Protein Alignment CG34133 and Wdr44

DIOPT Version :10

• Sequence 1: NP_001036772.2
• Gene: CG34133 / 318566
• FlyBaseID: FBgn0083969
• Length: 1108
• Species: Drosophila melanogaster
• Sequence 2: XP_038955377.1
• Gene: Wdr44 / 246152
• RGDID: 727965
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 1173
• Identity: 443/1173 - (37%)
• Similarity: 577/1173 - (49%)
• Gaps: 338/1173 - (28%)

  Fly     4 LETDSDSSEEFFDAEDTTPNRHSTLCRKLPPEVAQEFIFPEPAVRVNAAASSDSDATPIGAGTPA 68
            :.::|| :|||:||                         ||.   |:...|     .|:|:
  Rat     1 MASESD-TEEFYDA-------------------------PED---VHLGGS-----YPVGS---- 27

  Fly    69 TRSPTNSLGARLKPQDAGV--FVEPKPVIGPLGRQR-FHELRQCMQND------EDDNPGNTLTP 124
                         |...|:  |.|.|......|.:. ..||||.:...      |:......|..
  Rat    28 -------------PGKVGLLSFKETKNTGNKAGNESPVQELRQDVSKKIIECIIEESQKVLQLED 79

  Fly   125 DSQNSSTDGIFTNRSTHPFKVIETDAMSIQSMTSLGRVGRILAGSIDPSAISIDRESLASLNAQQ 189
            ||.:|...|: ::::|....|..|:..:|                  |..::|..|      .||
  Rat    80 DSLDSKGKGL-SDQATASHSVAGTEFSNI------------------PGLLAIQHE------LQQ 119

  Fly   190 QKQQAQQQQQAQPTSSTSSNTPPSVGNTSSGMST-------PRVSPKHQQS---------GKEVA 238
            ..::|..|..|:.|...:....||..|......|       ..||...|..         .||..
  Rat   120 GSRKADSQNAAEETELETQKCFPSDNNCEKSEKTEDETNNLTEVSSADQLDASKLETEILNKEAV 184

  Fly   239 ATTTG--IPSAASSAQSSGVGSMVLQ------------EPDVIASTKLAQSKTTDSITSSGP--- 286
            ....|  :..|:|.|.|:...:.|.:            |||::||||..........|:..|
  Rat   185 EVKEGDVVNPASSDALSTKDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRP 249

  Fly   287 -----VAPPRRKKKSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFES-S 345
                 .|||.|||||.                                          :|||: .
  Rat   250 PPPSRPAPPPRKKKSD------------------------------------------LEFEALK 272

  Fly   346 LNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSS 410
            ..:......||                   ||.||                     ||.::.|.|
  Rat   273 TPDLDVPKDNI-------------------ASDSL---------------------LTTNMASES 297

  Fly   411 TSVHSKPSPSNSAKSNSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDEIERIE 475
            |...|.||                      |:|..|..|..:|..:
  Rat   298 TVRDSLPS----------------------LDLASATSGDKIVTAQ------------------- 321

  Fly   476 KMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQL 540
                |:...|.:.......:|..                                |.|::||::|
  Rat   322 ----ENGKAPDVQTVAGEVMGPQ--------------------------------RPRSNSGREL 350

  Fly   541 TDFEILEQVPVKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPP 605
            ||.|||..|.:|||||||.:||| :....:|.|.|||:|||::.|.  |.::.|...::.
  Rat   351 TDEEILASVMIKNLDTGEEIPLS-LAEEKLPTGINPLTLHIMRRTK--EYVRYELSNDAT----- 407

  Fly   606 SIEGQQPDEEELETE----DGSRLKKKTARIKRFFGSTMR-----------KTVDKAKSIASEVS 655
                |..|||:|:::    ||.|||:||.::|:|.|.:::           :.::|.||:..||.
  Rat   408 ----QSDDEEKLQSQQTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSVRDEVF 468

  Fly   656 HARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLA 720
            |....:..:...:.|...:.:|.||:...||||:|.:::.|||||||...|||.||||.||||||
  Rat   469 HTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLA 533

  Fly   721 TAGQDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATAAEKCTG-- 783
            :||||.::|||.||:|:.:|.:||.|||.:.:.||:||||||.|..|       .|....|:|
  Rat   534 SAGQDNIVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKS-------DTDMGVCSGTD 591

  Fly   784 --------PFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFV 840
                    ||..:|||.|.|||:||||:|||||||:||||||||||||||||:||||||||||||
  Rat   592 EDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFV 656

  Fly   841 TAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGR 905
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||::||:|:||||
  Rat   657 TAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGR 721

  Fly   906 CIFYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKY 970
            ||||:|:.||||||||||||||:|::||||:||||:|||:||||||||||:||||||||:||.||
  Rat   722 CIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKY 786

  Fly   971 KGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTC 1035
            |||:|.|||||.|||||..|:::|||::.:|||.|.||.||.:||||||:|||||||||||.||.
  Rat   787 KGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTS 851

  Fly  1036 AIFAPHPEAIIKPEP--------DEISNEKLAHNQPDPLVEQHKKGCGYVLVSADFNGAIKVFIN 1092
            |||||:|..::..:.        |:..:.::..|....:|   |.....||:||||.||||||||
  Rat   852 AIFAPNPSLMLSLDVQSEKLEGIDKYEDAEVLDNTSTGIV---KTDNTEVLLSADFTGAIKVFIN 913

  Fly  1093 KTK 1095
            |.|
  Rat   914 KRK 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1046	CDD:475233	255/351 (73%)
		WD40 repeat	707..765	CDD:293791	36/57 (63%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	33/39 (85%)
		WD40 repeat	978..1003	CDD:293791	14/24 (58%)
		WD40 repeat	1034..1069	CDD:293791	10/42 (24%)
Wdr44	XP_038955377.1	WD40	516..863	CDD:475233	255/353 (72%)
		WD40 repeat	520..611	CDD:293791	47/97 (48%)
		WD40 repeat	617..651	CDD:293791	30/33 (91%)
		WD40 repeat	656..692	CDD:293791	35/35 (100%)
		WD40 repeat	702..735	CDD:293791	25/32 (78%)
		WD40 repeat	751..787	CDD:293791	29/35 (83%)