Protein Alignment CG34133 and sym-4

DIOPT Version :10

• Sequence 1: NP_001036772.2
• Gene: CG34133 / 318566
• FlyBaseID: FBgn0083969
• Length: 1108
• Species: Drosophila melanogaster
• Sequence 2: NP_510361.1
• Gene: sym-4 / 181527
• WormBaseID: WBGene00006369
• Length: 1043
• Species: Caenorhabditis elegans
• Alignment Length: 1075
• Identity: 344/1075 - (32%)
• Similarity: 518/1075 - (48%)
• Gaps: 237/1075 - (22%)

  Fly   179 RESLASLNAQQQKQQAQQQQQAQPTSST--SSNTPPSVGNTSSGMSTPRVSPKHQQSGKEVAATT 241
            |..:.:..|....:.|.::.:...||||  ||::.|    .|:..:||.:|             :
 Worm    43 RPEVLNFAAPSATRLAMRRSEQPVTSSTPFSSSSRP----MSAVFNTPSLS-------------S 90

  Fly   242 TGIPSAASSA----------------QSSGVGSMVLQEPDVIASTKLAQSKTTDSITSSGPVAPP 290
            :|.|:.::|:                .:...|:..|..|  .|.|.....:|..:::.:..:...
 Worm    91 SGFPATSTSSIRDSSHRDRLISLRHRMNKEFGNRQLVGP--TAQTDYEHDETMSTVSDAPSLHSW 153

  Fly   291 RRKK--KSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFESSLNNATSSA 353
            ..|.  |:....::::|..|...|...:                       |.||:||.:.::::
 Worm   154 HHKMIVKNETVIVNATDTLSSCAAPRSE-----------------------MGFENSLISQSNTS 195

  Fly   354 SNITLT-------------CSSTNTVVSASASTSAASSSLPSTIAIH------------------ 387
            :|.|:|             .|||.|...:|.|..:.|:.:|..|...
 Worm   196 ANATITPMKVNIPIDESRHRSSTWTPTDSSCSGISPSTRVPPPIPSRAPVMSPVQSPLTHPPVAP 260

  Fly   388 -------MRPMVASVTIAGP---------------KLTQ---SLGSSSTSVHSKPSPSNSAKSNS 427
                   :.|...|:.:..|               .|.|   |:|||.:|.....|.:...|..:
 Worm   261 MPRCPPPLPPRTPSMKLPDPIAFEVENRIEEERKKNLIQREISVGSSKSSDALMASTTPDVKEVN 325

  Fly   428 APARVSSIDPNQGLNLFKAIQ-----------GGYVVKPRDEASNKA-------------QGPSQ 468
            ...:.:|||  :||.:.||::           ||......:|..|..             ...:.
 Worm   326 GHRKSNSID--RGLTIAKAMKTGPFPPNALALGGREATGEEEERNVVAEEVIRQITTDVETAHNL 388

  Fly   469 DEIERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYV--- 530
            .:.:.::.|.:|:      ..:.|||..||                .|:..|...||:.|.:
 Worm   389 SDCQNVDTMSLET------IPSASNSTASS----------------PSSASEAECKQIAIRIPDP 431

  Fly   531 --RTRTSSGKQLTDFEILEQV----PVKNLDTGENMPLS--EMR---SPPVPEGWNPLSLHILKL 584
              ....||.|   .|..||.|    |.|.:....:..||  |:|   |..:....:|::|.:.:.
 Worm   432 IPEEAPSSSK---SFGALESVNSLSPAKTVTNRNSRSLSNDELRTNKSDKLSSSVDPITLDVERR 493

  Fly   585 TSHLEVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRLKKKTARIKRFFGSTMRKTVDKAKS 649
            .|.....|.|||..|:..:..:...:......:|:  .:...:.:.|    :.|.|.:...|...
 Worm   494 LSMKRSGQHESDRHSIGSLDETTSNRTLSRTGIES--AASFARNSVR----YASGMLRGAFKRVR 552

