeat	684..710	CDD:293791	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I1203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970