  Fly   650 IASEVSHA---RH--KEDVADIVDAMNPE------QNIKIKASSSNKGPYEFTKLQHVQDLSGED 703
            ||:....:   ||  .|:.:|..::..|.      .|| ::...|.||||:|..|...|:|:.|.
 Worm   553 IAAHPGSSSLNRHGIGEETSDGEESDEPHHPSVAPSNI-VRPRKSKKGPYDFEHLTVEQELNNEH 616

  Fly   704 TSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAYPFFQDMRNKY--NADQKSSPTPSQESLVSQH 766
            |.|:||:|||.||:|:||||||.:||:||::....:|.|||.||  ||:.::.|..|.:::  :|
 Worm   617 TGAIWCIKFSICGKLMATAGQDSILRVWVVRSHLQYFSDMREKYAANANPEADPMNSVDNM--EH 679

  Fly   767 ----SAEEAIA---MATAAEKCTGPFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWH 824
                |:.|::.   ..||::...|.|..|||....|||:|:||||||||||||||.||:||:|||
 Worm   680 FRPPSSMESVVNSEATTASDDNNGLFCAKPFALLKGHTADILDVSWSKNYFILSSGMDRTVKLWH 744

  Fly   825 ISRKECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAAN 889
            :||.|||||||||||||.:||.|:|||||||||||||||:|:|||||||:||  |.:.|.|||..
 Worm   745 LSRNECLCCFQHIDFVTCVAFLPKDDRYFLSGSLDGKLRMWHIPDKKVAVWN--DTEKKYITAMT 807

  Fly   890 FCQNGQFAVVGSYDGRCIFYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDS 954
            |.::|:|||||:|||:||||.:|||||||.:.||||||||..|.|::|:  ....||:|||||||
 Worm   808 FVKSGKFAVVGTYDGKCIFYTSDQLKYHTAVDVRSTRGKNARGHKVTGL--TSHGDKLLVTSNDS 870

  Fly   955 RVRLYDLRDLNLSCKYKGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDR 1019
            |:|:||:||..|:||:||..|..|||:.:||.||::||.|||::.:|||:.: |.:...|||:||
 Worm   871 RIRMYDIRDKALTCKFKGVQNDHSQIRAAFSPDGRHIICGSEDKFVYIWRAS-DTTVALSVRKDR 934

  Fly  1020 SDFWEGIKAHNATVTCAIFAPHPEAIIK--------PEPDEIS---NEKLAHNQPDPLVEQHKKG 1073
            :.:||.::.|||.|..|:|||.|:....        .:.|.|.   :.::...|.|.|.......
 Worm   935 NSWWERVRTHNAPVPVAVFAPRPQVFFNMLNKRDKHSKSDSIDFNISGQVLPGQSDSLTSNGNLS 999

  Fly  1074 C-GYVLVSADFNGAIKVFINKTK--------PKHS 1099
            . |:|::|||.||.|||.||:.:        ||:|
 Worm  1000 IPGHVIISADLNGVIKVMINRPRLVKANPLDPKNS 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/42 (29%)
		WD40	704..1046	CDD:475233	198/350 (57%)
		WD40 repeat	707..765	CDD:293791	28/59 (47%)
		WD40 repeat	800..834	CDD:293791	27/33 (82%)
		WD40 repeat	841..878	CDD:293791	29/36 (81%)
		WD40 repeat	885..920	CDD:293791	24/34 (71%)
		WD40 repeat	935..975	CDD:293791	21/39 (54%)
		WD40 repeat	978..1003	CDD:293791	13/24 (54%)
		WD40 repeat	1034..1069	CDD:293791	10/45 (22%)
sym-4	NP_510361.1	WD40	<616..923	CDD:441893	181/313 (58%)
		WD40 repeat	620..654	CDD:293791	18/33 (55%)
		WD40 repeat	721..755	CDD:293791	28/33 (85%)
		WD40 repeat	760..796	CDD:293791	28/35 (80%)
		WD40 repeat	804..843	CDD:293791	25/38 (66%)
		WD40 repeat	850..887	CDD:293791	21/38 (55%)